Semi-interpenetrating hydrogels from carboxymethyl guar gum and gelatin for ciprofloxacin sustained release

Ghosh, Sumanta Kumar; Das, Asish R.; Basu, Aalok; Halder, Asim; Das, Suvadra; Basu, Sreyasree; Abdullah, Md. Farooque; Mukherjee, Arup; Kundu, Sonia

doi:10.1016/j.ijbiomac.2018.09.212

Cited by 66 publications

(14 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can be justified by the fact that the proposed model is known to be based on Fick's law and thus is applicable once both the thickness of the specimens and the diffusion coefficient within the hydrogels (D) remain constant throughout the swelling experiment. [31] This is contrary to the situation seen in this paper where the volume of the hydrogels changed upon the water uptake. The swelling behavior of the specimens was also studied by Schott's kinetic model, which is a second-order description of water uptake kinetics.…”

Section: Swelling Kineticscontrasting

confidence: 75%

“…Water uptake kinetics of the crosslinked composite hydrogels were studied in order to further our knowledge on the amount of fluid that could be absorbed at various time intervals (t) during incubation in PBS solution (pH = 7.4) at 37 C. It was generally assumed that swelling kinetics of the hydrogels followed the first-order kinetic model, and therefore, it can be described using the following equation [31] :…”

Section: Swelling Kinetics Analysismentioning

confidence: 99%

“…The water absorption rate of the hydrogels was also studied by the pseudo-second-order kinetic model (Schott's model), which is expressed as follows [31,32] :…”

Section: Swelling Kinetics Analysismentioning

confidence: 99%

See 2 more Smart Citations

Fabrication, swelling behavior, and water absorption kinetics of genipin‐crosslinked gelatin–chitosan hydrogels

Moshayedi

Sarpoolaky

Khavandi

2021

Polymer Engineering & Sci

View full text Add to dashboard Cite

Gelatin/chitosan hydrogels have attracted considerable attention over the last 2 decades in various fields of applications. In this paper, chemically crosslinked composite hydrogels with different gelatin-to-chitosan weight ratios were fabricated and crosslinked with different amounts of genipin via the solvent casting technique combined with freeze-drying. Fourier-transform infrared, scanning electron microscopy (SEM), liquid displacement method, and gravimetric analysis were used to examine the chemical, microstructural, and physical properties of the hydrogels. IR spectra confirmed the formation of covalent bonds between the amino groups of the parent's macromolecules and genipin. SEM micrographs indicated that the hydrogels possessed a highly porous structure with well-defined pore geometries. The swelling capacity and degradation rate of the specimens reduced with increasing the amounts of chitosan and/or genipin. In-depth swelling measurements revealed that the first-order kinetic model was only applicable in the early stage of the swelling study; however, the water absorption behavior of the hydrogels was best described by the pseudo-second-order kinetic model (Schott's model) throughout the swelling experiment. The genipin-crosslinked hydrogels were found to support MC3T3-E1 cell proliferation. The results of this paper thus suggest the 1.5% genipin-crosslinked gelatin/chitosan hydrogels as promising candidates for on-demand drug delivery applications or more precisely osteoarthritis drug delivery systems.

show abstract

Section: Swelling Kineticscontrasting

confidence: 75%

Section: Swelling Kinetics Analysismentioning

confidence: 99%

See 1 more Smart Citation

Fabrication, swelling behavior, and water absorption kinetics of genipin‐crosslinked gelatin–chitosan hydrogels

Moshayedi

Sarpoolaky

Khavandi

2021

Polymer Engineering & Sci

View full text Add to dashboard Cite

show abstract

“…A remarkable change in physical properties was observed which depending upon chain length of carboxylic acid and substitution degree. It was demonstrated that the extent of reaction depends upon reactivity of acid chloride, which in turn increases with chain length of fatty acid [28,29]. The greater the DS value, the greater the organo-soluble capacity.…”

Section: Resultsmentioning

confidence: 99%

Green and Environmentally Friendly Techniques for Enhanced Physicochemical Characteristics Attributed to Polysaccharides for Industrial Applications

Iqbal¹,

Hussain²,

Bukhari³

et al. 2020

Pol. J. Environ. Stud.

