Semiquantitative analysis of histologic criteria in thin malignant melanomas

Stolz, Wilhelm; Schmoeckel, Christian; Welkovich, Bruce; Braun‐Falco, Otto

doi:10.1016/s0190-9622(89)70143-2

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…In melanomas, single melanocytes were mostly irregularly disposed, not equidistant from one another, in the basal layer as well as in the other epidermal layers, in effaced rete ridges; in naevi, single melanocytes were observed mostly in lentiginous pattern with cells as junctional single units in an elongated rete ridges [2]. Some parameters investigated showed a sensitivity higher than that found in a previous study (cytological atypia = 84%, dermal lymphocytic infiltrate = 56%, suprabasal melanocytes = 80%, asymmetry = 81%, mitoses = 33% and poor circumscription = 49% [22]), in which, however, melanomas were of lower thickness (r1.5 mm) and criteria used more restrictive than those adopted in this study. Conversely, suprabasal melanocytes showed a sensitivity (83% in the group of 72 melanomas and 95% in the subgroup of 20 melanomas r2 mm) lower or slightly lower than that obtained in another study (96%) [23].…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and specificity of histological criteria in the diagnosis of conventional cutaneous melanoma

Urso

Saieva²,

Borgognoni³

et al. 2008

Melanoma Research

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The efficacy of the histological criteria currently used in the diagnosis of melanoma is still to be defined. We performed a quantitative analysis of 72 conventional (non-Spitzoid, nondesmoplastic) melanomas and 73 conventional melanocytic naevi, used as controls, for 13 histological diagnostic parameters (dimension >6 mm, asymmetry, poor circumscription, irregular and confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, cytological atypia, mitoses, necrosis and dermal lymphocytic infiltrate). Differences in the distribution of selected parameters between the two groups were investigated by Fisher's exact test; for each parameter sensitivity and specificity were calculated. Results showed that all parameters, except poor circumscription, seemed to be significantly associated with melanoma (P<0.05). Cytological atypia, dermal lymphocytic infiltrate, asymmetry, dimension >6 mm and absence of maturation showed a high sensitivity (>90%); absence of maturation, mitoses, necrosis, asymmetrical melanin, suprabasal melanocytes and melanin in deep cells showed a high specificity (>90%); irregular-confluent nests and single melanocytes predominating were poorly sensitive and poorly specific. In melanomas < or =2 mm, two additional parameters were sensitive (> or =90%): suprabasal melanocytes and single melanocytes predominating. We conclude that not all parameters showed to have the same diagnostic value. Absence of maturation and, limited to melanomas < or =2 mm, suprabasal melanocytes were the most discriminating (sensitive and specific) histological features. Cytological atypia, dimension >6 mm, suprabasal melanocytes and mitoses were additional reliable diagnostic features, showing a relatively high sensitivity and a relatively high specificity. Other useful features were dermal lymphocytic infiltrate and asymmetry (sensitive) and necrosis, asymmetrical melanin and melanin in deep cells (specific).

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Section: Discussionmentioning

confidence: 99%

Sensitivity and specificity of histological criteria in the diagnosis of conventional cutaneous melanoma

Urso

Saieva²,

Borgognoni³

et al. 2008

Melanoma Research

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“…He cannot use these features to make an algorithmic approach to the diagnosis of melanoma. Stolz and co‐workers illustrated this problem in an article in 1989 in which they examined 150 cases of melanoma using the seven attributes they considered most important diagnostically: 2…”

Section: Pathologymentioning

confidence: 99%

Pathology Correlations with Optical Biopsy Techniques^a

Flotte

1998

Annals of the New York Academy of Sciences

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Traditional surgical pathology predicts the future course of a patient's disease based on subjective comparison of the biopsy with the outcome of similar biopsies that have been seen previously. Optical techniques are being designed to aid the clinician in evaluating the patients' tissue in vivo. These technologies assess the disease process itself, associated structural alterations or do not have a known physical basis. These techniques will have an almost immediate application in directing the location to biopsy. The true optical biopsy where a definitive diagnosis is made by in vivo optical technology is a laudable goal, but only a few such applications are likely to become available in the near future. In addition to these approaches, the movement towards telemedicine is going to increase the demand for this type of technology for remote monitoring at home as well as in hospital settings.

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“…Πολυπύρηνα μελανοκύτταρα με έντονες δενδριτικές προεκτάσεις ('starburst giant cells') ανευρίσκονται συχνά στη βασική στιβάδα[142,143]. Σε κάποιες περιπτώσεις, ειδικά σε μελανώματα που εμφανίζονται σε άτομα μεγαλύτερης ηλικίας, στο άνω χόριο ανευρίσκεται μετρίου εως μεγάλου βαθμού ηλιακή ελάστωση και υπάρχουν μακροφάγα που περιέχουν χρωστική με μικρές συναθροίσεις λεμφοκυττάρων [146]. Μια σπάνια ποικιλία του μελανώματος, συνήθως του επιπολής επεκτεινόμενου, είναι το μυρμηκιώδες μελάνωμα[147].…”

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Μικροαγγειακή Πυκνότητα Και Αγγειογένεση Σε Συγγενείς, Κυανούς Σπίλους Και Επίκτητους Σπιλοκυτταρικούς Σπίλους

Ιωαννίδης¹

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Semiquantitative analysis of histologic criteria in thin malignant melanomas

Cited by 8 publications

References 27 publications

Sensitivity and specificity of histological criteria in the diagnosis of conventional cutaneous melanoma

Sensitivity and specificity of histological criteria in the diagnosis of conventional cutaneous melanoma

Pathology Correlations with Optical Biopsy Techniques^a

Μικροαγγειακή Πυκνότητα Και Αγγειογένεση Σε Συγγενείς, Κυανούς Σπίλους Και Επίκτητους Σπιλοκυτταρικούς Σπίλους

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Semiquantitative analysis of histologic criteria in thin malignant melanomas

Cited by 8 publications

References 27 publications

Sensitivity and specificity of histological criteria in the diagnosis of conventional cutaneous melanoma

Sensitivity and specificity of histological criteria in the diagnosis of conventional cutaneous melanoma

Pathology Correlations with Optical Biopsy Techniquesa

Μικροαγγειακή Πυκνότητα Και Αγγειογένεση Σε Συγγενείς, Κυανούς Σπίλους Και Επίκτητους Σπιλοκυτταρικούς Σπίλους

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Pathology Correlations with Optical Biopsy Techniques^a