Seminars in Thrombosis, Thrombolysis, and Vascular Biology

Rc, Becker

doi:10.1159/000174889

Cited by 6 publications

(7 citation statements)

References 30 publications

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“…There is a small literature strongly suggesting that several factors related to blood viscosity are adversely affected by hypohydration (16)(17)(18)(19)(20)(21)(35)(36)(37)(38)(39) and that these rheologic factors predict the risk of coronary heart disease (4,6,8,9). Whole blood viscosity is determined mainly by hematocrit and fibrinogen levels, both of which have frequently been associated with coronary heart disease events (1)(2)(3)(4)(5)(6)(7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

“…In some reports, the magnitudes of their effects are comparable with those of smoking, diastolic blood pressure, and low density serum cholesterol (2,4,6). These hemorheologic factors are found to be elevated years before manifestation of acute ischemic events (4) and are implicated in the early stages (6), acceleration (8), and extent (9) of atherosclerosis, as well as prognosis in patients with arteriosclerotic disease (5,10). They are also associated with hypertension (11) and intermittent claudication (12).…”

mentioning

confidence: 89%

“…Whole blood viscosity (1)(2)(3), plasma viscosity (4), fibrinogen (1)(2)(3)(4)(5), and hematocrit (2-6) levels are positively correlated with coronary heart disease. Even in the high "normal" range, they have been considered independent risk factors (2,(4)(5)(6)(7). In some reports, the magnitudes of their effects are comparable with those of smoking, diastolic blood pressure, and low density serum cholesterol (2,4,6).…”

mentioning

confidence: 99%

“…They are also associated with hypertension (11) and intermittent claudication (12). Additionally, a higher hematocrit level has been associated with tachycardia (13), infarct size (14), reduced oxygen transport (15), and reduced myocardial perfusion (5).…”

mentioning

confidence: 99%

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Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study

Chan

Knutsen²,

Blix³

et al. 2002

American Journal of Epidemiology

146

123

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Whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen are considered independent risk factors for coronary heart disease and can be elevated by dehydration. The associations between fatal coronary heart disease and intake of water and fluids other than water were examined among the 8,280 male and 12,017 female participants aged 38-100 years who were without heart disease, stroke, or diabetes at baseline in 1976 in the Adventist Health Study, a prospective cohort study. A total of 246 fatal coronary heart disease events occurred during the 6-year follow-up. High daily intakes of water (five or more glasses) compared with low (two or fewer glasses) were associated with a relative risk in men of 0.46 (95% confidence interval (CI): 0.28, 0.75; p trend = 0.001) and, in women, of 0.59 (95% CI: 0.36, 0.97). A high versus low intake of fluids other than water was associated with a relative risk of 2.47 (95% CI: 1.04, 5.88) in women and of 1.46 (95% CI: 0.7, 3.03) in men. All associations remained virtually unchanged in multivariate analysis adjusting for age, smoking, hypertension, body mass index, education, and (in women only) hormone replacement therapy. Fluid intake as a putative coronary heart disease risk factor may deserve further consideration in other populations or using other study designs.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 89%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study

Chan

Knutsen²,

Blix³

et al. 2002

American Journal of Epidemiology

146

123

View full text Add to dashboard Cite

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“…A large number of studies have demonstrated that vascular cells play a critical role in maintaining the normal functions of blood vessels. 28,29 According to the basic principle of tissue engineering, vascular cells are the initial candidates for vascular regeneration.…”

Section: Terminally Differentiated Vascular Cellsmentioning

confidence: 99%

Cell‐based strategies for vascular regeneration

Zou

Fan

Fartash

et al. 2016

J Biomedical Materials Res

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Vascular regeneration is known to play an essential role in the repair of injured tissues mainly through accelerating the repair of vascular injury caused by vascular diseases, as well as the recovery of ischemic tissues. However, the clinical vascular regeneration is still challenging. Cell-based therapy is thought to be a promising strategy for vascular regeneration, since various cells have been identified to exert important influences on the process of vascular regeneration such as the enhanced endothelium formation on the surface of vascular grafts, and the induction of vessel-like network formation in the ischemic tissues. Here are a vast number of diverse cell-based strategies that have been extensively studied in vascular regeneration. These strategies can be further classified into three main categories, including cell transplantation, construction of tissue-engineered grafts, and surface modification of scaffolds. Cells used in these strategies mainly refer to terminally differentiated vascular cells, pluripotent stem cells, multipotent stem cells, and unipotent stem cells. The aim of this review is to summarize the reported research advances on the application of various cells for vascular regeneration, yielding insights into future clinical treatment for injured tissue/organ.

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Hemodynamic characteristics of the intrahepatic portal vascular bed over an extended flow range: A study in the isolated perfused rat liver

Grossman

Bhathal

1995

Hepatology

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The relationship between the perfusion pressure (P) and resistance (R) of the intrahepatic portal vascular bed was determined in isolated rat liver preparations perfused with fresh, heparinized rat blood (hematocrit 30%), with rat blood containing a vasodilator agent (sodium nitroprusside, 1 X 10(-3) mol/L), or with 2.5% bovine serum albumin in Krebs-Henseleit buffer (BSA-KH). Pressure-flow curves were constructed over an extended range of portal venous inflow (0 to 70 mL.min-1, corresponding to a flow rate per gram liver wet weight, Q, of approximately 0 to 7 mL.min-1.g-1). Subsequent analysis showed that two mathematical expressions adequately described the data over the full range of flow. Thus, the pressure-flow curve could be represented by (a) the sum of a linear plus a hyperbolic function, i.e., P = Q.R' + Pmax.Q/(Q + Km), where R', Pmax, and Km are constants, or (b) by the simple equation G = C.P, where G is the conductance (Q/P), and C is a conductivity constant. The values of R', Pmax, Km, and C were significantly different under each of the circumstances investigated, but the form of the curve was not altered. Hence, it is proposed that these parameters can be used to describe the fundamental hemodynamic properties of the portal vascular bed of the isolated rat liver. The results are discussed in terms of the microvascular recruitment and distensible resistance vessel models of the hepatic microcirculation.

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Seminars in Thrombosis, Thrombolysis, and Vascular Biology

Cited by 6 publications

References 30 publications

Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study

Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study

Cell‐based strategies for vascular regeneration

Hemodynamic characteristics of the intrahepatic portal vascular bed over an extended flow range: A study in the isolated perfused rat liver

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