Seminal Fluid and the Generation of Regulatory T Cells for Embryo Implantation

Robertson, Sarah A.; Prins, Jelmer R.; Sharkey, David J.; Moldenhauer, Lachlan M.

doi:10.1111/aji.12107

Cited by 156 publications

(149 citation statements)

References 118 publications

(184 reference statements)

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“…Treg cells are essential for suppressing destructive alloantigenic immunity during pregnancy (Zenclussen 2006;Munoz-Suano et al 2011;Robertson et al 2013). These cells are peripherally induced, as their differentiation depends on both paternal antigens and the conserved noncoding sequence-1 (CNS1) enhancer element that contains a Smad-binding site at the Foxp3 locus (Zheng et al 2010;Rowe et al 2012;Samstein et al 2012).…”

Section: Fetal -Maternal Tolerancementioning

confidence: 99%

“…Semen provides both male alloantigens and immunomodulatory factors that sufficiently exert biological influences in the FRT, such as activating cytokine gene expression and eliciting changes in the abundance and behavior of infiltrating leukocyte populations. These responses promote tolerance and receptivity for embryo implantation (Robertson 2005;Robertson et al 2013). The mechanisms underlying immunological suppression by semen are not clearly defined but appear related, at least in part, to extremely high concentrations of TGF-b and prostaglandin (PG)E 2 (Robertson et al 2002(Robertson et al , 2009b.…”

Section: Fetal -Maternal Tolerancementioning

confidence: 99%

“…Exogenous TGF-b delivered at conception also boosts the numbers of vaginal Treg cells and helps reduce fetal loss in the CBA/J Â DBA/2J spontaneous abortion model (Clark et al 2008). Thus, seminal TGF-b has been implicated as a key factor in initiating the remodeling events and immunological changes that occur in the uterus during the preimplantation period of pregnancy (Robertson et al 2002(Robertson et al , 2013.…”

Section: Fetal -Maternal Tolerancementioning

confidence: 99%

See 2 more Smart Citations

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

Sanjabi

2017

Cold Spring Harb Perspect Biol

480

306

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Transforming growth factor b (TGF-b) is a pleiotropic cytokine involved in both suppressive and inflammatory immune responses. After 30 years of intense study, we have only begun to elucidate how TGF-b alters immunity under various conditions. Under steady-state conditions, TGF-b regulates thymic T-cell selection and maintains homeostasis of the naïve T-cell pool. TGF-b inhibits cytotoxic T lymphocyte (CTL), Th1-, and Th2-cell differentiation while promoting peripheral ( p)Treg-, Th17-, Th9-, and Tfh-cell generation, and T-cell tissue residence in response to immune challenges. Similarly, TGF-b controls the proliferation, survival, activation, and differentiation of B cells, as well as the development and functions of innate cells, including natural killer (NK) cells, macrophages, dendritic cells, and granulocytes. Collectively, TGF-b plays a pivotal role in maintaining peripheral tolerance against self-and innocuous antigens, such as food, commensal bacteria, and fetal alloantigens, and in controlling immune responses to pathogens.

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Section: Fetal -Maternal Tolerancementioning

confidence: 99%

Section: Fetal -Maternal Tolerancementioning

confidence: 99%

Section: Fetal -Maternal Tolerancementioning

confidence: 99%

See 1 more Smart Citation

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

Sanjabi

2017

Cold Spring Harb Perspect Biol

480

306

View full text Add to dashboard Cite

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“…This inflammatory response to semen and the associated change in the cytokine environment has been hypothesised to mediate several downstream effects in the female reproductive tract [9]. More recently these studies have been recapitulated in the human, particularly the cervix following intercourse [10][11][12]. Recently we have reported that pregnancies initiated in the absence of seminal plasma in mice give rise to progeny with altered metabolic profiles, obesity and hypertension due in part to perturbations in the peri-conceptional environment and oviduct expression of embryotrophic cytokines [13].…”

Section: Introductionmentioning

confidence: 99%

Seminal fluid and reproduction: much more than previously thought

Bromfield

2014

J Assist Reprod Genet

127

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The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to uterine seminal plasma exposure on pregnancy and offspring health is becoming more clearly understood. The cellular and molecular environment of the uterus during the pre-and peri-implantation period of early pregnancy is critical for implantation success and optimal foetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health and viability, but can also drive adverse health outcomes in the offspring after birth, particularly the development of metabolic disorders such as obesity, hypertension and insulin resistance. It is now reported that an absence of seminal plasma at conception in mice promotes increased fat accumulation, altered metabolism and hypertension in offspring. The evidence reviewed here demonstrates that seminal plasma is not simply a transport medium for sperm, but acts also as a key regulator of the female tract environment providing optimal support for the developing embryo and benefiting future health of offspring.

