Disruption of legacy infrastructure systems by novel digital and connected technologies represents not simply the rise of cyberphysical systems as hybrid physical and digital assets but, ultimately, the integration of legacy systems into a new cognitive ecosystem. This cognitive ecosystem, an ecology of massive data flows, artificial intelligence, institutional and intellectual structures, and connected technologies, is poised to alter how humans and artificial intelligence understand and control our world. Infrastructure managers need to be ready for this paradigm shift, recognizing their systems are increasingly being absorbed into an emerging suite of data, analytical tools, and decisionmaking technologies that will fundamentally restructure how legacy systems behave and are controlled, how decisions are made, and most importantly how workers interact with the systems. Infrastructure managers must restructure their organizations and engage in cross-organizational sensemaking if they are to be capable of navigating the complexity of the cognitive ecosystem. The cognitive ecosystem is fundamentally poised to change what infrastructures are, necessitating the need for managers to take a close look at the functions and actions of their own systems. The continuing evolution of the Anthropocene and the cognitive ecosystem has profound implications for infrastructure education. A sustained commitment to change is necessary that restructures and reorients infrastructure organizations within the cognitive ecosystem, where knowledge is generated, and control of services is wielded by myriad stakeholders.