We present the result of magnetic and thermoelectric investigations of the series of Ce3Cu3−xAuxSb4 compounds. The experimentally obtained data are discussed based on ab initio band structure calculations. It has been shown that structural disorder resulting from doping of Ce3Cu3Sb4 with Au induces a spin-glass-like behavior in the Ce3Cu3−xAuxSb4 series. All components x exhibit a negative temperature coefficient of the resistivity and metallic behavior of thermopower S(T) in the temperature region of T > 100 K. The maximal S value of 250 μV/K was measured for the pristine Ce3Au3Sb4 sample, while the highest figure of merit ZT = 0.06 was obtained for sample x = 1.5 at the highest measured temperature (T = 390 K).