Semisynthesis of Derivatives of Oleanolic Acid from<i>Syzygium aromaticum</i>and Their Antinociceptive and Anti-Inflammatory Properties

Rali, Sibusiso; Oyedeji, Opeoluwa O.; Aremu, Olukayode; Oyedeji, Adebola O.; Nkeh-Chungag, Benedicta N.

doi:10.1155/2016/8401843

Cited by 30 publications

(17 citation statements)

References 28 publications

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“…An alcoholic solution of the obtained acid is poured into a 5-fold volume of water to form a precipitate of AOA. The NMR data of the obtained crystalline product coincided with those known in the literature [21]. NMR 13 BA and OA are isolated from the outer bark or from the alcohol extract by a more polar solvent: diethyl or methyl tert-butyl ether (MTBE) together with betulin.…”

Section: Resultssupporting

confidence: 73%

Search for a Source of Triterpene Acids in Russian Birches

Vedernikov

Eregina

Shemyakina

2020

JCPRM

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The composition of triterpene acids and triterpene alcohols of the outer bark of a damaged silver birch tree (Betula pendula Roth.) the outer bark of silver birch branches, the outer bark of Betula davurica Pall., B. mandshurica (Regel) Nakai, B. platyphylla Sucacz. and B. costata Trautv. is considered. Silver birch bark was harvested in the Leningrad region. The bark of other species of birches was harvested in the Khabarovsk region. The qualitative composition of triterpene compounds was determined by chromatography-mass spectrometry. The quantitative composition was determined by gas-liquid chromatography and absolute calibration. Butyl esters of acids were preliminarily prepared for GLC analysis of triterpene acids. The outer bark of the eastern species of birches contains significantly more betulinic and oleanolic acid than silver birch. The relative content of triterpene acids is greater in the outer bark of branches and in the bark of damaged silver birches. The increase in acid content is apparently associated with the desire to heal a wound. The main component among the triterpenoids of the investigated raw materials is betulin. For the separation of acids from other triterpenoids, various solubilities of the compounds in solvents and the ability of acids to form poorly soluble salts were used.

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Section: Resultssupporting

confidence: 73%

Search for a Source of Triterpene Acids in Russian Birches

Vedernikov

Eregina

Shemyakina

2020

JCPRM

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“…The active phenolic compounds gallic acid and quercetin reported previously in this plant [ 23 ] might have resulted this activity. Similarly, several other compounds isolated from S. cumini leaves, myricetin, quercetin, acetylated flavonol glycosides, triterpenoids and tannin have also been reported to possess analgesic property [ 33 , 34 ]. The analgesic activity shown by S. samarangen can also be correlated to the present study [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Proliferative, Analgesic and Anti-Inflammatory Properties of Syzygium mundagam Bark Methanol Extract

2020

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Cancer, pain and inflammation have long been a cause for concern amongst patients, clinicians and research scientists. There is an alarming increase in the demand for medicines suppressing these disease conditions. The present study investigates the role of Syzygium mundagam bark methanol (SMBM) extract against MCF-7 breast cancer cells, pain and inflammation. The MCF-7 cells treated with SMBM were analyzed for adenosine triphosphate (ATP), lactate dehydrogenase (LDH) levels, changes in cell morphology and nuclear damage. Hot plate, acetic acid and formalin-induced pain models were followed to determine the analgesic activity. Anti-inflammatory activity was studied using carrageenan, egg albumin and cotton pellet induced rat models. Microscopic images of cells in SMBM treated groups showed prominent cell shrinkage and nuclear damage. Hoechst stain results supported the cell death morphology. The decline in ATP (47.96%) and increased LDH (40.96%) content indicated SMBM induced toxicity in MCF-7 cells. In the in vivo study, a higher dose (200 mg/kg) of the extract was found to be effective in reducing pain and inflammation. The results are promising and the action of the extract on MCF-7 cells, pain and inflammation models indicate the potential of drugs of natural origin to improve current therapies.

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“…Acetate and ester derived compounds of oleanolic acid, a triterpenoid compound, isolated from ethyl acetate extract of clove, were tested for their anti-in lammatory activity against albumin injected Wistar rats. Both the derived compounds besides having analgesic effects inhibited right hind paw in lammation, the acetyl derivatives being more potent (Rali et al, 2016). Eugenol obtained from clove oil inhibited collagen induced arthritis in DBA1/J mice by inhibiting in iltration of mononuclear cells and reducing in lammatory cytokines like TNF-α, IFN-γ and TGFβ in the knee and ankle joints respectively (Grespan et al, 2012).…”

Section: Clovementioning

confidence: 99%

The curative role of some dietary spices in inϑlammation

Sarkar¹

2020

ijrps

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Spices are mainly plants or their parts which lends an aroma or flavour to food. They form an integral part of Indian cuisine and are used to flavour and preserve our daily food besides other uses. Their immense traditional uses as diuretic, purgative etc. have been known to man since time immemorial. The traditional use to treat ailments has only currently been scientifically validated. The study of the pharmacological principles responsible for the activity of crude spices has also gained importance in recent times. Some of the spices used daily in Indian cuisine have been known to possess major anti-inflammatory effects. When the body is injured, it mounts a protective inflammatory response to prevent further injury or infection. In spite of its apparently docile nature, inflammation may sometimes cause extensive tissue damage. This condition is extremely dangerous if left untreated. The review underlines the importance of some of the frequently used spices in the treatment of inflammation. It also highlights the molecular mechanisms responsible for the reduction in inflammation by these spices and further investigates the active principle responsible for the same from the various studies done in this field in an attempt to highlight the importance of spices in our lives.

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Semisynthesis of Derivatives of Oleanolic Acid fromSyzygium aromaticumand Their Antinociceptive and Anti-Inflammatory Properties

Cited by 30 publications

References 28 publications

Search for a Source of Triterpene Acids in Russian Birches

Search for a Source of Triterpene Acids in Russian Birches

Anti-Proliferative, Analgesic and Anti-Inflammatory Properties of Syzygium mundagam Bark Methanol Extract

The curative role of some dietary spices in inϑlammation

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