2015
DOI: 10.1016/j.jocn.2014.08.029
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Seminal fluid analysis and testicular volume in adults with epilepsy receiving valproate

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Cited by 31 publications
(22 citation statements)
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“…Consequently, adverse effects may result, such as seminal atrophy, histopathological alterations and secretion reduction (including biochemical parameters), as shown in this study. Our findings were in agreement with a previous study conducted in adult epileptic patients receiving VPA (Hamed et al, ). Seminal secretion contains low‐molecular weight compounds such as fructose and electrolytes, particularly chloride and bicarbonate‐rich fluid to promote sperm capacitation, increase stability of sperm chromatin and suppress immune activity in the female reproductive tract (Aumüller & Riva, ; Gonzales & Villena, ; Gustavo, ; Lazzarino et al, ; Levine, Rinaldo, & Schultz, ; Tajima, Okamura, & Sugita, ).…”
Section: Discussionsupporting
confidence: 94%
“…Consequently, adverse effects may result, such as seminal atrophy, histopathological alterations and secretion reduction (including biochemical parameters), as shown in this study. Our findings were in agreement with a previous study conducted in adult epileptic patients receiving VPA (Hamed et al, ). Seminal secretion contains low‐molecular weight compounds such as fructose and electrolytes, particularly chloride and bicarbonate‐rich fluid to promote sperm capacitation, increase stability of sperm chromatin and suppress immune activity in the female reproductive tract (Aumüller & Riva, ; Gonzales & Villena, ; Gustavo, ; Lazzarino et al, ; Levine, Rinaldo, & Schultz, ; Tajima, Okamura, & Sugita, ).…”
Section: Discussionsupporting
confidence: 94%
“…In the literature, there are studies to report dose-dependent changes in sperm parameters but these studies focus on the semen of the same patient in different VPA doses. 27,29 In accordance with these studies,…”
Section: Lmgsupporting
confidence: 81%
“…Then, ABP and testosterone are combined and carried in spermatogonia and spermatocytes, so that germ cells obtain stable, high concentrations of androgen, and effectively differentiate into mature sperm. Many studies have shown that epilepsy and a variety of AEDs can adversely affect the quality of semen, particularly older AEDs, most of which can affect the sex hormones and in turn have an impact on the occurrence and maturation of sperm . The epileptic abnormal discharge of brain neurons can also affect the function of the hypothalamic‐pituitary‐gonadal axis, indirectly affecting the quality of sperm.…”
Section: Discussionmentioning
confidence: 99%
“…Many studies have shown that epilepsy and a variety of AEDs can adversely affect the quality of semen, particularly older AEDs, most of which can affect the sex hormones and in turn have an impact on the occurrence and maturation of sperm. 19,20 The epileptic abnormal discharge of brain neurons can also affect the function of the hypothalamic-pituitary-gonadal axis, indirectly affecting the quality of sperm.…”
Section: Discussionmentioning
confidence: 99%