Senescence, sleep, and circadian rhythms

Pandi-Perumal, Seithikurippu R.; Seils, L.K; Kayumov, Leonid; Ralph, Martin R.; Lowe, Alan D.; Moller, Henry J.; Swaab, Dick F.

doi:10.1016/s1568-1637(02)00014-4

Cited by 130 publications

(95 citation statements)

References 230 publications

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“…Thus, in general, they have trouble maintaining a consolidated sleep state. Similar problems are known to occur in elderly humans, but the mechanisms are not wellunderstood (Pandi-Perumal et al 2002). Our fly studies suggest that although circadian regulation may be disrupted with age, this is probably not the sole cause of the sleep disturbances in old flies.…”

Section: Sleep In Drosophilamentioning

confidence: 49%

Molecular Analysis of Sleep: Wake Cycles inDrosophila

Sehgal¹,

Joiner²,

Crocker³

et al. 2007

Cold Spring Harbor Symposia on Quantitative Biology

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Section: Sleep In Drosophilamentioning

confidence: 49%

Molecular Analysis of Sleep: Wake Cycles inDrosophila

Sehgal¹,

Joiner²,

Crocker³

et al. 2007

Cold Spring Harbor Symposia on Quantitative Biology

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“…However, of the sleep parameters examined, daily sleep bout number showed the clearest change and was least variable. Changes in these sleep parameters indicate that sleep becomes fragemented in aging flies as it does in aging humans (1). In contrast, unlike in humans, total sleep amount did not decrease with age; there was a moderate increase in sleep amount and a corresponding de-crease in activity counts in aging females, whereas these measures changed little after the first 3 weeks in males (Fig.…”

Section: Resultsmentioning

confidence: 88%

“…One of the most striking is the loss of sleep consolidation, namely increased daytime sleep and increased nighttime wakefulness in the elderly (1). In fact, loss of sleep consolidation has been used as one of several measures of frailty in elderly people (2).…”

mentioning

confidence: 99%

A Drosophila model for age-associated changes in sleep:wake cycles

Koh

Evans²,

Hendricks³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

315

291

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One of the most consistent behavioral changes that occurs with age in humans is the loss of sleep consolidation. This can be quite disruptive and yet little is known about its underlying basis. To better understand the effects of aging on sleep:wake cycles, we sought to study this problem in Drosophila melanogaster, a powerful system for research on aging and behavior. By assaying flies of different ages as well as monitoring individual flies constantly over the course of their lifetime, we found that the strength of sleep:wake cycles decreased and that sleep became more fragmented with age in Drosophila. These changes in sleep:wake cycles became faster or slower with manipulations of ambient temperature that decreased or increased lifespan, respectively, demonstrating that they are a function of physiological rather than chronological age. The effect of temperature on lifespan was not mediated by changes in overall activity level or sleep amount. Flies treated with the oxidative stress-producing reagent paraquat showed a breakdown of sleep:wake cycles similar to that seen with aging, leading us to propose that the accumulation of oxidative damage with age contributes to the changes in rhythm and sleep. Together, these findings establish Drosophila as a valuable model for studying age-associated sleep fragmentation and breakdown of rhythm strength, and indicate that these changes in sleep:wake cycles are an integral part of the physiological aging process.aging ͉ circadian rhythms ͉ sleep fragmentation

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“…A disruption of this rhythm may contribute to body weight dysregulation and obesity (Laughlin & Yen 1997, Matkovic et al 1997, Balligand et al 1998, Støving et al 1998 and an interference in the maintenance of bone mass (Ducy et al 2000, Elefteriou et al 2005). This could be particularly evident during aging, as loss of circadian rhythmicity or an attenuation of the amplitude of many circadian rhythms appears to be a characteristic of aging (Schwartz 1993, Touitou et al 1997, Touitou & Haus 2000, Downs et al 2001, Pandi-Perumal et al 2002, Urbanski et al 2004. Little is currently known about the effect of aging on the 24-h pattern of circulating leptin.…”

Section: Introductionmentioning

confidence: 99%

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Downs

Urbanski

2006

Journal of Endocrinology

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The adipocyte-derived hormone leptin plays a pivotal role in the regulation of body weight and energy homeostasis. Many studies have indicated that the circulating levels of leptin show a 24-h rhythm, but the exact cause and nature of this rhythm is still unclear. In the present study, we remotely collected blood samples every hour from young and old, male and female rhesus monkeys, and examined their 24-h plasma leptin profiles. In both the young males (10-11 years) and females (7-13 years), a clear 24-h plasma leptin rhythm was evident with a peak occurring w4 h into the night and a nadir occurring w1 h into the day (lights on from 0700 to 1900 h). A 24-h plasma leptin rhythm was also observed in the old males (23-30 years), even when they were maintained under constant lighting conditions (continuous dim illumination of w100 lx). In marked contrast, plasma leptin concentrations were relatively constant across the day and night in old peri-and post-menopausal females (17-24 years), regardless of the lighting schedule. These data establish that rhesus monkeys, like humans, show a daily nocturnal rise in plasma leptin, and the magnitude of this rhythm undergoes a sex-specific aging-dependent attenuation. Furthermore, they suggest that the underlying endocrine mechanism may be driven in part by a circadian clock mechanism.

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Senescence, sleep, and circadian rhythms

Cited by 130 publications

References 230 publications

Molecular Analysis of Sleep: Wake Cycles inDrosophila

Molecular Analysis of Sleep: Wake Cycles inDrosophila

A Drosophila model for age-associated changes in sleep:wake cycles

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

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