Semisynthetic bioactive organoselenium and organotellurium compounds

Organic selenocompounds: are they the panacea for human illnesses?

“…, with biological activities have been synthesized in different laboratories. 125,179–208 Unfortunately, they have been rarely tested in models related to their recognized biological effects. For instance, in a recent elegant and rational study, 209 the neurochemical behavior of selenofluoxetine was compared with fluoxetine by quantifying the cerebral (hippocampal) serotonin levels in living mice.…”

Electrochemical selenylative ipso-annulation of N-benzylacrylamides to construct seleno-azaspiro[4.5]decadienones

“…Organoselenium compounds have been recognised as valuable molecules in the fields of agrochemicals, pharmaceuticals and material science. 1,2 Hence, the construction of these molecules has received considerable attention from synthetic organic chemists. 2–4 In the last two decades, metal-catalyzed cross-coupling reactions and radical-based methods mediated by peroxides and photoredox catalysts have been frequently used.…”