A set of reinforced concrete structures with gravitational loads and mechanical properties (strength and stiffness) representative of systems designed for earthquake resistance in accordance with current criteria and methods is selected to study the influence of dynamic soil-structure interaction on seismic response, ductility demands and reliability levels. The buildings are considered located at soft soil sites in the Valley of Mexico and subjected to ground motion time histories simulated in accordance with characteristic parameters of the maximum probable earthquake likely to occur during the system's expected life. For the near-resonance condition the effects of soil-structure interaction on the ductility demands depend mainly on radiation damping. According to the geometry of the structures studied this damping is strongly correlated with the aspect ratio, obtained by dividing the building height by its width. In this way, for structures with aspect ratio greater than 1.4 the storey and global ductility demands increase with respect to those obtained with the same structures but on rigid base, while for structures with aspect ratio less than 1.4 the ductility demands decrease with respect to those for the structures on rigid base. For the cases when the fundamental period of the structure has values very different from the dominant ground period, soil-structure interaction leads in all cases to a reduction of the ductility demands, independently of the aspect ratio. The reliability index is obtained as a function of the base shear ratio and of the seismic intensity acting on the nonlinear systems subjected to the simulated motions. The resulting reliability functions are very similar for systems on rigid or on flexible foundation, provided that in the latter case the base rotation and the lateral displacement are removed from the total response of the system. Several groups of ductile reinforced concrete beam-column frame buildings are studied. They include six-, ten-, fourteen-and twenty-storey systems. There are two ten-storey systems, with two and three bays, respectively; three fourteen-storey systems, with two, three and five bays. All six-and twenty-storey systems have three bays in width. In all cases the bay width is equal to 7.0 m, centre to centre, and the storey height is equal to 3.5 m for the bottom storey and 3.0 m for all the others, except for the twenty-storey system, for which these heights are 0.2 m greater. Sketches of the building configurations are shown elsewhere [2]. The responses obtained for the three-bay systems are applied to the study of the variation of the influence of the DSSI with the period of the structure for the different soil conditions considered. The results obtained for the ten-and fourteen-storey systems, with different numbers of bays, are used to study the influence of the aspect ratio.Each system is designated by the number of stories (#S) and the number of bays (#B). (For instance, the ten-storey three-bay system is designated as 10S-3B). All systems are regular...