In the present work, the influence of Cu content on microstructure, mechanical properties and exfoliation corrosion behaviors of Al-Zn-Mg-xCu alloy extrusions has been investigated in longitudinal-transverse (L-T) and short-longitudinal (S-L) directions by means of mechanical tensile and exfoliation corrosion testing combined with optical microscopy (OM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results showed that a higher Cu content significantly decreased the fracture toughness and ductility of the alloy in S-L direction compared with L-T direction. Concomitant with the increase in Cu content, a transition in fracture mode was observed from transgranular dimpled rupture to intergranular rupture in S-L direction. Moreover, the exfoliation corrosion (EXCO) resistance of the alloy decreased as the Cu content increased and the exfoliation corrosion resistance of the alloy in short-transverse (S-T) direction was better than that of L-T direction. These results were mainly associated with the large number of coarse intermetallics caused by high Cu content in the L-T direction of alloy.Boeing 787 and Airbus A380 aircraft [5][6][7]. With the development of aerospace industry, the demand for large-sized cross-section components (especially thick plates) is becoming more and more urgent and the requirements such as hardenability and mechanical property uniformity of the alloy are also becoming stricter [8][9][10]. Wu et al.'s research showed that the anisotropy of fatigue crack propagation was ascribed to the coarse inclusion particles and T 1 precipitates [11]. Jata et al. suggested that the yield stress anisotropy may be due to the combined synergistic effect of particles and crystallographic texture [12]. Hu et al. showed that the occurrence of the anisotropy in over-aged 7050 aluminum alloy was mainly attributed to the microstructures, which were further characterized by visible precipitate free zones (PFZs) and coarse precipitates in (sub)grain boundaries [13]. However, there are few studies on the influence of alloy composition on the anisotropy of mechanical properties for Al-Zn-Mg-Cu aluminum alloy thick plate or forging, such as the Cu element. As the main alloying element of Al-Zn-Mg-Cu alloy, Cu has its solid solution strengthening effect and its addition could change the precipitation phase structure of the alloy and make the aging precipitates more dispersed and uniform, which could improve the strength and plasticity of the alloy. However, as the content of Cu increases, the alloy will have a problem of high corrosion sensitivity. Marlaud et al. observed that the precipitates were easy coarsening in the lower Cu-containing alloy due to slower diffusivity of Cu in Al compared to Mg and Zn atoms [14]. Knight et al. believed that the reduction of quenching rate contributed to the increase of Cu content in grain boundary, thereby improving the stress corrosion resistance [15]. It has also been reported that the increase of Cu content in the alloy would lead to an incre...