2023
DOI: 10.3390/cells12192341
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Senescent Cells: Dual Implications on the Retinal Vascular System

Mohammad Reza Habibi-Kavashkohie,
Tatiana Scorza,
Malika Oubaha

Abstract: Cellular senescence, a state of permanent cell cycle arrest in response to endogenous and exogenous stimuli, triggers a series of gradual alterations in structure, metabolism, and function, as well as inflammatory gene expression that nurtures a low-grade proinflammatory milieu in human tissue. A growing body of evidence indicates an accumulation of senescent neurons and blood vessels in response to stress and aging in the retina. Prolonged accumulation of senescent cells and long-term activation of stress sig… Show more

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“…Stress and aging contribute to the accumulation of blood vessels and aging neurons in the retina [95]. Prolonged exposure to chronic activation of stress signaling responses and senescent cells may expose neighboring cells to an enhanced pathological senescenceassociated secretory phenotype, leading to tissue dysfunction, multiple chronic diseases, and age-related pathologies [95]. The intricate interplay of aging, hypertension, and diabetes exerts complex and crucial effects on the microvascular structure.…”
Section: Retinal Vascular Aging: Pathophysiologymentioning
confidence: 99%
“…Stress and aging contribute to the accumulation of blood vessels and aging neurons in the retina [95]. Prolonged exposure to chronic activation of stress signaling responses and senescent cells may expose neighboring cells to an enhanced pathological senescenceassociated secretory phenotype, leading to tissue dysfunction, multiple chronic diseases, and age-related pathologies [95]. The intricate interplay of aging, hypertension, and diabetes exerts complex and crucial effects on the microvascular structure.…”
Section: Retinal Vascular Aging: Pathophysiologymentioning
confidence: 99%