Senna singueana: Antioxidant, Hepatoprotective, Antiapoptotic Properties and Phytochemical Profiling of a Methanol Bark Extract

Sobeh, Mansour; Mahmoud, Mona F.; Hasan, Rehab A.; Cheng, Haroan; El-Shazly, Assem M.

doi:10.3390/molecules22091502

Cited by 51 publications

(39 citation statements)

References 46 publications

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“…d ‐GalN facilitates oxidative stress, hepatocellular necrosis, and programmed cell death . In our work, intraperitoneal injection of 500 mg·kg −1 d ‐GalN resulted in serious hepatocellular injury.…”

Section: Discussionsupporting

confidence: 51%

The effects of vitamins and selenium mixture against brain tissue induced byd‐galactosamine

Tunalı

Çatal

Bolkent

et al. 2019

J Biochem & Molecular Tox

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Brain damage is a major complication of fulminant hepatic failure. d‐Galactosamine (d‐GalN)‐induced liver toxicity causes damage to brain. The effects of vitamins and selenium mixture against d‐GalN stimulated brain injury were investigated in this study. Sprague‐Dawley female rats aged 2.0‐2.5 months were used for the study. The rats were divided into four categories. A 0.9% NaCl solution was intraperitoneally given to the experimental rats in the first group. Using gavage technique, the second group of animals were subjected to a formulation consisting of 100 mg·kg−1·day−1 vitamin C, 15 mg·kg−1·day−1 of β‐carotene, 100 mg·kg−1·day−1 of α‐tocopherol in addition to 0.2 mg·kg−1·day−1 of sodium selenate for 3 days. The third group was given a single dose of d‐GalN hydrochloride at the concentration of 500 mg·kg−1 through a saline injection. The final group was given similar concentrations of both the antioxidant combination and d‐GalN. Tissue samples were collected under ether anesthesia. The rats treated with d‐GalN showed brain damage; increased myeloperoxidase, catalase, glutathione peroxidase, glutathione‐S‐transferase, lactate dehydrogenase, and superoxide dismutase activities; and decreased glutathione levels. Treatment with vitamins and selenium combination resulted in alleviation of these alterations in the rats. These findings suggest that administration of the vitamins and selenium combination suppresses oxidative stress and protects brain cells from injury induced by d‐GalN.

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Section: Discussionsupporting

confidence: 51%

The effects of vitamins and selenium mixture against brain tissue induced byd‐galactosamine

Tunalı

Çatal

Bolkent

et al. 2019

J Biochem & Molecular Tox

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“…In conclusion, the polyphenolics in the bark extract are bioavailable and are partly taken up by C. elegans . The results agree with those of earlier experiments in our laboratory [ 18 , 19 , 20 , 21 ].…”

Section: Resultssupporting

confidence: 93%

HPLC-PDA-MS/MS Characterization of Bioactive Secondary Metabolites from Turraea fischeri Bark Extract and Its Antioxidant and Hepatoprotective Activities In Vivo

et al. 2017

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Turraea fischeri is an East African traditional herb, which is widely used in traditional medicine. In this study, we profiled the secondary metabolites in the methanol extract of T. fischeri bark using HPLC-PDA-ESI-MS/MS, and 20 compounds were tentatively identified. Several isomers of the flavonolignan cinchonain-I and bis-dihydroxyphenylpropanoid-substituted catechin hexosides dominated the extract. Robust in vitro and in vivo antioxidant properties were observed in 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay (DPPH) and ferric reducing antioxidant power (FRAP) assay, and in the model organism Caenorhabditis elegans. Additionally, the extract exhibited promising hepatoprotective activities in D-galactosamine (D-GaIN) treated rats. A significant reduction in the elevated levels of aspartate aminotransferase (AST), total bilirubin, gamma-glutamyltransferase (GGT), and malondialdehyde (MDA) and increase of glutathione (GSH) was observed in rats treated with the bark extract in addition to D-galactosamine when compared with rats treated with D-galactosamine alone. In conclusion, T. fischeri is apromising candidate for health-promoting and for pharmaceutical applications.

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“…alata 4 , other bark-tannins rich extracts from Albizia harveyi , Senna singueana , Turraea fischeri , and proanthocyanidin rich root extracts from Cassia abbreviata and Ximenia americana var. caffra 17 , 18 , 21 , 23 , 24 .…”

Section: Resultsmentioning

confidence: 99%

Tannin-rich extracts from Lannea stuhlmannii and Lannea humilis (Anacardiaceae) exhibit hepatoprotective activities in vivo via enhancement of the anti-apoptotic protein Bcl-2

Sobeh

Mahmoud

Hasan

et al. 2018

Sci Rep

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The potential hepatoprotective activities of two Lannea species were explored in vivo. Furthermore, the binding activities of their main polyphenols to the antiapoptotic protein Bcl-2 were investigated. Based on HPLC-MS/MS results, 22 secondary metabolites were characterized in L. stuhlmannii (mainly tannins), while 20 secondary metabolites (mainly sulphated tannins) were identified in L. humilis. Both extracts exhibited substantial antioxidant activities in vitro and counteracted D-galactosamine induced intoxication in rats in vivo and increased the total antioxidant capacity (TAC) of liver tissues. In addition to reducing the elevated levels of AST and total bilirubin, both extracts significantly attenuated the deleterious histopathologic changes in liver after D-galactosamine-intoxication. Also, both extracts protected hepatocytes from apoptotic cell death and increased the expression of the anti-apoptotic protein Bcl-2. The identified compounds from both extracts can bind to the Bcl-2: Bim (BH3) interface with an appreciable binding free energy. Hydrogen and ionic bonds and hydrophobic interactions with amino acid residues in the hydrophobic face of Bim (BH3) domain were discovered. To sum up, L. humilis and L. stuhlmanni exhibited promising hepatoprotective activities in vivo against D-GalN-induced liver injury and their hepatoprotection is due to the antioxidant and anti-apoptotic effects of tannins and proanthocyanidins.

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Senna singueana: Antioxidant, Hepatoprotective, Antiapoptotic Properties and Phytochemical Profiling of a Methanol Bark Extract

Cited by 51 publications

References 46 publications

The effects of vitamins and selenium mixture against brain tissue induced byd‐galactosamine

The effects of vitamins and selenium mixture against brain tissue induced byd‐galactosamine

HPLC-PDA-MS/MS Characterization of Bioactive Secondary Metabolites from Turraea fischeri Bark Extract and Its Antioxidant and Hepatoprotective Activities In Vivo

Tannin-rich extracts from Lannea stuhlmannii and Lannea humilis (Anacardiaceae) exhibit hepatoprotective activities in vivo via enhancement of the anti-apoptotic protein Bcl-2

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