Semen selenium and human fertility

Bleau, G.; Lemarbre, Jacques; Faucher, Guy; Roberts, Kenneth D.; Chapdelaine, A.

doi:10.1016/s0015-0282(16)48261-0

Cited by 80 publications

(6 citation statements)

References 5 publications

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“…Behne et al [7] reported that selenium stimulates LH and positively affects the biosynthesis of testosterone. In fact, Se is an important trace element that is crucial for male fertility and plays a role in sperm formation and development [19].…”

Section: Discussionmentioning

confidence: 99%

Selenium Nanoparticles Attenuate Oxidative Stress and Testicular Damage in Streptozotocin-Induced Diabetic Rats

et al. 2016

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Abstract:We investigated the protective and antioxidative effects of selenium nanoparticles (SeNPs) in streptozotocin STZ-induced diabetic rats. STZ-diabetic rats were exposed daily to treatments with SeNPs and/or insulin and then the effect of these treatments on the parameters correlated to oxidative damage of the rat testes were assessed. Biochemical analysis revealed that SeNPs are able to ameliorate the reduction in the serum testosterone caused by STZ-induced diabetes. Furthermore, SeNPs could significantly decrease testicular tissue oxidative stress markers, namely lipid peroxidation and nitric oxide. In contrast, treatment of the STZ-diabetic rats with SeNPs increased the glutathione content and antioxidant enzyme activities in testicular tissues. Moreover, microscopic analysis proved that SeNPs are able to prevent histological damage in the testes of STZ-diabetic rats. Molecular analysis revealed that the mRNA level of Bcl-2 (B-cell lymphoma 2) is significantly upregulated. On the contrary, the mRNA level of Bax (Bcl-2 Associated X Protein) was significantly downregulated. Furthermore, treatment of STZ-diabetic rats with SeNPs led to an elevation in the expression of PCNA (Proliferating Cell Nuclear Antigen Gene). Interestingly, the insulin treatment also exhibited a significant improvement in the testicular function in STZ-diabetic rats. Collectively, our results demonstrated the possible effects of SeNPs in attenuating diabetes-induced oxidative damage, in particular in testicular tissue.

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Section: Discussionmentioning

confidence: 99%

Selenium Nanoparticles Attenuate Oxidative Stress and Testicular Damage in Streptozotocin-Induced Diabetic Rats

et al. 2016

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“…It was detected that Se levels between 40 to 70 ng/mL were optimal for reproductive performance. However, Se levels below this range were associated with infertility, and above this range were associated with a high abortion rate, decreased motility, and asthenospermia [ 102 ]. These studies make evident the paradoxical effects of antioxidants on male fertility, which seem dose dependent.…”

Section: Antioxidants and Male Infertility—what Is Currently Known?mentioning

confidence: 99%

COVID-19 and Male Infertility: Is There a Role for Antioxidants?

Kalfas,

Kaltsas,

Symeonidis

et al. 2023

Antioxidants

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Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), jeopardizes male fertility because of the vulnerability of the male reproductive system, especially the testes. This study evaluates the effects of the virus on testicular function and examines the potential role of antioxidants in mitigating the damage caused by oxidative stress (OS). A comprehensive PubMed search examined exocrine and endocrine testicular function alteration, the interplay between OS and COVID-19-induced defects, and the potential benefit of antioxidants. Although the virus is rarely directly detectable in sperm and testicular tissue, semen quality and hormonal balance are affected in patients, with some changes persisting throughout a spermatogenesis cycle. Testicular pathology in deceased patients shows defects in spermatogenesis, vascular changes, and inflammation. Acute primary hypogonadism is observed mainly in severely infected cases. Elevated OS and sperm DNA fragmentation markers suggest redox imbalance as a possible mechanism behind the fertility changes. COVID-19 vaccines appear to be safe for male fertility, but the efficacy of antioxidants to improve sperm quality after infection remains unproven due to limited research. Given the limited and inconclusive evidence, careful evaluation of men recovering from COVID-19 seeking fertility improvement is strongly recommended.

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“…This is probably due to the capacity of zinc to neutralize superoxide ions [ 86 ]. Selenium is another trace element that is found to be decreased in non-normozoospermic men, when compared to the levels seen in fertile men [ 87 ]. The presence of this trace element, as well as zinc, in the seminal plasma was found to be positively correlated to total sperm motility, evidencing the role of trace elements in ROS neutralization for male fertility [ 88 ].…”

Section: Seminal Plasma Antioxidant Capabilities and Relation To Male Fertility Outcomesmentioning

confidence: 99%

Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

et al. 2021

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Nowadays, infertility is classified as a disease of the reproductive system. Although it does not compromise the life of the individual, it can have detrimental effects on the physiological and psychological health of the couple. Male fertility evaluation is mainly focused on the analysis of sperm parameters. However, the ejaculated fluid is also composed of seminal plasma, and the study of this fluid can provide crucial information to help in the assessment of male fertility status. Total antioxidant capacity of the seminal plasma has been positively correlated with the fertility of men. Moreover, evidence highlights to a similar importance as that of female reproductive tract fluid antioxidant capabilities and female fertility. Herein, we describe the functions of seminal plasma and female reproductive tract fluids, as well as their main antioxidant components and their relationships with fertility outcomes. Additionally, this review contains the most up to date information regarding the mechanisms of the interaction between the male and the female reproductive fluids and the importance of proper antioxidant capacity for fertilization.

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Semen selenium and human fertility

Cited by 80 publications

References 5 publications

Selenium Nanoparticles Attenuate Oxidative Stress and Testicular Damage in Streptozotocin-Induced Diabetic Rats

Selenium Nanoparticles Attenuate Oxidative Stress and Testicular Damage in Streptozotocin-Induced Diabetic Rats

COVID-19 and Male Infertility: Is There a Role for Antioxidants?

Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

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