Semi-Synthetic Thymoquinone Analogs: New Prototypes as Potential Antihyperlipidemics in Irradiated Rats

Abstract

TQ derivatives (4-7), could be considered as promising agents in pathologies implicating impaired lipid metabolism, preclinical evaluation is warranted. [Formula: see text].

Pterostilbene Inhibits Dyslipidemia-Induced Activation of Progenitor Adipose Gene Under High-Fat Diet and Radiation Stressor

“…These results are consistent with those in previous studies of irradiation consequences. 11 Afonso et al 48 found that the reduction in LCAT activity led to the free accumulation of cholesterol and excess plasma lipoprotein as LCAT is the essential enzyme for esterification and trans-esterification in the cholesterol process. It has been confirmed that PS therapy normalizes to a large extent the pathological changes in tissues of dyslipidemic rats.…”

“…The second is acyl-CoA cholesterol acyltransferase (ACAT) and lecithin cholesterol acyltransferase (LCAT), and, thirdly, cholesterol 7-hydroxylase, which is the rate-limiting enzyme in cholesterol catabolism to bile acid low-density lipoproteins (LDL) receptor, high-density lipoproteins (HDL) receptor, and scavenger receptor class B type 1 (SRB-1). 11,12 In correlation with the above, Meneses et al 13 stated that PON-1/ ARE-1 possesses antioxidant properties and is closely associated with HDLs, which detoxify lipid peroxides and protect LDLs from oxidation. Besides, Phua et al 14 noted that peroxisome proliferator-activated receptor (PPAR) controls adipocyte differentiation, glucose metabolism, and lipid homeostasis.…”

Poly(quinone-thiourea) with Improved Auxiliary Coordination Zn2+ Insertion/Extraction Positive Performance for Aqueous Zinc Ion Battery Cathodes

“…PQTU was prepared by a one-pot method with benzoquinone and thiourea as precursors. − Benzoquinone (324 mg, 3 mmol) and thiourea (76 mg, 1 mmol) were added to 20 mL of ethanol and were heated to reflux for 9 h under an air atmosphere. After cooling to room temperature, the reaction mixture was filtered.…”

Thymoquinone in Cancers Therapy

“…Disease Models References sulfur-containing TQ-analogs radiation-induced dyslipidemia in rats [28] nitrogen-substituted TQ analogues human ovarian cancer cell lines [29] 3aminothymoquino ne antifungal effect against Candida albicans, Saccharomyces cerevisiae and Aspergillus brasiliensis [30] By studying TQ and human serum albumin (HSA) interactions, results showed that the association of TQ with HSA did not affect the secondary structure of HSA. Moreover, the HSA/TQ thermodynamic analysis reported that the binding process occurred spontaneously, and the hydrophobic interactions were the principal intermolecular forces that stabilize the complex [31].…”