2024
DOI: 10.1093/pnasnexus/pgae375
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Sendai virus-mediated RNA delivery restores fertility to congenital and chemotherapy-induced infertile female mice

Mito Kanatsu-Shinohara,
Hiroko Morimoto,
Tianjiao Liu
et al.

Abstract: Current infertility treatment strategies focus on mature gametes, leaving a significant proportion of cases with gamete progenitors that stopped complete differentiation. On the other hand, recent advancements in next-generation sequencing have identified many candidate genes that may promote maturation of germ cells. Although gene therapy has shown success in mice, concerns about the integration of DNA vectors into oocytes hinder clinical applications. Here, we present the restoration of fertility in female m… Show more

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