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“…Исходя из этого, HLA-G является ключевой молекулой, обеспечивающей иммунные взаимодействия ма-точного микроокружения с аллогенными HLA эмбриона, а нарушения ее экспрессии будут приводить к индукции тератогенеза, связанно-го с фоновыми ксенобиотическими нагрузками. Исследователями показана связь материнского полиморфизма HLA-G 3'UTR 14-bp ins/del с вер-тикальной передачей от матери к эмбриону/плоду резидентных вирусов [14]. Ранняя активация у ма-тери и эмбриона геномов вирусов может способ-ствовать манифестации тератогенеза [15,16,17].…”

Section: распределение аллелей и генотипов Hla-g 3'utr у женщинunclassified

DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS

et al. 2017

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Адрес для переписки:Цепокина Анна Викторовна ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» 652002, Россия, г. Кемерово, Сосновый бульвар, 6. Тел.: 8 (3842) 64-46-50. E-mail: cepoav1991@gmail.com Diseases 650002, Russian Federation, Kemerovo, Sosnoviy blvd, 6. Phone: 7 (3842) 64-46-50. E-mail: cepoav1991@gmail.com иммунология, 2017. Т. 19, № 6. С. 763-770. doi: 10.15789/1563-0625-2017-6-763-770 © Шабалдин А.В. и соавт., 2017 For citation: A.V. Shabaldin, A.V. Tsepokina, S.A. Shmulevich, A.V. Ponasenko, P.M. Kryukov, E.V. Shabaldina /Meditsinskaya Immunologiya, 2017, Vol. 19, no. 6, pp. 763-770. doi: 10.15789/1563-0625-2017-6-763-770 DOI: 10.15789/1563-0625-2017 Резюме. Врожденные пороки сердца являются доминирующей патологией среди всех врожденных пороков плода и новорожденного. Нарушения иммунных взаимодействий в системе «мать -эмбри-он» могут быть следствием тератогенеза. HLA-G является основной молекулой, посредством которой формируется толерантность материнского иммунного микроокружения к полуаллогенному эмбрио-ну. Полиморфный вариант гена HLA-G 3'UTR 14-bp ins/del влияет на устойчивость и экспрессию ма-тричной РНК и тем самым на эффективность блокирования иммунного отторжения полуаллогенно-го эмбриона. Цель исследования была связана с поиском ассоциативных связей между носительством женщинами одного из полиморфных вариантов гена HLA-G 3'UTR 14-bp ins/del с репродуктивными потерями и рождением детей с врожденными пороками сердца. Address for correspondence: Tsepokina Anna V. Research Institute for Complex Issues of CardiovascularОбследовано 103 женщины, имеющие детей с врожденными пороками сердца, 21 женщина с ре-продуктивными потерями до 9 недель беременности и 101 женщина, имеющая двух и более здоровых детей.Выявлено, что маркером ранних репродуктивных потерь у женщин являлся минорный гомозигот-ный генотип HLA-G 3'UTR 14-bp ins/14-bp ins (OR = 5,25; 95%CI = 1,31-21,11) и аллель HLA-G 3'UTR 14-bp ins (OR = 2,34; 95%CI = 1,13-4,84). При носительстве женщиной гетерозиготного вариантного генотипа 14-bp ins/14-bp del HLA-G 3'UTR значимых ассоциаций с рождением детей с ВПС не опре-делено. Abstract. HLA-G is the main molecule through which provides tolerance of maternal immune microenvironment to the semi-allogeneic embryo. Polymorphic variant of 14-bp ins/del in the HLA-G 3'UTR gene affects stability and expression of specific mRNA and, thereby, efficiency of immune rejection blockade of the semi-allogeneic embryo. Immune interactions in the "mother -fetus"system can cause teratogenic effects. Congenital heart defects are the dominant pathology among congenital malformations of the fetus and newborns. The aim of the study was to search possible associations between polymorphic 14-bp ins/del variants of maternal HLA-G 3'UTR gene, and reproductive losses or congenital heart defects in their children. Subjects and Methods. We have examined 103 women who had children with congenital heart defects, 21 women with reproductive losses at up...

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Seminal Fluid and the Generation of Regulatory T Cells for Embryo Implantation

Abstract: CitationRobertson SA, Prins JR, Sharkey DJ, Moldenhauer LM. Seminal fluid and the generation of regulatory T cells for embryo implantation. Am J

Cited by 156 publications

References 118 publications

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

Seminal fluid and reproduction: much more than previously thought

DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS

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