Semi-automated scoring of pulmonary emphysema from X-ray CT: Trainee reproducibility and accuracy

Owrangi, Amir; Entwistle, Brandon; Lu, Andrew; Chiu, Jack; Hussain, Nabil; Etemad-Rezai, Roya; Párraga, Grace

doi:10.1016/j.ejrad.2013.07.013

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…In this regard, our methodology was similar to that in other studies examining interreader performance in diagnostic imaging with and without an intervention such as computer-aided diagnostic software. Parallel methodology has been used in lung disease, [39][40][41][42][43] breast imaging, 29,[44][45][46] and Alzheimer disease, 26,47 without determining intraobserver variability.…”

Section: 712mentioning

confidence: 99%

Use of Standardized Uptake Value Ratios Decreases Interreader Variability of [18F] Florbetapir PET Brain Scan Interpretation

Nayate

Dubroff

Schmitt

et al. 2015

American Journal of Neuroradiology

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Section: 712mentioning

confidence: 99%

Use of Standardized Uptake Value Ratios Decreases Interreader Variability of [18F] Florbetapir PET Brain Scan Interpretation

Nayate

Dubroff

Schmitt

et al. 2015

American Journal of Neuroradiology

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“…Future studies are needed to validate these findings in larger cohorts of HIV+ patients, which may be possible with the introduction of automated CT emphysema scoring. 46, 47 This study also highlights the need for further investigations to delineate inflammatory pathways involved in emphysema in HIV and trials to determine whether HIV+ individuals with mild emphysema, in the absence of airflow limitation, would benefit from treatment with therapies traditionally directed against COPD.…”

Section: Resultsmentioning

confidence: 90%

The Differential Impact of Emphysema on Respiratory Symptoms and 6-Minute Walk Distance in HIV Infection

Triplette

Attia

Akgün

et al. 2017

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background Emphysema is more prevalent in HIV-infected (HIV+) patients independent of smoking behavior. Nonetheless, health effects of emphysema in this population are poorly understood. We determined whether emphysema is associated with a greater burden of pulmonary symptoms and a lower six-minute walk distance (6MWD) in HIV+ compared to HIV-uninfected (HIV−) subjects. Methods We performed a cross-sectional analysis of 170 HIV+ and 153 HIV− subjects in the Examinations of HIV Associated Lung Emphysema (EXHALE) cohort study. Subjects completed a self-assessment of respiratory symptoms, pulmonary function testing, and 6MWD testing as well as a CT scan to determine emphysema severity. We used regression models to determine the association of emphysema with respiratory symptoms and 6MWD in HIV+ subjects and compared this to HIV− subjects. Results Models stratified by HIV status demonstrated an association between >10% radiographic emphysema and chronic cough and/or phlegm and 6MWD in HIV+ subjects. These associations persisted among the subset without airflow obstruction: those with emphysema had 4.2 (95% CI 1.3, 14) times the odds of chronic cough and/or phlegm and walked 60m (95% CI 26, 93) less distance than those without emphysema. There was no association between >10% emphysema and symptoms or 6MWD in HIV− subjects. Conclusions In our cohort, >10% radiographic emphysema was associated with chronic cough and phlegm and lower 6MWD in HIV+ but not HIV− subjects. These findings were robust even amongst HIV+ subjects with milder forms of emphysema and those without airflow obstruction, highlighting the clinical impact of emphysema in these patients.

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“…The authors note that, with this software, high-resolution CT can be applied for an earlier window into COPD progression [2]. An automated emphysema score using principal component analysis with CT shows strong correlations with objective measures of COPD severity and facilitates strong intra-and inter-rater reliability independent of clinical experience in a small study [3]. Thomsen and colleagues also attempt to classify COPD using ''causal probabilistic networks,'' or Bayesian networks.…”

Section: Diagnosismentioning

confidence: 99%

New Technologies in COPD Management

Spencer¹,

Barcomb²

2014

Curr Emerg Hosp Med Rep

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Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating disease that affects millions of Americans. Numerous technological advances have been made recently in this field. This article reviews the use of novel technologies in COPD patients, focusing on the medical literature from 2013. These advances affect the diagnosis, the management of acute exacerbations, and the long-term, outpatient care of this condition. Diagnostic advances are examined such as novel applications of computed tomography, plethysmography, and analysis of the breath. Acute interventions include oxygen therapy, extracorporeal gas exchange, and molecular or nanotechnology. Finally, a preponderance of recent literature focuses on telemedicine to facilitate monitoring and treatment. Emerging technologies have a significant potential to positively impact patient care.

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Semi-automated scoring of pulmonary emphysema from X-ray CT: Trainee reproducibility and accuracy

Cited by 4 publications

References 32 publications

Use of Standardized Uptake Value Ratios Decreases Interreader Variability of [18F] Florbetapir PET Brain Scan Interpretation

Use of Standardized Uptake Value Ratios Decreases Interreader Variability of [18F] Florbetapir PET Brain Scan Interpretation

The Differential Impact of Emphysema on Respiratory Symptoms and 6-Minute Walk Distance in HIV Infection

New Technologies in COPD Management

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