Semiquantitative Analysis of Biological Materials by Inductively Coupled Plasma–Mass Spectrometry

Amarasiriwardena, Dulasiri; Durrant, Steven F.; Lásztity, Alexandra; Kvska, Antoaneta; Argentine, Mark D.; Barnes, Ramon M.

doi:10.1006/mchj.1997.1454

Cited by 27 publications

(23 citation statements)

References 17 publications

(22 reference statements)

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“…Their determinations have an accuracy of only 630-50% (Amarasiriwardena et al, 1997) due to the lack of appropriate elemental standards for quantitative analysis. Data are measured as intensities (counts per second) as opposed to concentrations (ppm).…”

Section: La-icp-ms Analyses Of Biological Tissuesmentioning

confidence: 99%

Variation in elemental intensities among teeth and between pre‐ and postnatal regions of enamel

Dolphin

Goodman

Amarasiriwardena

2005

American J Phys Anthropol

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Microspatial analyses of the trace element composition of dental enamel are made possible using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). Fine spatial resolution, multielement capabilities, and minimal sample destruction make this technique particularly well-suited for documenting the distribution of elements in sequentially calcifying layers of enamel. Because deciduous enamel forms from week 13 in utero up to 9 months postnatally (thereafter essentially becoming inert), the application of LA-ICP-MS allows for the retrospective measurement of prenatal and early postnatal trace-element uptake during a critical period of child development. In this study, we compared intra- and intertooth intensities of 25Mg, 57Fe, 66Zn, 68Zn, 88Sr, 138Ba, and 208Pb via LA-ICP-MS of 38 exfoliated deciduous incisors and canines donated by 36 participants in the Solís Valley Mexico Nutrition Collaborative Research Support Program (NCRSP). Pre- and postnatal comparisons within teeth showed significant increases (P < 0.001) and greater variation in the abundance of all isotopes in postnatal enamel, with the exception of a decrease in 25Mg (P < 0.001) and constant values for 88Sr (P = 0.681). Conversely, comparisons by tooth type and mouth quadrant revealed few significant differences between teeth of the same individual. We argue that more variation in the trace element composition of teeth occurs across developmental areas within a tooth than among different teeth of the same person. This study further demonstrates that sequentially calcifying areas of enamel have different chemical concentrations. The results support the use of microspatial analyses of enamel for understanding changes in nutrition, pollution, and residence.

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Section: La-icp-ms Analyses Of Biological Tissuesmentioning

confidence: 99%

Variation in elemental intensities among teeth and between pre‐ and postnatal regions of enamel

Dolphin

Goodman

Amarasiriwardena

2005

American J Phys Anthropol

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“…This strategy is time consuming and it is not easy to have a complete set of the multi-element standards required for the calibration. A third option, the semi-quantitative mode of analysis, is a versatile application of ICP-MS that it is claimed to allow the determination of about 80 elements with errors <20 % for most elements (Laborda et al 2001;Soldevilla et al 1998;Amarasiriwardena et al 1997). This methodology has been successively applied to samples of different nature and origin, like biological (Amarasiriwardena et al 1997;Krushevska et al 1996;Alonso et al 1997), environmental (Alonso et al 1997), industrial (Hu et al 1997), food (Castillo et al 1999;Jakubowski et al 1999;Castineira et al 2001) and plastics (Fordham et al 1995) samples.…”

Section: Introductionmentioning

confidence: 99%

“…TotalQuant II from Perkin-Elmer) has facilitated the rapid acquisition of analytical data by correcting automatically isobaric and molecular interferences as well as relative isotope abundances. This type of analysis is based on a pre-calibrated internal response (defined as ions per second per concentration unit) for all elements, which can be update with a single-point calibration (Amarasiriwardena et al 1997) In present study we have compared inductively coupled plasma mass spectrometry (ICP-MS), a latest technique can detect the elements at ppt level with atomic absorption spectrometry (AAS) for Fe and Zn determination in six different food material like Banana, Papaya, Rice, Finger millet, Soybean and Urdbean.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy of two standard methods for determination of iron and zinc in fruits, pulses and cereals

