Semen quality of 1559 young men from four cities in Japan: a cross-sectional population-based study

Iwamoto, Teruaki; Nozawa, Shiari; Mieno, Makiko; Yamakawa, Katsunori; Baba, Katsuyuki; Yoshiike, Miki; Namiki, Mikio; Koh, Eitetsu; Kanaya, Jiro; Okuyama, Äkïhïko; Matsumiya, Kiyomi; Tsujimura, Akira; Kanetake, Hiroshi; Eguchi, Jiro; Skakkebæk, Niels E.; Vierula, Matti; Toppari, Jorma; Jørgensen, Niels

doi:10.1136/bmjopen-2012-002222

Cited by 47 publications

(60 citation statements)

References 36 publications

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“…A meta-analysis by Carlsen et al [4] suggested that there has been a general decline in sperm concentration and total sperm count over a period of 50 years. In addition, a recent cross-sectional study of men from Danish and Japanese populations showed that the semen analysis results for young men from the general population were lower than for those men identified as being fertile [5][6][7]. However, the reason for this is unclear.…”

Section: Introductionmentioning

confidence: 88%

Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men1

Sato

Iwamoto

Shinka

et al. 2014

Biology of Reproduction

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Several case-control studies have investigated whether Y chromosome haplogroups or deletions are associated with spermatogenic failure. However, the relationships between Y chromosome haplogroups or deletions and semen quality in general population have not been elucidated. In this study, we assessed relationships between Y chromosome haplogroups or deletions and semen parameters in 791 fertile Japanese men and 1221 young men from the general Japanese population. We found that the haplogroup D2 (M55 lineage) was significantly associated with lower semen parameters, especially total motile sperm count (P = 0.00051, beta = -0.097), in men from the general population but not in fertile men. In addition, we found that the gr/gr subdeletion was associated with semen quality and in particular, strongly associated with decreased sperm motility (P = 0.00041, beta = -3.14) and total motile sperm count (P = 0.00031, beta = -0.099) in men from the general population but not in fertile men. The combined analysis of fertile Japanese men and men from the general Japanese population showed that the haplogroup D2 (M55 lineage) and the gr/gr subdeletion were strongly associated with reduced sperm motility (P = 0.00056, beta = -2.71, and P = 7.7 × 10(-5), beta = -3.05, respectively) and that haplogroup O2b1 was strongly associated with elevated sperm motility (P = 0.00089, beta = 2.94). These observations add further support for the view that the gr/gr subdeletion diminishes sperm motility that consequently may result in male infertility.

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Section: Introductionmentioning

confidence: 88%

Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men1

Sato

Iwamoto

Shinka

et al. 2014

Biology of Reproduction

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“…A few of the subjects in this study have been described in previous reports (Iwamoto et al, 2013a,b;Sato et al, 2014). Briefly, samples in cohort 1 were recruited from university students in three study centers based in the urology departments at university hospitals in Japan (Kawasaki, Kanazawa and Nagasaki), as previously reported (Iwamoto et al, 2013b). In addition, we recruited participants from university students at a study center in Sapporo, as previously reported (Sato et al, 2014).…”

Section: Two Japanese Cohort Samples and Y Chromosome Haplogroupingmentioning

confidence: 99%

Y chromosome haplogroup D2a1 is significantly associated with high levels of luteinizing hormone in Japanese men

et al. 2015

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SUMMARYThe association between the Y chromosome haplogroup D2 and risk of azoospermia and low sperm motility has been previously studied, and it was indicated that haplogroups DE (YAP lineage) are associated with prostate cancer risk in Japanese males. Our assumption had been that Y chromosome haplogroups may be associated with sex hormone levels, because sex hormones have been deemed responsible for spermatogenesis and carcinogenesis. In this study, we assessed the association between Y chromosome haplogroups and sex hormone levels, including those of testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), inhibin-B, and calculated free testosterone (cFT), in 901 young men from the general Japanese population (cohort 1) and 786 Japanese men of proven fertility (cohort 2). We found that the haplogroup D2a1 was significantly associated with high LH levels in a combined analysis involving two cohorts (b = 0.068, SE = 0.025, p = 0.0075), following correction for multiple testing. To date, this result is the first evidence that implicates Y chromosome haplogroups in an association with sex hormone levels.

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“…However, the most common cause of male infertility is due to sperm production abnormalities such as a low sperm count and/or poor sperm quality [2]. Interestingly, in a recent cross-sectional population study Iwamoto et al [3] reported that semen quality of young Japanese people is lower than that of a reference population of fertile men.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hachimijiogan, a Kampo powder, on epididymidis sperm characteristics in healthy male rats

Wang

Murayama²,

Michihara³

et al. 2014

Reprod Medicine & Biology

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Purpose Hachimijiogan (HJG, Rehmannia Eight Formula), a kidney-replenishing Kampo formula, is clinically known to be effective in the treatment of male infertility with oligozoospermia. The purpose of this study was to evaluate the effect of HJG on the epididymal sperm characteristics and related serum hormone changes in rats in an attempt to determine its mechanism. Methods Male Wistar-Imamichi rats (233.4 ± 5.2 g, nine weeks old) were assigned randomly to four groups (n = 6 for each group). Apart from one control group treated with distilled water, the other groups were administered HJG consecutively for 9-11 days with doses of 250, 500 and 1,000 mg/kg. After the last administration the caude epididymides were quickly removed under anesthesia for assessing sperm characteristics. Additionally, the testes, seminal vesicles, prostate and adrenal glands were removed surgically and their wet weights measured. Results Results showed that HJG increased sperm numbers and motility as well as the weights of seminal vesicles and adrenal glands at lower doses. Moreover, HJG decreased serum levels of testosterone and luteinizing hormone while increasing follicle-stimulating hormone levels. Conclusions Our findings may support the conclusion that a lower dosage of HJG has an effect on improving local spermatogenous environments by activating adrenal functions and/or promoting local androgen activity.

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Semen quality of 1559 young men from four cities in Japan: a cross-sectional population-based study

Cited by 47 publications

References 36 publications

Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men1

Y Chromosome gr/gr Subdeletion Is Associated with Lower Semen Quality in Young Men from the General Japanese Population but Not in Fertile Japanese Men1

Y chromosome haplogroup D2a1 is significantly associated with high levels of luteinizing hormone in Japanese men

Effects of Hachimijiogan, a Kampo powder, on epididymidis sperm characteristics in healthy male rats

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