Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)

Chincarini, A.; Peira, Enrico; Morbelli, Silvia; Pardini, Matteo; Bauckneht, Matteo; Arbizu, Javier; Castelo‐Branco, Miguel; Büsing, Karen A.; Mendonça, Alexandre de; Didic, Mira; Dottorini, Massimo E.; Engelborghs, Sebastiaan; Ferrarese, Carlo; Frisoni, Giovanni B.; Garibotto, Valentina; Guedj, Eric; Hausner, Lucrezia; Hugon, Justine; Verhaeghe, Jeroen; Mecocci, P.; Musarra, Monica; Queneau, Mathieu; Riverol, Mario; Santana, Isabel; Guerra, Ugo Paolo; Nobili, Flavio

doi:10.1016/j.nicl.2019.101846

Cited by 24 publications

(20 citation statements)

References 36 publications

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“…In cases with low amyloid load, similar to those included in our series, the use of SUVR values may lead to an overestimation of cortical amyloid burden 51 . Our findings are close to those reported by Chincarini et al 22 using a semi-quantitative approach (ELBA) based on the evaluation of the whole brain without specific regions of interest. However, this method was operator-dependent and no data are available on its association with cognitive decrement over time.…”

Section: Discussionsupporting

confidence: 90%

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PET amyloid in normal aging: direct comparison of visual and automatic processing methods

Haller

Montandon

Lilja

et al. 2020

Sci Rep

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Assessment of amyloid deposits is a critical step for the identification of Alzheimer disease (AD) signature in asymptomatic elders. Whether the different amyloid processing methods impacts on the quality of clinico-radiological correlations is still unclear. We directly compared in 155 elderly controls with extensive neuropsychological testing at baseline and 4.5 years follow-up three approaches: (i) operator-dependent standard visual reading, (ii) operator-independent automatic SUVR with four different reference regions, and (iii) novel operator and region of reference-independent automatic Aβ-index. The coefficient of variance was used to examine inter-individual variability for each processing method. Using visually-established amyloid positivity as the gold standard, the area under the receiver operating characteristic curve (ROC) was computed. Linear regression models were used to assess the association between changes in continuous cognitive score and amyloid uptake values. In SUVR analyses, the coefficient of variance varied from 1.718 to 1.762 according to the area of reference and was of − 3.045 for the Aβ-index method. Compared to the visual rating, Aβ-index method showed the largest area under the ROC curve [0.9568 (95% CI 0.9252, 0.98833)]. The best cut-off score was of − 0.3359 with sensitivity and specificity values of 0.97 and 0.83, respectively. Only the Aß-index was related to more severe decrement of cognitive performances [regression coefficient: 9.103 (95% CI 1.148, 17.058)]. The Aβ-index is considered as preferred option in asymptomatic elders, since it is operator-independent, avoids the selection of reference area, is closer to established visual scoring and correlates with the evolution of cognitive performances.

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Section: Discussionsupporting

confidence: 90%

“…More recently developed methods rely on user-and region-independent strategies for the assessment of amyloid load 22 . In particular, the Aβ-index derived from the method described by Lilja et al 23 combines the advantages of an automatic, user-independent data processing with an independence of the selection of a reference region.…”

mentioning

confidence: 99%

PET amyloid in normal aging: direct comparison of visual and automatic processing methods

Haller

Montandon

Lilja

et al. 2020

Sci Rep

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“…harvard.edu/). This includes segmentation of the subcortical white-matter and deep gray-matter volumetric structures [58] and parcellation of the cortical surface [59]. This labels cortical sulci and gyri, and thickness values are calculated in the regions of interest.…”

