Semiconducting polymer nanoparticles for NIR-II fluorescence imaging-guided photothermal/thermodynamic combination therapy

Wang, Wenqi; Zhang, Xi; Ni, Xiaoyue; Zhou, Wen; Xie, Chen; Huang, Wei; Fan, Quli

doi:10.1039/d1bm01646f

Cited by 32 publications

(17 citation statements)

References 36 publications

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“…Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has tremendous potential in the antifungal area, especially for drug-resistant strains as alternative antifungal strategies. − PDT is a minimally invasive approach that produces ROS and other molecules to damage target cells and hinder the formation of biofilms through the activation of the photosensitizer . PTT utilizes temperature increases to kill fungi through the absorbance of light by metal nanomaterials. , However, hyperthermia may induce thermal damage to surrounding tissues and result in irreversible visual impairment in the ophthalmic application; thus, mild-temperature PTT which causes less damage to normal tissues is more suitable. , Moreover, ethylenediaminetetraacetic acid (EDTA) is reported to block the construction of fungal cell walls and inhibit filamentation and biofilm formation, which play crucial roles in the protection and development of fungus. , Therefore, a multitarget synergistic treatment strategy might be further enhanced and overcome the challenge of antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis

Yang

Wang

et al. 2022

ACS Nano

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Fungal keratitis is one of the most common blindness-causing diseases, but clinical antifungal treatment remains a challenge. The fungal cell wall and biofilm matrix which severely confine the drug preparation are the critical obstructive factors to therapeutic effects. Herein, we report ethylenediaminetetraacetic acid (EDTA) modified AgCu2O nanoparticles (AgCuE NPs) to disrupt the cell wall and then eradicate C. albicans through the internal cascade synergistic effects of ion-released chemotherapy, chemodynamic therapy, photodynamic therapy, and mild photothermal therapy. AgCuE NPs exhibited excellent antifungal activity both in preventing biofilm formation and in destroying mature biofilms. Furthermore, AgCuE NP based gel formulations were topically applied to kill fungi, reduce inflammation, and promote wound healing, using optical coherence tomography and photoacoustic imaging to monitor nanogel retention and therapeutic effects on the infected murine cornea model. The AgCuE NP gel showed good biosafety and no obvious ophthalmic and systemic side effects. This study suggests that the AgCuE NP gel is an effective and safe antifungal strategy for fungal keratitis with a favorable prognosis and potential for clinical translation.

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Section: Introductionmentioning

confidence: 99%

Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis

Yang

Wang

et al. 2022

ACS Nano

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“…Some inhibitors or chemotherapy drugs were reported to suppress the HSP expression, by introducing them into PTT system, photothermal/chemo combination therapy can be achieved ( Gao et al, 2021 ). HSPs may also be damaged by alkyl radicals ( Wang et al, 2022 ). Thus, combining PTT with thermodynamic therapy can achieve synergistic therapeutic efficacy.…”

Section: Nir-ii Pa Imaging-guided Combination Therapymentioning

confidence: 99%

Recent advances in small molecule dye-based nanotheranostics for NIR-II photoacoustic imaging-guided cancer therapy

Zhou

Yin

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window has gained more and more attention in recent years and showed great potential in the field of bioimaging. Until now, numerous materials have been developed as contrast agents for NIR-II PA imaging. Among them, small molecule dyes hold unique advantages such as definite structures and capability of fast clearance from body. By virtue of these advantages, small molecule dyes-constructed nanoparticles have relatively small size and show promise in the clinical translation. Thus, in this minireview, we summarize recent advances in small molecule dyes-based nanotheranostics for NIR-II PA imaging and cancer therapy. Studies about NIR-II PA imaging-guided phototherapy are first introduced. Then, NIR-II PA imaging-guided phototherapy-based combination therapeutic systems are reviewed. Finally, the conclusion and perspectives of this field are summarized and discussed.

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“…In addition, compared with traditional visible-light imaging, nearinfrared imaging is less affected by biological matrix scattering and tissue autofluorescence, which gives it a higher signal-tonoise ratio and better spatial resolution. Therefore, near-infrared imaging is more suitable for in vivo imaging, and NIR AfPIs are also ideal for early diagnosis, surgery navigation and photothermal therapy of tumors (28)(29)(30). Near-infrared inhibitor probes mainly include three structures: inhibitors, linkers and near-infrared dyes.…”

Section: Near-infrared Afpismentioning

confidence: 99%

Affinity probes based on small-molecule inhibitors for tumor imaging

Wang

et al. 2022

Front. Oncol.

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Methods for molecular imaging of target areas, including optical imaging, radionuclide imaging, magnetic resonance imaging and other imaging technologies, are helpful for the early diagnosis and precise treatment of cancers. In addition to cancer management, small-molecule inhibitors are also used for developing cancer target probes since they act as the tight-binding ligands of overexpressed proteins in cancer cells. This review aims to summarize the structural designs of affinity probes based on small-molecule inhibitors from the aspects of the inhibitor, linker, dye and radionuclide, and discusses the influence of the modification of these structures on affinity and pharmacokinetics. We also present examples of inhibitor affinity probes in clinical applications, and these summaries will provide insights for future research and clinical translations.

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Semiconducting polymer nanoparticles for NIR-II fluorescence imaging-guided photothermal/thermodynamic combination therapy

Abstract: Photothermal therapy is a promising phototherapeutic modality which has been widely studied in the cancer therapy. However, because of the influence of heat shock protein (HSP), the therapeutic efficacy of...

Cited by 32 publications

References 36 publications

Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis

Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis

Recent advances in small molecule dye-based nanotheranostics for NIR-II photoacoustic imaging-guided cancer therapy

Affinity probes based on small-molecule inhibitors for tumor imaging

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