Senescence of endplate osteoclasts induces sensory innervation and spinal pain
Dayu Pan,
Kheiria Gamal Benkato,
Xuequan Han
et al.
Abstract:Spinal pain affects individuals of all ages and is the most common musculoskeletal problem globally. Its clinical management remains a challenge as the underlying mechanisms leading to it are still unclear. Here, we report that greater numbers of senescent osteoclasts (SnOCs) are observed in mouse models of spinal hypersensitivity, like lumbar spine instability (LSI) or aging, compared to controls. The larger population of SnOCs is associated with induced sensory nerve innervation, as well as the growth of H-t… Show more
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