View full text Add to dashboard Cite

Guar esters of long-chain aliphatic carboxylic acids (fatty acid) were prepared and examined. Esterification was done in two steps, with the first goal to prepare acid chloride by refluxing acid with slight excess of thionyl chloride, and the product was confirmed by elemental analysis. Ten different types of fatty acid (C 5 -C 18 ) were used for derivatization. The reaction mechanism for synthesis of fatty acid ester of guar was studied in detail. Physical properties of the esters were examined as well. The degree of substitution was calculated by titration method and structure elucidation was done using Fourier transform infrared spectroscopy (FTIR), proton-nuclear magnetic resonance ( 1 H-NMR) and scanning electron microscopy (SEM) techniques.

show abstract

“…In the preparation of the gelatin hydrogel, which was the base material in this study, the concentration of the crosslinking agent plays a very important role in drug or protein loading. 38 Tran et al reported that covalent imine bonds were formed between aldehyde groups in the cross-linker (glutaraldehyde) and the amino groups in gelatin when concentration of glutaraldehyde added in the gelatin became higher. 39 It also makes a strong network structure, while a smaller amount of glutaraldehyde loosens this network structure.…”

Section: Discussionmentioning

confidence: 99%

Osteogenic Effect of a Biodegradable BMP-2 Hydrogel Injected into a Cannulated Mg Screw

Kim

Chong

et al. 2020

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Cannulated screws, containing an internal hole for inserting a guide pin, are commonly used in the management of bone fractures. Cannulated Mg screws can be biodegraded easily because their increased surface area including that of the inner hole rapidly reacts with body fluids. To delay biodegradation of cannulated Mg screws and improve bone regeneration, we developed a specific type of screw by injecting it with gelatin hydrogels [10 wt % gelatin(gel) with 0.09 v/v % glutaraldehyde (cross-linker)] containing different concentrations (5, 10, or 25 μg/mL) of bone morphogenic proteins (BMPs). We analyzed the properties and biocompatibility of the screws with and without BMP-2 and found that the release rate of BMP-2 in the hydrogel changed proportionately with the degradation rate of the cross-linked hydrogel. Loading BMP-2 in the hydrogel resulted in sustained release of BMP-2 for 25 to 40 days or more. The degradation rate of BMP-2 hydrogels was inversely proportional to the concentration of BMP-2. The injection of the hydrogels in the cannulated screw delayed biodegradation inside of the screw by simulated body fluid. It also induced uniform corrosion and the precipitation of bioactive compounds onto the surface of the screw. In addition, osteoblast proliferation was very active near the BMP-2 hydrogels, depending on the BMP-2 concentration. The BMP-2 in the hydrogel improved cell differentiation. The cannulated screw injected with 10 μL/mL BMP-2 hydrogel prevented implant biodegradation and enhanced osteoconduction and osteointegration inside and outside the screw. In addition, the properties of BMP-2-loaded hydrogels can be changed by controlling the amount of the cross-linker and protein, which could be useful for tissue regeneration in other fields.

show abstract

Semi-interpenetrating hydrogels from carboxymethyl guar gum and gelatin for ciprofloxacin sustained release

Cited by 66 publications

References 56 publications

Fabrication, swelling behavior, and water absorption kinetics of genipin‐crosslinked gelatin–chitosan hydrogels

Fabrication, swelling behavior, and water absorption kinetics of genipin‐crosslinked gelatin–chitosan hydrogels

Green and Environmentally Friendly Techniques for Enhanced Physicochemical Characteristics Attributed to Polysaccharides for Industrial Applications

Osteogenic Effect of a Biodegradable BMP-2 Hydrogel Injected into a Cannulated Mg Screw

Contact Info

Product

Resources

About