Seminal plasma anti-M�llerian hormone level correlates with semen parameters but does not predict success of testicular sperm extraction (TESE)

Abstract

Seminal plasma AMH is an absolute testicular marker being absent in all OA cases. However, seminal AMH has a poor predictability for successful testicular sperm retrieval in NOA cases.

Seminal plasma concentrations of Anti‐Müllerian hormone and inhibin B predict motile sperm recovery from cryopreserved semen in asthenozoospermic men: a prospective cohort study

“…Coherently with this hypothesis, oligozoospermia was not associated with significant alterations in seminal concentrations of either AMH or inhibin B in the present study, while previous studies have found lower AMH levels (Fujisawa et al, 2002) or non-significant changes (Duvilla et al, 2008) in oligozoospermic men. In addition, these hormones are detectable in the semen of a significant proportion of men with non-obstructive azoospermia, including those in whom no spermatozoa could be retrieved from testicular biopsies (Mostafa et al, 2007;Mitchell et al, 2010).…”

“…Given that AMH and inhibin B reflect Sertoli cell function and appear to be related to both the amount and the quality of spermatogenesis (Fujisawa et al, 2002;Mostafa et al, 2007;Duvilla et al, 2008), we hypothesized that measuring their concentrations in the seminal plasma might help to predict the recovery of motile spermatozoa after cryopreservation.…”

The Sertoli cell: Novel clinical potentiality

“…Similarly, seminal AMH concentrations have been found to be significantly lower 11,[20][21][22][23] or equal 15 in subfertile men compared with fertile controls. In order to further elucidate the role of inhibin B and AMH in male subfertility we designed a prospective control-matched study with the aim of determining serum inhibin B and AMH concentrations in men with different causes of subfertility.…”

Seminal plasma levels of anti-Müllerian hormone and inhibin B are not predictive of testicular sperm retrieval in nonobstructive azoospermia: a study of 139 men

“…However, the predictive value of seminal plasma levels of AMH or inhibin B as predictors of the presence of testicular spermatozoa is still subject to debate. Seminal AMH was poorly predictive of successful TESE in NOA in one study (18), but was an individual predictive marker in another, in which testicular spermatozoa appeared to be associated with detectable AMH levels (13). Likewise, seminal inhibin B was variously a strong predictor of the TESE outcome (16) or had no relation to successful or unsuccessful TESE in azoospermic samples (17).…”