Senecio scandens Buch.-Ham.: A review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity

Wang, Dongmei; Huang, Linfang; Chen, Shilin

doi:10.1016/j.jep.2013.05.048

Cited by 53 publications

(25 citation statements)

References 61 publications

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“…Anal-genital distance, age at which eyes of pups opened and post-natal death of pups were within the normal ranges. Neonates are highly susceptible to phytotoxins due to the potential synergy with their high liver copper levels (Wang et al, 2013). Postnatal exposure to phytoestrogens can also induce endocrine disruptions and causes adverse reproductive and neurobehavioral effects (Ryökkynen et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

“…Postnatal exposure to phytoestrogens can also induce endocrine disruptions and causes adverse reproductive and neurobehavioral effects (Ryökkynen et al, 2006). Terpenoids, flavonoids, and their glycosides from S. scandens are estrogenic (Wang et al, 2013;Shrestha et al, 2014). Higher doses of phytoestrogens induced adverse effect on brain aromatase and neurobehavioral activities but lower doses did not (Setchell et al, 1997;Wisniewski et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

“…Senecio scandens Buch.-Ham. is a common species used in folklore medicines in Asia (Wang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Reproductive toxicity assessment of Senecio scandens extract in kunming mice

Ayisi¹,

Nie²,

Zeng-Jie³

et al. 2019

IJAR

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This study assessed the effects of Senecio scandens Buch. Ham.extract on reproductive spectrum in female mice using a three phase reproductive assessment method. Sperm abnormality rate was used to evaluate effect on genetic reproductive toxicity. Senecio scandens extract was relatively non-toxic at low doses in all phases of reproduction in female mice. However, it showed a dose-response effect on sperm abnormality rate, and at high doses has the potential to induce genetic reproductive toxicity in male mice. It is suggested that the well-understood pharmacological benefits of S. scandens extract as an herbal medicine far outweigh the minimal reproductive toxicity effects observed in this study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Reproductive toxicity assessment of Senecio scandens extract in kunming mice

Ayisi¹,

Nie²,

Zeng-Jie³

et al. 2019

IJAR

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“…Although seneciolactone has already been reported from this plant, but till date there are no reports on the antibacterial effect of seneciolactone against these gastrointestinal tract disease causing microbes. However, extracts of S. scandens have been shown to possess a wide range of pharmacological activities including anti-inflammatory, antimicrobial, hepatoprotective, antioxidant, antiviral, antitumor, mutagenic and toxicological activities (Wang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of seneciolactone isolated from Senecio scandens against some common gastrointestinal tract disease causing bacterial pathogens

Zheng

Wang

Shang

2016

Bangladesh J Pharmacol

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The objective of the present investigation was to study the antibacterial effect of seneciolactone isolated from the methanolic extract of Senecio scandens against five bacterial pathogens which are known to cause several gastrointestinal tract diseases. Disc diffusion assay and agar well diffusion assays were used to examine the antibacterial efficacy of this compound by measuring zones of inhibition and MIC/MBC values. Scanning electron microscopy (SEM) was involved to study the effect of this compound on cellular morphology of Shigella dysenteriae. Results revealed that seneciolactone exhibited moderate to potent antibacterial activity against different bacterial strains. Zones of inhibition and MIC/MBC values indicated that seneciolactone was most potent against S. dysenteriae followed by Pseudomonas aeruginosa and E. coli. SEM results indicated that seneciolactone induced potent damage to the cell membrane of the tested bacteria. As compared to the untreated control which exhibited normal cellular morphology, the seneciolactone treated bacterial cells revealed severe damage to the cellular membrane particularly at the higher doses.

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“…26,32) Therefore, individuals who consume herbal remedies or herbal teas made from Senecio plants are at risk of developing irreversible acute and/or chronic toxicities, 33,34) including acute liver failure, cirrhosis, pneumonitis, pulmonary hypertension and heart failure. 35) Poisoning cases are widely distributed in all ages, but are more common in children. 9) Today, several countries have restricted the use of Senecio.…”

Section: Discussionmentioning

confidence: 99%

Ninety-Day Subchronic Oral Toxicity Study of Senecio scandens Extract in Rats

Wang

Zhao

Liu

et al. 2015

Biological & Pharmaceutical Bulletin

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The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female rats at a single dose of 225, 450, and 900 mg/kg/d. There was no obvious toxicity. Certain changes in hematology and coagulation parameters (red cell distribution width (RDW), platelet count (PLT), monocyte percentage (Mo%), activated partial thromboplastin time (APTT), prothrombin time (PT)) were observed in some administration groups. In regards to the blood biochemical parameters, the levels of creatinine (CRN), potassium, and chloride were increased in a number of the treated rats. There were no significant changes in other hematology, coagulation, or biochemical parameters in rats orally administered S. scandens. S. scandens has a slight effect on rat coagulation and metabolism systems. The herb was safe at all doses tested, but caution should be taken when administering S. scandens at higher doses.

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Senecio scandens Buch.-Ham.: A review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity

Cited by 53 publications

References 61 publications

Reproductive toxicity assessment of Senecio scandens extract in kunming mice

Reproductive toxicity assessment of Senecio scandens extract in kunming mice

Antibacterial activity of seneciolactone isolated from <i>Senecio scandens</i> against some common gastrointestinal tract disease causing bacterial pathogens

Ninety-Day Subchronic Oral Toxicity Study of <i>Senecio scandens</i> Extract in Rats

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