Semen quality of workers occupationally exposed to hydrocarbons

Célis, Ruth De; Feria‐Velasco, Alfredo; González-Unzaga, Marco; Torres-Calleja, Jorge; Pedrón-Nuevo, Nives

doi:10.1016/s0015-0282(99)00515-4

Cited by 80 publications

(18 citation statements)

References 24 publications

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“…These data confirm the toxic effect of benzene on spermatogenesis, as previously described (De Celis et al, 2000). Moreover, the findings show a high negative correlation between seminal tt-MA levels and the principal semen parameters.…”

Section: Discussionsupporting

confidence: 91%

“…Benzene is a male germ cell clastogen: cytogenetic damage to the differentiating spermatogonia of Swiss CD1 mice was induced 24 h after a single oral treatment of benzene at 880 mg kg-' (Ciranni et al, 1991). Finally, impairment of spermatogenesis resulting from hydrocarbon exposure (ethylbenzene, benzene, toluene and xylene) has been recently demonstrated in men by an increased rate of spermatozoa with abnormal morphology in the semen of exposed workers compared with unexposed ones (De Celis et al, 2000). This difference may be attributed to a lower concentration of active metabolites in the spermatogonia than in the bone marrow cells, or to a greater cell-killing effect of high benzene concentrations on differentiating spermatogonia than on bone marrow cells (Ciranni et al, 1991).…”

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confidence: 99%

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Assessment of trans, trans-muconic acid in human seminal plasma

et al. 2001

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Summary Trans, trans‐muconic acid (tt‐MA) is one of the most important metabolites of benzene, a pollutant ubiquitously distributed in ambient air and classified in 1982 as a group I carcinogen. For its sensitivity and specificity, tt‐MA excreted in urine is considered a good biological marker of benzene exposure. In this study, seminal tt‐MA levels in occupationally nonexposed subjects (n = 32) have been determined. The seminal fluid of normozoospermic subjects contained an average tt‐MA concentration (170 ± 100 ng ml−1) significantly lower than that of teratozoospermic (310 ± 180 ng ml−1; P<0.01), oligozoospermic (400 ± 180 ng ml−1; P<0.001), and oligoasthenozoospermic (430 ± 230 ng ml−1; P<0.01) subjects. A negative correlation existed between tt‐MA levels and sperm concentration (r= — 0.62; P<0.001), percentage of normal spermatozoa (r= — 0.41; P<0.05), and percentage of vital spermatozoa (r= — 0.89; P<0.001). Average tt‐MA levels detected in seminal plasma were higher in smokers (350 ± 160 ng ml−1) than in nonsmokers (280 ± 210 ng ml−1). These results show that seminal plasma tt‐MA content could be an important biological indicator for evaluating the negative effects of benzene on spermatogenesis.

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

Assessment of trans, trans-muconic acid in human seminal plasma

et al. 2001

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“…One of the main reasons for this phenomenon might be the presence of toxic agents in the environment 25 . Work‐related activities frequently involve exposure to toxic chemicals, most of which are damaging to reproductive health and cause infertility in humans 26–29 . Occupational or accidental exposure to endocrine disrupters – chemical substances that interfere with synthesis, storage/release, transport, metabolism, binding, action or elimination of natural blood‐borne hormones responsible for the regulation of both homeostasis and developmental process – can lead to compromised fertility 30,31 …”

Section: Discussionmentioning

confidence: 99%

Antisperm antibodies in infertile men and their correlation with seminal parameters

Garcia

Rubio

Pereira

2007

Reprod Medicine & Biology

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Antisperm antibodies (ASA) in males cause the autoimmune disease 'immune infertility'. The present study intended to detect the presence of ASA and their incidence in men with unexplained infertility, as well as to evaluate the correlation between the presence of ASA and semen parameter alterations. Blood and sperm assessment were collected to carry out a direct and indirect mixed antiglobulin reaction (MAR) test and semen analysis in infertile and fertile men from the University Hospital of the Faculty of Medicine, Sao Paulo State University, Sao Paulo. In the MAR test, 18.18% of infertile men were positive for ASA. In fertile men, no positivity was found. A significant correlation between the presence of ASA with an increased white blood cell count plus a decreased hypoosmotic swelling test result was observed. The results indicate that ASA are involved in reduced fertility. It is not ASA detection that provides conclusive information about the occurrence of damage to fertility. The correlation between infertility and altered seminal parameters reinforce the ASA participation in this pathology. (Reprod Med Biol 2007; : 33-38).

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“…Reduced sperm counts have been documented in studies of men occupationally exposed to different environmental contaminants (De Celis et al 2000; Eskenazi et al 1991), but the relationship between dioxin exposure and semen quality remains ambiguous. No difference in semen quality was found in Taiwanese men exposed prenatally to rice oil contaminated with PCBs and polychlorinated dibenzofurans (Yu-Cheng accidental exposure), despite the occurrence of chloracne—clear evidence of AhR activation (Guo et al 2000).…”

Section: Epidemiologymentioning

confidence: 99%

Dioxin-Induced Changes in Epididymal Sperm Count and Spermatogenesis

Foster

Maharaj-Briceño

Cyr

2010

Environ Health Perspect

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BackgroundA single in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on gestation day 15 decreased epididymal sperm count in adult rats and thus was used to establish a tolerable daily intake for TCDD. However, several laboratories have been unable to replicate these findings. Moreover, conflicting reports of TCDD effects on daily sperm production suggest that spermatogenesis may not be as sensitive to the adverse effects of TCDD as previously thought.Data sourcesWe performed a PubMed search using relevant search terms linking dioxin exposure with adverse effects on reproduction and spermatogenesis.Data synthesisDevelopmental exposure to TCDD is consistently linked with decreased cauda epididymal sperm counts in animal studies, although at higher dose levels than those used in some earlier studies. However, the evidence linking in utero TCDD exposure and spermatogenesis is not convincing.ConclusionsAnimal studies provide clear evidence of an adverse effect of in utero TCDD exposure on epididymal sperm count but do not support the conclusion that spermatogenesis is adversely affected. The mechanisms underlying decreased epididymal sperm count are unknown; however, we postulate that epididymal function is the key target for the adverse effects of TCDD.

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Semen quality of workers occupationally exposed to hydrocarbons

Cited by 80 publications

References 24 publications

Assessment of trans, trans-muconic acid in human seminal plasma

Assessment of trans, trans-muconic acid in human seminal plasma

Antisperm antibodies in infertile men and their correlation with seminal parameters

Dioxin-Induced Changes in Epididymal Sperm Count and Spermatogenesis

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