Semen Quality Decline Among Men in Infertile Relationships: Experience Over 12 Years in the South of Tunisia

Feki, Nozha Chakroun; Abid, Nouha; Rebai, Ahmed; Sellami, Afifa; Ayed, B. Ben; Guermazi, M.; Bahloul, A.; Rebaï, Tarek; Ammar, L. Keskes

doi:10.2164/jandrol.108.005959

Cited by 65 publications

(45 citation statements)

References 39 publications

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“…35 Nevertheless, our results appear to be in keeping with the hypothesis advanced by Sharpe and Skakkebaek;36 that is, environmental factors during foetal, childhood/pubertal period or adult life, can have detrimental effects on spermatogenesis. The higher risk of testicular cancer and poor semen quality over the past decades has drawn attention to the possibility that environmental xenoestrogens may be implicated.…”

Section: Contribution Of Environmental Factorssupporting

confidence: 89%

Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

Geoffroy-Siraudin¹,

Loundou²,

Romain³

et al. 2012

Asian J Androl

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Semen from 10 932 male partners of infertile couples was analysed and sperm parameter trends were evaluated at the Reproduction Biology Laboratory of the University Hospital of Marseille (France) between 1988 and 2007. After 3-6 days of abstinence, semen samples were collected. Measurements of seminal fluid volume, pH, sperm concentration, total sperm count, motility and detailed morphology of spermatozoa were performed. Sperm parameters were analysed on the entire population and in men with normal total numeration (o40 million per ejaculate). The whole population demonstrated declining trends in sperm concentration (1.5% per year), total sperm count (1.6% per year), total motility (0.4% per year), rapid motility (5.5% per year) and normal morphology (2.2% per year). In the group of selected samples with total normal sperm count, the same trends of sperm quality deterioration with time were observed. Our results clearly indicate that the quality of semen decreased in this population over the study period. Keywords: environment; male infertility; regional differences; semen quality; sperm parameters INTRODUCTION Numerous studies suggest a decline in semen quality in some parts of the world. 1-8 By contrast, other studies have shown no evidence of deteriorating semen quality. 9-16 Some studies concern infertile couples, while others analyse normal sperm parameters. Thus, a worldwide decreasing trend in semen parameter values can be neither confirmed nor rejected. 17 It was recently reported that fecundity is affected by this decrease. 18,19 It was speculated that decreasing sperm parameters are in response to adverse environmental factors. Nevertheless, the observed discrepancies between studies suggest regional differences in semen quality. [20][21][22] Variations in environmental factors, industrial pollution and/or lifestyle could explain these discrepancies. A large number of environmental factors can pollute air, drinking water and food. This can directly alter the male gonad by blood-testis barrier disruption and cellular toxicity, or disrupt androgen biosynthesis and action. Among these environmental factors, oestrogenic or anti-androgenic endocrine disrupting compounds inhibit critical cellular process controlling steroidogenesis in Leydig cells and androgen binding to the androgen receptor. 23 It has been hypothesized that endocrine disrupting compounds play a major role in the aetiology of increased incidence of testicular dysgenesis syndrome which gathers decreased quality of semen, cryptorchidism, hypospadias and testicular cancer. 24 Chemicals with hormone-like activity can also

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Section: Contribution Of Environmental Factorssupporting

confidence: 89%

Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

Geoffroy-Siraudin¹,

Loundou²,

Romain³

et al. 2012

Asian J Androl

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“…The effects of age on fertility are real and may be greater than has been thought and it's well known that the fertility declines with age [22]. Previous studies documented that age is associated with diminished in semen volume, sperm count, sperm concentration, motility and morphology [38,39]. Similarly, we concluded that increasing age is associated with decreased seminogram and older men have lower semen volume and sperm parameters.…”

Section: C-a Comparison Of Semen Parameters and Mda Among Infertile Msupporting

confidence: 54%

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

AL-Naqshbandi¹,

AL-Barzinji²

2017

Cihan Univ.-Erbil Sci. J.

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Male infertility is an important medical and psychosocial problem worldwide. Therefore, it is important to identify new and non-conventional factors that may play significant role in male infertility. Current study focused on detecting more risk factors and markers for primary infertility in order to develop interventions for investigation and prevent their progressions. Oxidative stress has recently been identified as an underlying mechanism of numerous sources. The aim of the present study was therefore to evaluate whether there is an association between oxidative stress and male infertility in Erbil city subjects. The present prospective case control study was carried out between March to May 2013, in Maternity Teaching Hospital/in-vitro fertilization center and private clinical laboratory. 75 infertile males represent patients group were enrolled in this study. Apparently 40 healthy individuals who have no history of clinical evidence of any disease were also joined to this study as control group. Malondialdehyde (MDA), the marker of lipid peroxidation was measured in the seminal fluid of fertile and infertile male subjects. The sperm count, sperm morphology and motility, as well as semen volume were all found significantly lower in infertile subjects compared with fertile subjects (p<0.01). In seminal plasma, the MDA level was found significantly higher in infertile group (p<0.05). Lifestyle behaviours such as varicocele repair, cigarette smoking and alcohol consumption, all enhance the generation of ROS level in the seminal plasma, such elevation associated with decreased sperm quality particularly in term of sperm count and sperm motility that leading to increase male infertility.

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“…Research articles on humans published in English from 1965 to 2015 were included in this report [23][24][25][26][27][28][29][30][31][32][33][34][35][36] (Table 1). .…”

Section: Data Extraction and Data Anaysismentioning

confidence: 99%

Evidence for decreasing sperm count in African population from 1965 to 2015

Sengupta¹,

Nwagha²,

Dutta³

et al. 2017

Afr H. Sci.

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Purpose: This meta-analysis, following our previous reports those documented an overall 57% diminution in mean sperm concentration around the globe over past 35 years and 32.5% decline in past 50 years in European population, attempts to report the declining trend of sperm concentrations in African population between 1965 and 2015. Methods: In the course of retrieval of data following MOOSE guidelines and PRISMA checklist, we found a total of fourteen studies that have been conducted during that period on altering sperm concentration in the African male. Results: Following analysis of the data, a time-dependent decline of sperm concentration (r = -0.597, p = 0.02) and an overall 72.6% decrease in mean sperm concentration was noted in the past 50 years. The major matter of concern is the present mean concentration (20.38×10 6 /ml) is very near to WHO cut-off value of 2010 of 15×10 6 /ml. Several epidemic diseases, genital tract infection, pesticides and heavy metal toxicity, regular consumption of tobacco and alcohol are reported as predominant causative factors. Conclusion: This comprehensive, evidence-based meta-analysis and systematic review concisely presents the evidence of decreased sperm concentration in the African male over past 50 years with possible causative factors to serve the scientific research zone related to male reproductive health.

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Semen Quality Decline Among Men in Infertile Relationships: Experience Over 12 Years in the South of Tunisia

Cited by 65 publications

References 39 publications

Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

Evidence for decreasing sperm count in African population from 1965 to 2015

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