Senolytic Phytocompounds in Redox Signaling

Astaxanthin attenuates irradiation-induced osteoporosis in mice by inhibiting oxidative stress, osteocyte senescence, and SASP

“…Recent studies strongly indicate that IR severely impairs the defense mechanisms of antioxidant stress responses and accelerates bone aging [41,49]. Supplementation with antioxidants is a useful approach to mitigate the damage caused by excessive ROS and cell senescence [50]. Studies in our laboratory have also shown Pyrroloquinoline Quinone (PQQ), a powerful antioxidant, prevents estrogen-deficiency-induced osteoporosis due to its impact on ROS levels and inhibiting cell senescence and SASP secretion [42].…”

“…41,49 Supplementation with antioxidants is a useful approach to mitigate the damage caused by excessive ROS and cell senescence. 50 Studies in our laboratory have also shown that pyrroloquinoline quinone (PQQ), a powerful antioxidant, prevents estrogen-deficiency-induced osteoporosis due to its impact on ROS levels and inhibits cell senescence and SASP secretion. 42 In this study, the level of ROS in the bone marrow, spleen, and thymus increased significantly after IR exposure (Fig.…”

Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components

“…As a result, cellular senescence appears to be a common denominator for a variety of human inflammatory diseases and it is argued that pathophysiologically distinct but age-dependent disorders should be considered within the purview of cellular senescence itself (Prašnikar et al 2021 ). As the cellular senescence-centric view of aging is being rapidly acknowledged; novel therapies aimed at mitigating or selectively removing SC (through senolytics) are of considerable interest for lifespan extension despite their potential pitfalls and apprehensions (Dolgin 2020 ; Owens et al 2021 ; Pils et al 2021 ; Sharma 2021a ; Thirumurugan 2022 ).…”