1986
DOI: 10.1099/0022-1317-67-2-391
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Semipermissive Replication of Adenovirus 5 in Rat Brain Cells and Evidence for an Induction of Cellular DNA Replication in vivo

Abstract: 391 SUMMARYHuman adenovirus type 5 is shown to cause a limited infection of the cells lining the ventricles of 2-to 3-week-old newborn rats. By the distribution of fluorescent antibodylabelled cells the infection appears to be confined to the ependymal cells. In these same (ependymal) cells autoradiographic labelling of [3 H]thymidine-pulsed brains indicates that viral and possibly cellular DNA synthesis is occurring. Studies with the mutants dl 312 and dl 313 indicate that some cellular DNA synthesis is indee… Show more

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