Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota

Chen, Yanlan; Xiao, Nan; Chen, Yuxin; Chen, Xinye; Zhong, Chunfei; Cheng, Yuying; Du, Bing; Li, Pan

doi:10.1016/j.foodres.2021.110808

Cited by 16 publications

(29 citation statements)

References 62 publications

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“…Enrichment of Bacteroides can differentially impact susceptibility to depressive behaviors . Consistent with our findings, a previous study noted that Semen Sojae Praeparatum alleviated the CUMS-induced depressive behaviors while diminishing the abnormal enrichment of Bacteroides . As a sulfate-reducing bacterial genus, Desulfovibrio can degrade the intestinal mucin to produce hydrogen sulfide and eventually cause gastrointestinal diseases .…”

Section: Discussionsupporting

confidence: 90%

“…51 Consistent with our findings, a previous study noted that Semen Sojae Praeparatum alleviated the CUMS-induced depressive behaviors while diminishing the abnormal enrichment of Bacteroides. 52 As a sulfate-reducing bacterial genus, Desulfovibrio can degrade the intestinal mucin to produce hydrogen sulfide and eventually cause gastrointestinal diseases. 53 Correspondingly, consistency was observed between the recovery of intestinal barrier function and the reduction of Desulfovibrio in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Lactocaseibacillus rhamnosus zz-1 Supplementation Mitigates Depression-Like Symptoms in Chronic Stress-Induced Depressed Mice via the Microbiota–Gut–Brain Axis

Tang

Wang

et al. 2023

ACS Chem. Neurosci.

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Accumulating evidence has revealed an association between depression and disordered intestinal microecology. The discovery of psychobiotics has provided a promising perspective for studying the treatment of psychiatric disorders. Here, we aimed to investigate the antidepressant abilities of Lactocaseibacillus rhamnosus zz-1 (LRzz-1) and elucidate the underlying mechanisms. The viable bacteria (2 × 109 CFU/day) were orally supplemented to depressed C57BL/6 mice induced by chronic unpredictable mild stress (CUMS), and the behavioral, neurophysiological, and intestinal microbial effects were assessed, with fluoxetine used as a positive control. The treatment with LRzz-1 effectively mitigated the depression-like behavioral disorders of depressed mice and reduced the expression of inflammatory cytokine mRNA (IL-1β, IL-6, and TNF-α) in the hippocampus. In addition, LRzz-1 treatment also improved tryptophan metabolic disorder in the mouse hippocampus, as well as its peripheral circulation. These benefits are associated with the mediation of microbiome–gut–brain bidirectional communication. CUMS-induced depression impaired the intestinal barrier integrity and microbial homeostasis in mice, neither of which was restored by fluoxetine. LRzz-1 prevented intestinal leakage and significantly ameliorated epithelial barrier permeability by up-regulating tight-junction proteins (including ZO-1, occludin, and claudin-1). In particular, LRzz-1 improved the microecological balance by normalizing the threatened bacteria (e.g., Bacteroides and Desulfovibrio), exerting beneficial regulation (e.g., Ruminiclostridium 6 and Alispites), and modifying short-chain fatty acid metabolism. In summary, LRzz-1 showed considerable antidepressant-like effects and exhibited more comprehensive intestinal microecological regulation than other drugs, which offers novel insights that can facilitate the development of depression therapeutic strategies.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Lactocaseibacillus rhamnosus zz-1 Supplementation Mitigates Depression-Like Symptoms in Chronic Stress-Induced Depressed Mice via the Microbiota–Gut–Brain Axis

Tang

Wang

et al. 2023

ACS Chem. Neurosci.

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“…It upregulated the levels of 5-HT, BDNF, and GABA in the hippocampus. Furthermore, Semen Sojae Praeparatum is a novel therapeutic agent against depression, according to a theoretical investigation of the relationship between the microbiota–gut–brain axis and antidepressants [ 163 ]. A recent study revealed that a Zhi-Zhi-Chi decoction consisting of Semen Sojae Praeparatum and Gardenia fructus shows an antidepressant effect by altering the gut microbiota to promote butyrate synthesis, which in turn regulates BDNF, neurotransmitters, endocrine, and anti-inflammatory responses along the gut–brain axis.…”

Section: Resultsmentioning

confidence: 99%

“…However, the exact mechanism of action of BDNF in the gut remains unknown for most natural products [ 78 , 91 , 94 , 102 , 112 ]. Many animal and clinical studies have been conducted to determine the crucial effects of natural products on depression and neuroprotection; however, the constituents of these products remain mainly unknown [ 155 , 159 , 160 , 162 , 163 ]. Future studies are necessary to identify the constituents of Tualang honey, Semen Sojae Praeparatum, Cocos nucifera husk fiber, and HJDT.…”

Section: Discussionmentioning

confidence: 99%

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Liaqat

Parveen

Kim

2022

IJMS

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Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.

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“…Semen sojae praeparatum is a traditional fermented food and showed anti-depressive effects through modulating the microbiota–gut–brain axis. Specifically, Semen sojae praeparatum upregulated the abundance of the genus Ruminococcaceae_UCG-008 and regulated serotonin, norepinephrine, GABA, and BDNF content in the hippocampus [ 89 ].…”

Section: Depressionmentioning

confidence: 99%

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Zhou

et al. 2022

Antioxidants

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Depression and anxiety are severe public health problems and have attracted more and more attention from researchers of food science and nutrition. Dietary natural products and nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, and dietary fiber, could play a vital role in the prevention and management of these diseases. The potential mechanisms of action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating the microbiota–gut–brain axis, suppressing hypothalamic–pituitary–adrenal axis hyperactivity, and regulating the levels of monoamine neurotransmitters. In this narrative review, we summarize the most recent advancements regarding the effects of dietary natural products and nutrients on depression and anxiety, and their underlying mechanisms are discussed. We hope that this paper can provide a better understanding of the anti-depressive and anxiolytic action of dietary natural products, and that it is also helpful for developing dietary natural products for functional food, dietary supplements, or auxiliary agents for the prevention and management of these diseases.

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Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota

Cited by 16 publications

References 62 publications

Lactocaseibacillus rhamnosus zz-1 Supplementation Mitigates Depression-Like Symptoms in Chronic Stress-Induced Depressed Mice via the Microbiota–Gut–Brain Axis

Lactocaseibacillus rhamnosus zz-1 Supplementation Mitigates Depression-Like Symptoms in Chronic Stress-Induced Depressed Mice via the Microbiota–Gut–Brain Axis

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

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