Senegal, a new potential endemic country for Buruli ulcer?

Dupechez, Lucie; Carvalho, P.; Hébert, V.; Marsollier, Laurent; Eveillard, Matthieu; Marion, Estelle; Kempf, Marie

doi:10.1016/j.ijid.2019.09.020

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Since the number of geo-located confirmed occurrences and availability of data on spatial covariates prior to 1991 was limited, we were not able to stratify the analysis by time period. Cases of BU have recently been reported in Senegal [77,78] and Madagascar [79], where occurrence was not predicted by the model. Assuming these recent cases represent true instances of autochthonous transmission of M. ulcerans, this demonstrates a limitation of these models in their ability to predict emergent foci in regions that are environmentally distinct from known-endemic areas.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 88%

Mapping suitability for Buruli ulcer at fine spatial scales across Africa: A modelling study

et al. 2021

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Buruli ulcer (BU) is a disabling and stigmatising neglected tropical disease (NTD). Its distribution and burden are unknown because of underdiagnosis and underreporting. It is caused by Mycobacterium ulcerans, an environmental pathogen whose environmental niche and transmission routes are not fully understood. The main control strategy is active surveillance to promote early treatment and thus limit morbidity, but these activities are mostly restricted to well-known endemic areas. A better understanding of environmental suitability for the bacterium and disease could inform targeted surveillance, and advance understanding of the ecology and burden of BU. We used previously compiled point-level datasets of BU and M. ulcerans occurrence, evidence for BU occurrence within national and sub-national areas, and a suite of relevant environmental covariates in a distribution modelling framework. We fitted relationships between BU and M. ulcerans occurrence and environmental predictors by applying regression and machine learning based algorithms, combined in an ensemble model to characterise the optimal ecological niche for the disease and bacterium across Africa at a resolution of 5km x 5km. Proximity to waterbodies was the strongest predictor of suitability for BU, followed potential evapotranspiration. The strongest predictors of suitability for M. ulcerans were deforestation and potential evapotranspiration. We identified patchy foci of suitability throughout West and Central Africa, including areas with no previous evidence of the disease. Predicted suitability for M. ulcerans was wider but overlapping with that of BU. The estimated population living in areas predicted suitable for the bacterium and disease was 46.1 million. These maps could be used to inform burden estimations and case searches which would generate a more complete understanding of the spatial distribution of BU in Africa, and may guide control programmes to identify cases beyond the well-known endemic areas.

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Section: Plos Neglected Tropical Diseasesmentioning

confidence: 88%

Mapping suitability for Buruli ulcer at fine spatial scales across Africa: A modelling study

et al. 2021

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“…In West Africa, BU has replaced leprosy as the second mycobacterial disease [18] . Sporadic cases of BU have been described in non-endemic areas with appearance of new emerging areas in Africa (Senegal, Mali) and Asia (Japan) [19] , [20] , [21] .…”

Section: Introductionmentioning

confidence: 99%

Systematic review: Global host range, case fatality and detection rates of Mycobacterium ulcerans in humans and potential environmental sources

Tchatchouang,

Andre Mbongue Mikangue,

Kenmoe

et al. 2024

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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“…Two West African countries that were not previously established as endemic countries for Buruli ulcer have recently reported cases of this disease, suggesting an ongoing geographic extension of the epidemic in the sub-region. [1][2][3][4] These results prompted us to investigate Buruli ulcer in Burkina Faso by swabbing chronic wounds from patients living in rural areas.…”

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confidence: 99%

Confirming Autochthonous Buruli Ulcer Cases in Burkina Faso, West Africa

Millogo

Zingué

Bouam

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Environmental Mycobacterium ulcerans causes a disabling skin disease called Buruli ulcer. Recent studies completed the knowledge of the evolving geographic extension and epidemiology of Buruli ulcer in West Africa, where Côte d’Ivoire is reporting the highest number of cases. We report seven polymerase chain reaction-documented patients in Burkina Faso, a neighboring country of Côte d’Ivoire, where previously Buruli ulcer cases were confirmed primarily using clinical arguments.

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Senegal, a new potential endemic country for Buruli ulcer?

Cited by 5 publications

References 8 publications

Mapping suitability for Buruli ulcer at fine spatial scales across Africa: A modelling study

Mapping suitability for Buruli ulcer at fine spatial scales across Africa: A modelling study

Systematic review: Global host range, case fatality and detection rates of Mycobacterium ulcerans in humans and potential environmental sources

Confirming Autochthonous Buruli Ulcer Cases in Burkina Faso, West Africa

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