Semiquantitative Chemical Analysis of Asbestos Fibers and Clay Minerals with an Analytical Electron Microscope

Hayashi, Hisato; Aita, Saburo; Suzuki, Mikio

doi:10.1346/ccmn.1978.0260301

Cited by 14 publications

(2 citation statements)

References 14 publications

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“…Optimally, identification of mineral species should be made on the basis of crystal structure and chemical composition. Therefore, 24 particles were examined structurally by means of SAED and then analyzed chemically using the procedure for semiquantitative analysis as described by Hayashi et al [1978]. Ten of 24 particles showed a large silicon peak with other small peaks and were identified as silicon carbide.…”

Section: Chemical Analysis Of Individual Particles By Analytical Elecmentioning

confidence: 99%

Silicon Carbide in Lung Tissue of a Worker in the Abrasive Industry

Hayashi

Kajita

1988

American J Industrial Med

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Lung tissue of a worker in an abrasive manufacturing plant, whose duration of dust exposure was about 10 years, was analyzed by means of bulk analysis and in situ analytical electron microanalysis. The content of the total dust in the lung was 120 mg/g of the dried lung tissue. This value is close to the average concentration of the total dust in the lungs of coal miners with massive fibrosis. The lung dust composition in this case was approximately 43% silicon carbide, 24% aluminium oxide, 2.3% cristobalite, 2.0% quartz, and trace of talc and feldspar. Silicon carbide may be one of the major etiologic agents in this case of pneumoconiosis.

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Section: Chemical Analysis Of Individual Particles By Analytical Elecmentioning

confidence: 99%

Silicon Carbide in Lung Tissue of a Worker in the Abrasive Industry

Hayashi

Kajita

1988

American J Industrial Med

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“…Chrysotile and tremolite data are from USGS (Virta 2002). Amosite data were obtained from Hayashi et al (1978). Crocidolite composition was averaged from the data of Shedd (1985).…”

Section: Methodsmentioning

confidence: 99%

Empirical model of mesothelioma potency factors for different mineral fibers based on their chemical composition and dimensionality

Korchevskiy¹,

Rasmuson²,

Rasmuson³

2019

Inhalation Toxicology

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Context: The potency of various mineral fiber types to produce mesothelioma was previously evaluated for numerous cohorts, but the differences in potencies for distinct fiber types have yet to be explained. Objective: To develop an empirical model that would reconstruct mesothelioma potency factors for various types of fiber based on their chemical composition and dimensionality. Methods: Typical chemical composition and dimensionality metrics (aspect ratios) were obtained and combined with mesothelioma potency factors estimated by Hodgson and Darnton method for Quebec chrysotile, South Africa amosite, South Africa and Australian crocidolite, Russian anthophyllite, Libby amphiboles, and Turkey erionite. The forward stepwise log-log regression method was utilized to determine the best combination of input parameters. Results: Mesothelioma potency factors (R M) for selected cohorts were effectively reconstructed utilizing the median aspect ratio of fibers and equivalent fractions of SiO 2 , total Fe oxides or total equivalent Fe 3þ as Fe 2 O 3 , and MgO. Modeled potency factors increase as the aspect ratio, SiO 2 , and total Fe oxide (or Fe 2 O 3) content grow, and as the MgO content diminishes. Correlation coefficients up to 0.999, p < 0.01, were achieved. The models also yield reasonable estimates of mesothelioma potencies for other fiber types, including Bolivian crocidolite, Russian chrysotile, fluoro-edenite, and others. Conclusion: In spite of the empirical approach, the proposed models provide a starting point for targeted studies of mesothelioma mechanisms by elucidating significant contributing physicochemical factors. The models have an exploratory and preliminary character but can potentially be useful to introduce quantitative structure-activity relationship approaches for the toxicology of fibrous minerals.

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Mineral dusts in lungs with scar or scar cancer

Yao

Wang

Michel

et al. 1984

Cancer

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Five lungs with small scars and five lungs with small scar associated cancers, were studied by light and scanning electron microscopy and x‐ray energy dispersive spectrometry. Six hundred particles were photographed and their physical and chemical properties analyzed from scar, cancer, or normal alveolar tissue on carbon planchet‐mounted, deparaffinized and low temperature‐ashed sections. Amosite/crocidolite fibers were accumulated only in one cancerous lung. All other lungs shared similar types of mineral particles. The lungs with noncancer scars, however, showed an increase in the ratio of aluminum and calcium salts (non‐silicates), while the lungs with scar cances had a higher ratio of silicates. These patterns of particle distribution were similar in different areas of the same lung, despite the fact that particles accumulated heavily in the scar and scarcely in the normal alveolus. Although the mechanism is unclear, these results are consistent with the possibility that the pattern of mineral particle distribution in a lung may influence the formation of cancer in a scar.

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Semiquantitative Chemical Analysis of Asbestos Fibers and Clay Minerals with an Analytical Electron Microscope

Cited by 14 publications

References 14 publications

Silicon Carbide in Lung Tissue of a Worker in the Abrasive Industry

Silicon Carbide in Lung Tissue of a Worker in the Abrasive Industry

Empirical model of mesothelioma potency factors for different mineral fibers based on their chemical composition and dimensionality

Mineral dusts in lungs with scar or scar cancer

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