Semisynthetic d-His1,Nϵ-acetimidoglucagon: Structure-function relationships

Mahrenholz, Alan M.; Flanders, Kathleen C.; Hoosein, Naseema M.; Gurd, Frank R. N.; Gurd, Ruth S.

doi:10.1016/0003-9861(87)90580-7

Search citation statements

Order By: Relevance

Paper Sections

Select...

Other Hormones1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1990

1997

Publication Types

Select...

Article3

Book2

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an operation that has clear implications for all those concerned with pharmaceutically active polypeptides, Mahrenholz et al (1987) replaced His-l of glucagon with its D-analog. The resulting analog is a full agonist of the native hormone in the adenylate cyclase assay, but the affinity of binding to the receptor has fallen to approximately 1 % of the native value.…”

Section: Other Hormonesmentioning

confidence: 99%