Section: Mri Segmentations and Analysesmentioning

confidence: 99%

No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study

et al. 2020

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Background: Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI is unclear. We hypothesize that amyloid deposition, measured with Flutemetamol (18 F-Flut) positron emission tomography (PET), is common in seven-year stroke survivors diagnosed with CI and, further, that quantitatively assessed 18 F-Flut-PET uptake after 7 years correlates with amyloid-β peptide (Aβ 42) levels in cerebrospinal fluid (CSF) at 1 year, and with measures of neurodegeneration and cognition at 7 years post-stroke. Methods: 208 patients with first-ever stroke or transient Ischemic Attack (TIA) without pre-existing CI were included during 2007 and 2008. At one-and seven-years post-stroke, cognitive status was assessed, and categorized into dementia, mild cognitive impairment or normal. Etiologic sub-classification was based on magnetic resonance imaging (MRI) findings, CSF biomarkers and clinical cognitive profile. At 7 years, patients were offered 18 F-Flut-PET, and amyloid-positivity was assessed visually and semi-quantitatively. The associations between 18 F-Flut-PET standardized uptake value ratios (SUVr) and measures of neurodegeneration (medial temporal lobe atrophy (MTLA), global cortical atrophy (GCA)) and cognition (Mini-Mental State Exam (MMSE), Trail-making test A (TMT-A)) and CSF Aβ 42 levels were assessed using linear regression. Results: In total, 111 patients completed 7-year follow-up, and 26 patients agreed to PET imaging, of whom 13 had CSF biomarkers from 1 year. Thirteen out of 26 patients were diagnosed with CI 7 years post-stroke, but only one had visually assessed amyloid positivity. CSF Aβ 42 levels at 1 year, MTA grade, GCA scale, MMSE score or TMT-A at 7 years did not correlate with 18 F-Flut-PET SUVr in this cohort. Conclusions: Amyloid binding was not common in 7-year stroke survivors diagnosed with CI. Quantitatively assessed, cortical amyloid deposition did not correlate with other measures related to neurodegeneration or cognition. Therefore, amyloid pathology may not be a key mediator of neurodegeneration 7 years post-stroke.

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“…harvard.edu/). This includes segmentation of the subcortical white-matter and deep gray-matter volumetric structures (57) and parcellation of the cortical surface (58). This labels cortical sulci and gyri, and thickness values are calculated in the regions of interest.…”

Section: Mri Segmentations and Analysesmentioning

confidence: 99%

No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven year follow-up study

Hagberg

Ihle‐Hansen²,

Fure

et al. 2020

Preprint

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Background Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI is unclear. We hypothesize that amyloid deposition, measured with Flutemetamol ( 18 F-Flut) positron emission tomography (PET), is common in 7-year stroke survivors diagnosed with CI and, further, that quantitatively assessed 18 F-Flut-PET uptake after seven years correlates with amyloid-β peptide (Aβ 42 ) levels in cerebrospinal fluid (CSF) at one year, and with measures of neurodegeneration and cognition at seven years post-stroke. Methods 208 patients with first-ever stroke or TIA without pre-existing CI were included during 2007 and 2008. At one- and seven-years post-stroke, cognitive status was assessed, and categorized into dementia, mild cognitive impairment or none. Etiologic sub-classification was based on magnetic resonance imaging (MRI) findings, CSF biomarkers and clinical cognitive profile. At seven years, patients were offered 18 F-Flut-PET, and amyloid-positivity was assessed visually and semi-quantitatively. The associations between 18 F-Flut-PET standardized uptake value ratios (SUVr) and measures of neurodegeneration (medial temporal lobe atrophy (MTLA), global cortical atrophy (GCA)) and cognition (Mini-Mental State Exam (MMSE), Trail-making test A (TMT-A)) and CSF Aβ 42 levels were assessed using linear regression. Results In all, 111 patients completed 7-year follow-up, and 26 patients agreed to PET imaging, of whom 13 had CSF biomarkers from one year. Thirteen out of 26 patients were diagnosed with CI seven years post-stroke, but only one had visually assessed amyloid positivity. CSF Aβ 42 levels at one year, MTA grade, GCA scale, MMSE score or TMT-A at seven years did not correlate with 18 F-Flut-PET SUVr in this cohort. Conclusions Amyloid binding were not common in 7-year stroke survivors diagnosed with CI. Quantitatively assessed amyloid did not correlate with other measures related to neurodegeneration and cognition. Therefore amyloid pathology may not be a key mediator of neurodegeneration seven years post-stroke.

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Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)

Cited by 24 publications

References 36 publications

PET amyloid in normal aging: direct comparison of visual and automatic processing methods

PET amyloid in normal aging: direct comparison of visual and automatic processing methods

No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study

No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven year follow-up study

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