Semen quality and sperm DNA methylation in relation to long-term exposure to air pollution in fertile men: A cross-sectional study

Cheng, Yu‐Ting; Tang, Qiuqin; Lu, Yiwen; Li, Mei; Zhou, Yijie; Wu, Peihao; Li, Jinhui; Pan, Feng; Han, X. D.; Chen, Minjian; Lu, Chuncheng; Wang, Xinru; Xia, Yankai

doi:10.1016/j.envpol.2022.118994

Cited by 24 publications

(2 citation statements)

References 62 publications

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“…Male infertility can be related to the deviation in the DNA methylation level of sperm. A negative correlation has been reported between the DNA methylation level and sperm motility or morphology (Cheng et al, 2022;Narud et al, 2021)…”

Section: Discussionmentioning

confidence: 99%

Effects of different extenders on epigenetic patterns and functional parameters of bull sperm during cryopreservation process

Fouladvandi,

Masoudi,

Totonchi

et al. 2024

Reprod Domestic Animals

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The cryopreservation process induces alterations in cellular parameters and epigenetic patterns in bull sperm, which can be prevented by adding cryoprotectants in the freezing extenders. The purpose of this study was to compare the protective effects of two extenders based on soybean lecithin (SLE) and egg yolk (EYE) on epigenetic patterns and quality parameters of sperm such as motility parameters, mitochondrial membrane integrity, DNA fragmentation, viability, and apoptotic‐like changes of bull sperm after cryopreservation. Results demonstrated that cryopreservation significantly (p < .05) reduced the level of DNA global methylation, H3K9 histone acetylation, and H3K4 histone methylation in both frozen groups compared to the fresh sperm. Also, the level of H3K9 acetylation was lower in the frozen SLE group (21.2 ± 1.86) compared to EYE group (15.2 ± 1.86). In addition, the SLE frozen group had a higher percentage of viability, progressive motility, and linearity (LIN) in SLE frozen group compared to EYE frozen group. However, no difference was observed in mitochondrial membrane integrity and DNA fragmentation between SLE and EYE frozen groups. While soybean‐lecithin‐based extender showed some initial positive impacts of epigenetics and semen parameters, further investigations can provide useful information for better freezing.

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Section: Discussionmentioning

confidence: 99%

Effects of different extenders on epigenetic patterns and functional parameters of bull sperm during cryopreservation process

Fouladvandi,

Masoudi,

Totonchi

et al. 2024

Reprod Domestic Animals

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show abstract

“…In addition, it was found that co-exposure to six air pollutants was related to a decrease in sperm motility and, therefore, to a poor chance of large offspring. In particular, exposure to PM 10 led to a decrease in sperm DNA methylation [ 92 ].…”

Section: Link Between Toxicants Exposure Dna Methylation and Biologic...mentioning

confidence: 99%

Evolutionary Implications of Environmental Toxicant Exposure

et al. 2022

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Homo sapiens have been exposed to various toxins and harmful compounds that change according to various phases of human evolution. Population genetics studies showed that such exposures lead to adaptive genetic changes; while observing present exposures to different toxicants, the first molecular mechanism that confers plasticity is epigenetic remodeling and, in particular, DNA methylation variation, a molecular mechanism proposed for medium-term adaptation. A large amount of scientific literature from clinical and medical studies revealed the high impact of such exposure on human biology; thus, in this review, we examine and infer the impact that different environmental toxicants may have in shaping human evolution. We first describe how environmental toxicants shape natural human variation in terms of genetic and epigenetic diversity, and then we describe how DNA methylation may influence mutation rate and, thus, genetic variability. We describe the impact of these substances on biological fitness in terms of reproduction and survival, and in conclusion, we focus on their effect on brain evolution and physiology.

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Epigenetic Alterations in Male Infertility

Navarro-Gomezlechon,

Garrido

2024

Current and Future Advances in Male Infertility

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Semen quality and sperm DNA methylation in relation to long-term exposure to air pollution in fertile men: A cross-sectional study

Cited by 24 publications

References 62 publications

Effects of different extenders on epigenetic patterns and functional parameters of bull sperm during cryopreservation process

Effects of different extenders on epigenetic patterns and functional parameters of bull sperm during cryopreservation process

Evolutionary Implications of Environmental Toxicant Exposure

Epigenetic Alterations in Male Infertility

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