et al. 2013

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Micronutrients are essential elements needed in small amounts for adequate human nutrition and include the elements iron and zinc. Both of these minerals are essential to human well-being and an adequate supply of iron and zinc help to prevent iron deficiency anaemia and zinc deficiency, two prevalent health concerns of the developing world. The levels of zinc and, iron were measured in the Banana, Papaya, Rice, Finger millet, Soybean and Urdbean. Standard Atomic absorption spectroscopy (AAS) method was also applied to all the samples for zinc and iron analysis and compared with inductively coupled plasma mass spectroscopy (ICP-MS). It was observed that there was no matrix interference affecting the determination of both elements interested in all the samples analyzed. Average concentration relative standard deviation and standard deviation were used for the statistical evaluation of the results for both elements. Correlation coefficient was used as statistical model to compare both the techniques.

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“…2 The calibration procedure is usually also combined with internal standards to correct for plasma instability and instrumental drift. 3 Analytical results obtained with semi-quantitative ICP-MS based methods have critically been evaluated in several studies with different certified reference materials such as bovine liver, [4][5][6] horse kidney, 6 mussel tissue, 5,7 oyster tissue, 4 non-fat milk powder, 5 tomato leaves, 4,5 citrus leaves, 6 spinach, 7 pine needless, 4,5 sea lettuce, 8 hay, 6 wheat flour, 5 total diets 5 and different water types. 3,4,[8][9][10][11] These studies have all shown that despite relying on a rather simple calibration procedure and a fast data acquisition, the accuracy of semi-quantitative analysis is generally >70% of the true value for many elements.…”

Section: Introductionmentioning

confidence: 99%

Multi-elemental fingerprinting of plant tissue by semi-quantitative ICP-MS and chemometrics

Laursen

Hansen

Persson

et al. 2009

J. Anal. At. Spectrom.

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The multi-elemental capacity of Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) is rarely fully utilized in traditional full-quantitative analysis. The main obstacles are limited availability of multi-elemental standards and the need for time-consuming external calibrations. In this study, a novel semi-quantitative quadrupole ICP-MS based method for multi-elemental fingerprinting of plant tissue was developed as a high-throughput alternative to full-quantitative analysis. The main analytical objectives were low data acquisition time (<60 seconds), detailed coverage of the atomic mass range from 7 Li to 238 U and discrimination power similar to full-quantitative analysis based on chemometric data analysis. The method was tested on grains of different rice (Oryza sativa) genotypes. The semiquantitative rice fingerprints consisted of 30 elements based on the limit of detections as inclusion criteria. Fourteen of these were determined with an accuracy >70%. In conjunction with chemometrics, the discrimination power of the semi-quantitative results was better than that of full-quantitative analysis. The superior discrimination power of semi-quantitative analysis was maintained, even when it was combined with a high-throughput digestion procedure, which represented a 5 fold reduction in analytical labour consumption. Thus, the large amount of elemental information obtained using semiquantitative ICP-MS fully outweighed the lack of accuracy compared to full-quantitative analysis. For the first time it is demonstrated that semi-quantitative ICP-MS in combination with chemometrics provides a fast and powerful alternative to traditional full-quantitative ICP-MS. The method developed here constitutes a promising novel analytical tool, which has the potential to mature into a routine procedure for testing e.g. the authenticity and adulteration of food products.

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Semiquantitative Analysis of Biological Materials by Inductively Coupled Plasma–Mass Spectrometry

Cited by 27 publications

References 17 publications

Variation in elemental intensities among teeth and between pre‐ and postnatal regions of enamel

Variation in elemental intensities among teeth and between pre‐ and postnatal regions of enamel

Comparative efficacy of two standard methods for determination of iron and zinc in fruits, pulses and cereals

Multi-elemental fingerprinting of plant tissue by semi-quantitative ICP-MS and chemometrics

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