Semi-quantitative scoring of skeletal metastases by 123I-mIBG scintigraphy in high-risk neuroblastoma

Gaze, Mark

doi:10.1007/s00259-017-3660-1

Cited by 2 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Selection of the targeted radiopharmaceutical for treatment is typically based on the use of imaging biomarkers. Semi-quantitative assessment of the uptake of mIBG using 123 I-mIBG scintigraphy is used for the staging and response assessment of neuroblastoma, 103 and avid uptake into known sites of disease is an essential prerequisite for 131 I-mIBG therapy. Similarly in neuroendocrine cancers, the demonstration by PET-CT of the uptake of 68 Ga-DOTATATE into tumours with a greater standardised uptake value (SUV) than in liver is required before proceeding to 177 Lu-DOTATATE therapy.…”

Section: Image Guidance and Advances In Radiotherapy Deliverymentioning

confidence: 99%

How rapid advances in imaging are defining the future of precision radiation oncology

et al. 2019

Self Cite

View full text Add to dashboard Cite

Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imaging might enable higher doses of radiation to be delivered to the tumour, while sparing normal surrounding tissues. In this article, we review how the integration of existing and novel forms of computed tomography, magnetic resonance imaging and positron emission tomography have transformed tumour delineation in the radiotherapy planning process, and how these advances have the potential to allow a more individualised approach to the cancer therapy. Recent data suggest that imaging biomarkers that assess underlying tumour heterogeneity can identify areas within a tumour that are at higher risk of radio-resistance, and therefore potentially allow for biologically focussed dose escalation. The rapidly evolving concept of adaptive radiotherapy, including artificial intelligence, requires imaging during treatment to be used to modify radiotherapy on a daily basis. These advances have the potential to improve clinical outcomes and reduce radiation-related long-term toxicities. We outline how recent technological advances in both imaging and radiotherapy delivery can be combined to shape the future of precision radiation oncology.

show abstract

Section: Image Guidance and Advances In Radiotherapy Deliverymentioning

confidence: 99%