Semi-enzymatic synthesis of somatostatin

Bille, Vincent; Ripak, C.; Assche, I. Van; Forni, Luciana; Degelaen, J.; Scarso, A.

doi:10.1007/978-94-011-3034-9_107

Cited by 6 publications

(4 citation statements)

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“…Previously, oligopeptides having various functions were synthesized using protease catalyst via condensation reactions in either a thermodynamically controlled or a kinetically controlled manner . For example, aspartame (Asp-Phe) by thermolysin, oxytocin (Cys-Tyr-Tyr-Ile-Pro-Leu-Leu-Gly) by papain, thermolysin, and chymotrypsin, and somatostatin (cyclic,-Ala-Gly-Cys-Lys-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-) by thermolysin and chymotrypsin were prepared as typical biologically active peptides.…”

Section: Hydrolasesmentioning

confidence: 99%

Enzymes as Green Catalysts for Precision Macromolecular Synthesis

et al. 2016

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The present article comprehensively reviews the macromolecular synthesis using enzymes as catalysts. Among the six main classes of enzymes, the three classes, oxidoreductases, transferases, and hydrolases, have been employed as catalysts for the in vitro macromolecular synthesis and modification reactions. Appropriate design of reaction including monomer and enzyme catalyst produces macromolecules with precisely controlled structure, similarly as in vivo enzymatic reactions. The reaction controls the product structure with respect to substrate selectivity, chemo-selectivity, regio-selectivity, stereoselectivity, and choro-selectivity. Oxidoreductases catalyze various oxidation polymerizations of aromatic compounds as well as vinyl polymerizations. Transferases are effective catalysts for producing polysaccharide having a variety of structure and polyesters. Hydrolases catalyzing the bond-cleaving of macromolecules in vivo, catalyze the reverse reaction for bond forming in vitro to give various polysaccharides and functionalized polyesters. The enzymatic polymerizations allowed the first in vitro synthesis of natural polysaccharides having complicated structures like cellulose, amylose, xylan, chitin, hyaluronan, and chondroitin. These polymerizations are "green" with several respects; nontoxicity of enzyme, high catalyst efficiency, selective reactions under mild conditions using green solvents and renewable starting materials, and producing minimal byproducts. Thus, the enzymatic polymerization is desirable for the environment and contributes to "green polymer chemistry" for maintaining sustainable society.

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Section: Hydrolasesmentioning

confidence: 99%

Enzymes as Green Catalysts for Precision Macromolecular Synthesis

et al. 2016

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“…Oligopeptides having various functions have been synthesized extensively using proteases as catalyst via condensation reactions in either a thermodynamically controlled or a kinetically controlled manner . For examples, aspartame (Asp-Phe) by thermolysin, oxytocin (Cys-Tyr-Tyr-Ile-Pro-Leu-Leu-Gly) by papain, thermolysin, and chymotrypsin, and somatostatin (cyclic, -Ala-Gly-Cys-Lys-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-) by thermolysin, and chymotrypsin, were prepared as typical biologically active peptides.…”

Section: Synthesis Of Polycarbonates Polyamides Polyphosphates and Po...mentioning

confidence: 99%

Enzymatic Polymer Synthesis: An Opportunity for Green Polymer Chemistry

2009

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“…There exist several oligopeptides with varied biologically active properties that have been synthesized widely using proteases as catalysts via condensation reactions [ 169 ]. Some examples include, aspartame synthesized by thermolysin [ 170 ], oxytocin by papain, thermolysin, and chymotrypsin, and somatostatin by thermolysin, and chymotrypsin [ 171 ]. Various attempts to synthesize long-chain polyaminoamides were done by a protease-catalyzed polycondensation using chymotrypsin, trypsin, subtilisin and papain.…”

Section: Enzymes In the Bulk Chemistry Industrymentioning

confidence: 99%

Biocatalysis for Biobased Chemicals

Regil¹,

Sandoval²

2013

Biomolecules

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The design and development of greener processes that are safe and friendly is an irreversible trend that is driven by sustainable and economic issues. The use of Biocatalysis as part of a manufacturing process fits well in this trend as enzymes are themselves biodegradable, require mild conditions to work and are highly specific and well suited to carry out complex reactions in a simple way. The growth of computational capabilities in the last decades has allowed Biocatalysis to develop sophisticated tools to understand better enzymatic phenomena and to have the power to control not only process conditions but also the enzyme’s own nature. Nowadays, Biocatalysis is behind some important products in the pharmaceutical, cosmetic, food and bulk chemicals industry. In this review we want to present some of the most representative examples of industrial chemicals produced in vitro through enzymatic catalysis.

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Semi-enzymatic synthesis of somatostatin

Cited by 6 publications

References 0 publications

Enzymes as Green Catalysts for Precision Macromolecular Synthesis

Enzymes as Green Catalysts for Precision Macromolecular Synthesis

Enzymatic Polymer Synthesis: An Opportunity for Green Polymer Chemistry

Biocatalysis for Biobased Chemicals

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