Limited research has investigated the impact of immigrants’ sense of place (SOP) attitudes on their quality of life (QOL) outcomes, especially during crises such as the COVID-19 pandemic. The present study aimed to fill this gap by examining the effect of SOP attitudes and health-related QOL (HQOL) on 120 Iranian citizens residing in Budapest, Hungary, during the pandemic. Using social media platforms, an online survey was conducted between March and July 2020. The findings of this study revealed that SOP elements, such as connection to sites, location identification, and location reliance, are susceptible to change and rely on QOL during the pandemic. The study also highlighted that Budapest has the potential to become a desirable destination for future immigrants. Overall, this study contributes to the literature on the relationship between SOP attitudes and QOL outcomes among immigrants during a crisis. It provides valuable insights for policymakers and practitioners to improve the SOP and QOL of immigrants living in cities affected by pandemics or other crises. This study provides insights into the influence of a sense of place on the quality of life of Iranian immigrants by presenting a model and highlighting significant results in a selected community.