Investigation of breakdown pressure in wellbores in complex conditions is of great importance, both in fracture design and in wellbore log interpretation for in situ stress estimation. In this research, using a two-dimensional numerical model, the breakdown pressure is determined in ellipsoidal and breakout wellbores. To find the breakdown pressure, the mixed criterion is used, in which the toughness and the tensile strength criteria must be satisfied concurrently. In breakout boreholes, the breakdown pressure is lower than the circular wellbores; indeed, the ratio of the breakdown pressure of the breakout wellbore to the breakdown pressure in the circular wellbore is between 1 and 0.04, depending on the deviatoric stress and the width and depth of the breakout zone. In breakout wellbores, the fracture initiation position depends on the deviatoric stress. In small deviatoric stresses, the fracture initiation position is aligned with the minimum in situ stress, unlike circular boreholes; and in large deviatoric stresses, the fracture initiates in the direction of the major principal stress. In large wellbores, the breakdown pressure is controlled by the tensile strength of the rock; and in small wellbores, the breakdown pressure is under the control of the energy spent to create new crack surfaces.