Young adults of college age are at particular risk for psychopathology, non-suicidal self-injury (NSSI) and consequent suicidal behavior, perhaps in a continuum of increasing severity. However, not all persons who experience psychopathological symptoms, or who self-harm, go on to engage in suicidal behavior, perhaps due to protective factors such as self-compassion that buffer this progression. We examined the mediating effect of NSSI on the relation between anxiety/depressive symptoms and suicide risk, and the moderating role of self-compassion on these linkages. Our collegiate sample (N=338) completed: Beck Depression Inventory, Beck Anxiety Inventory, Self-Harm Inventory, Suicidal Behavior Questionnaire-Revised, and the Self-Compassion Scale. Students with greater psychopathology reported more engagement in NSSI and, consequently, more suicide risk; self-compassion weakened the psychopathology-NSSI linkage. Therapeutically addressing risk factors for suicidal behavior (e.g., psychopathology, NSSI), and promoting self-compassion, may halt progression from symptomology to self-harm, thereby ultimately reducing suicide risk in college students. Prevalence of Suicide and Suicide-Related Behavior Over 800,000 individuals die by suicide worldwide each year, making it the 15 th leading cause of death across age groups and the 2 nd leading cause of death among individuals 15-29 years old (World Health Organization [WHO], 2014). In the United States, suicide is the 10 th leading cause of death and the 2 nd leading cause of death in young adults aged 15 to 24 years old, with an individual dying by suicide every 13 minutes (CDC, 2015). Suicide rates continue to rise, both nationally and globally (WHO, 2015; Xu et al., 2014); however, these rates of suicide may be underestimated, reported as accidents or homicides, given the social stigma often surrounding suicide (Timmermans, 2005). Even more common than death by suicide is suicide-related behavior, including suicidal ideation and suicide attempts, and it is estimated that, in the United States, there are as many as 25 suicide attempts for each death by suicide (Crosby, Han, Ortega, Parks, & Gfroerer, 2011). Prevalence of suicide attempts worldwide is 0.4%, or approximately 20 attempts for every death by suicide (WHO, 2015). Terminologically, suicide-related behavior (Silverman, Berman, Sanddal, O'Carroll, & Joiner, 2007) encompasses a continuum, ranging from suicidal ideation, or thoughts of suicide, to planning for suicide and, last, suicide attempts and death by suicide (Kachur, Potter, Powell, & Rosenberg, 1995). Suicidal ideation is defined as thoughts about killing oneself (e.g., "I wish I were dead"), and can include thoughts about a plan for suicide (i.e., the means one would use). A suicide attempt is defined as intentional self-inflicted injury performed to result in death, which differs from a death by suicide in that the individual does not end their life, as an attempt may or may not result in injury (Kazdin, 2000; Nock & Kessler, 2006). These behaviors decr...