Seminal Fluid and Spermatozoon Zinc Levels and Their Relationship to Human Spermatozoon Motility

Janick, John; Zeitz, L.; Whitmore, Willet F.

doi:10.1016/s0015-0282(16)38465-5

Cited by 44 publications

(8 citation statements)

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“…The overall result is larger values of sperm motility, percentage of morphologically normal spermatozoa and HOST outcome. Although the attribution of the larger values of the percentage of morphologically normal spermatozoa, sperm motility parameters and HOST outcome to enhanced prostatic secretions is speculative, it is supported by reports showing that when ejaculates are grouped into classes according to semi-arbitrary definitions of fertilizability, the class with the highest fertilizability has a significantly higher zinc mass in the seminal plasma than the other classes (Janick et al, 1971). In addition, Sofikitis & Miyagawa (1993) have shown that qualitative and quantitative sperm motility, percentage of morphologically normal spermatozoa and outcome of the HOST are significantly larger in semen samples collected via intercourse than via masturbation, due to the larger sexual stimulation during production of the former samples.…”

Section: Discussionmentioning

confidence: 99%

Influence of sexual stimulation on sperm parameters in semen samples collected via masturbation from normozoospermic men or cryptozoospermic men participating in an assisted reproduction programme

Yamamoto

Sofikitis

Mio³

et al. 2009

Andrologia

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Key words. Cryptozoospermia-masturbation-semen-sexualstimulation-sperm function S u m m a r y . To evaluate the influence of sexual stimulation via sexually stimulating videotaped visual images (VIM) on sperm function, two semen samples were collected from each of 19 normozoospermic men via masturbation with VIM. Two additional samples were collected from each man via masturbation without VIM. The volume of seminal plasma, total sperm count, sperm motility, percentage of morphologically normal spermatozoa, outcome of hypo-osmotic swelling test and zona-free hamster oocyte sperm penetration assay, and markers of the secretory function of prostate were significantly larger in semen samples collected via masturbation with VIM than masturbation without VIM. The improved sperm parameters in the samples collected via masturbation with VIM may reflect an enhanced prostatic secretory function and increased loading of the vas deferens at that time. In a similar protocol, two semen samples were collected via masturbation with VIM from each of 22 non-obstructed azoospermic men. Semen samples from these men had been occasionally positive in the past for a very small number of spermatozoa (cryptozoospermic men). Two additional samples were collected from each cryptozoospermic man via masturbation without VIM. The volume of seminal plasma, total sperm count, sperm motility, and a marker of the secretory function of prostate were significantly larger in semen samples collected via masturbation with VIM. Fourteen out of the 22 men were negative for spermatozoa in both samples collected via mas-Correspondence: Nikolaos Sofikitis, fax: +81 859 348074.turbation without VIM. These men demonstrated spermatozoa in both samples collected via masturbation with VIM. Six men with immotile spermatozoa in both samples collected via masturbation without VIM exposed motile spermatozoa in both samples collected via masturbation with VIM. High sexual stimulation during masturbation with VIM results in recovery of spermatozoa of greater fertilizing potential both in normozoospermic and cryptozoospermic men. The appearance of spermatozoa after masturbation with VIM in the vast majority of cryptozoospermic men is of clinical significance in programmes applying intracytoplasmic sperm injections for the management of severe male infertility and obviates the need for testicular biopsy. U S .

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Section: Discussionmentioning

confidence: 99%

Influence of sexual stimulation on sperm parameters in semen samples collected via masturbation from normozoospermic men or cryptozoospermic men participating in an assisted reproduction programme

Yamamoto

Sofikitis

Mio³

et al. 2009

Andrologia

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“…In the central nervous system (CNS), such a double role seems to have been established [25]. A stabilizing effect in relation to sperm cell chromatin decondensation and sperm cell motility has also been shown [26,27]. AMG ZnS zinc is generally found in secretory vesicles in the pancreatic ␤ cells, in the submandibular salivatory glands of mice, and in synaptic vesicles of zinc-enriched neuron (ZEN) terminals of the CNS [25,28,29].…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural localization of zinc ions in the rat prostate: An autometallographic study

et al. 1997

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BACKGROUND The prostate contains high amounts of free zinc ions which are excreted into the seminal fluid. The extra‐ and intracellular distribution of zinc ions using the highly specific autometallographical (AMG) method is described. METHODS Prostates from sulfide‐perfused rats were excised, and the ZnS crystals were silver‐enhanced to sizes detectable by the electron and light microscope. RESULTS AMGZnS grains were found primarily in the acinic lumen of the lateral lobes. The dorsal lobe stained only faintly, while the ventral lobe was void of grains. At ultrastructural levels, the presence of zinc ions was confined to apical secretory vesicles and lysosome‐like structure of the epithelium of mainly the lateral lobes. CONCLUSIONS We suggest a constant secretion of zinc ions from the epithelial cells into both the acinar lumen and the intercellular canaliculi, and that the zinc enriched secretory cells in the prostate belong to a system of glandular cells that uses zinc ions to aggregate macromolecules to be excreted. Prostate 31:125–130, 1997. © 1997 Wiley‐Liss, Inc.

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“…A relationship between seminal fluid zinc or sperm cell zinc and sperm motility has been reported by several authors (White, 1955;Rosado et al, 1970;Eliasson & Lindholmer, 1971;Janick et al, 1971;Caldamore et al, 1979;Shoenfeld et al, 1979;Madding et al, 1986). Treatment with zinc-chelating agents is known to affect the motility of sperm cells (Saito et al, 1967a,b;Danscher & Rebbe, 1974).…”

Section: Introductionmentioning

confidence: 92%

Histochemical localization of zinc ions in the epididymis of the rat

et al. 1996

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In the present study, the autometallograpic zinc sulphide technique, an improved version of the original Timm sulphide-silver method, was used. This technique reveals a particular pool of ionic zinc that is chelatable by diethyldithiocarbamate. At the light microscopical level, no reaction for zinc was found in tissues of young prepubertal rats. In adult mating and non-mating rats low zinc staining was found in the head and intermediate epididymis whereas the tail of the epididymis demonstrated high levels of zinc ions. Sections from the epididymal tail revealed a 'compartmentalization', based on pronounced differences in staining intensity along the epididymal ducts. At higher magnification zinc ions were found in the apical part of the principal cell and in the lumen. At the ultrastructural level autometallographic grains were located in vesicles and in lysosome-like structures of the apical parts of the principal cells. The luminal grains were found either associated with sperm cells, with the surface of the large microvilli (stereocilia), or free in the seminal fluid. The variation in content of zinc ions in the epididymal epithelium and lumen suggests that zinc ions are secreted into the lumen from the epididymal tail and may somehow be involved in maturation of the sperm cells.

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Seminal Fluid and Spermatozoon Zinc Levels and Their Relationship to Human Spermatozoon Motility

Cited by 44 publications

References 10 publications

Influence of sexual stimulation on sperm parameters in semen samples collected via masturbation from normozoospermic men or cryptozoospermic men participating in an assisted reproduction programme

Influence of sexual stimulation on sperm parameters in semen samples collected via masturbation from normozoospermic men or cryptozoospermic men participating in an assisted reproduction programme

Ultrastructural localization of zinc ions in the rat prostate: An autometallographic study

Histochemical localization of zinc ions in the epididymis of the rat

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