1954
DOI: 10.1038/bjc.1954.49
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Senecio Alkaloids: Primary Liver Tumours in Rats as a Result of Treatment with (1) A Mixture of Alkaloids from S. Jacobaea Lin.; (2) Retrorsine; (3) Isatidine

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Cited by 130 publications
(48 citation statements)
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“…Seven animals showed no gross hepatic lesions. In the other animals, liver changes varied from simple hyperplasia through trabecular hepatoma to a metastasising carcinoma (in one animal) (Schoental et al, 1954).…”
Section: Carcinogenicitymentioning
confidence: 99%
“…Seven animals showed no gross hepatic lesions. In the other animals, liver changes varied from simple hyperplasia through trabecular hepatoma to a metastasising carcinoma (in one animal) (Schoental et al, 1954).…”
Section: Carcinogenicitymentioning
confidence: 99%
“…The liver is the main carcinogenic target. However, tumors induced by PAs also were found in lung, kidney, skin, bladder, brain and spinal cord, pancreatic islets and adrenal gland (Allen et al, 1975;Brandange et al, 1970;Chan et al, 1994;Cook et al, 1950;Furuya et al, 1976;Harris and Chen, 1970;Hirono et al, 1976Hirono et al, , 1977Hirono et al, , 1978Hirono et al, , 1979Hirono et al, , 1983Johnson et al, 1978;Kuhara et al, 1980;Mattocks and Cabral, 1982;Mori et al, 1984;Peterson et al, 1983;Rao et al, 1983;Rao and Reddy, 1978;Schoental, 1975;Schoental and Cavanagh, 1972;Schoental et al, 1954Schoental et al, , 1970Schoental et al, , 1971Schoental and Head, 1957;Shumaker et al, 1976;Reddy, 1972, 1974;Williams, 1970). Despite no clear evidence that PAs induce tumors in humans, the frequent occurrence of primary liver tumors in the natives of Central Africa and South Africa has been associated with the consumption of traditional medicinal PA-containing plants (Pavlica and Samuel, 1970;Schoental, 1968;Schoental and Coady, 1968;Williams et al, 1967).…”
Section: Carcinogenicity and Hepatotoxicitymentioning
confidence: 99%
“…injection of lasiocarpine with a cumulative dose of 125 mg resulted in hepatocellular carcinomas in 61 % and squamous cell carcinomas of the skin in 33% of the rats . In an earlier investigation by Harris and (1hen (1970) (Schoental et al, 1954). This difference in histogenetic types of tumours in the liver illustrates the effect of the dose and mode of administration of various alkaloids on the susceptibility of different cell types in a given target organ.…”
Section: Discussionmentioning
confidence: 84%
“…Moreover, these toxins are also implicated in the causation of human liver diseases such as venoocclusive disease, cirrhosis of liver and possibly hepatocellular carcinoma (Schoental, 1968(Schoental, , 1972. Because ofpossible contamination of foodstuffs and their use as herbal remedies in developing nations, these alkaloids are considered as health hazards to man.Chronic administration of some of these alkaloids is known to cause liver tumours in experimental animals (Schoental, Head and Peacock, 1954;Harris and Chen, 1970 …”
mentioning
confidence: 99%
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