Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)

Naspitz, Charles K.; Solé, Dírceu; Jacob, Cristina A.; Sarinho, Emanuel; Soares, Francisco José Passos; Dantas, Vera Maria; Mallozi, Márcia C.; Wandalsen, Neusa Falbo; Borges, Wellington; Filho, Wilson Rocha; PROAL, Grupo

doi:10.1590/s0021-75572004000400008

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…On the other hand, several studies have reported associations between SPT positivity and asthma and gastroesophageal reflux. 38 In study by Ribeiro et al, the presence of respiratory infections and asthma attacks were associated with atopic parents but not with the presence of two or more positive skin tests for allergies among the children who were studied. In addition, the presence of respiratory infections and asthma were not associated with parents who smoked or with studying at boarding school.…”

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confidence: 91%

Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

et al. 2013

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CONTEXT AND OBJECTIVE: Knowledge of the profile of allergen sensitization among children is important for planning preventive measures. The objective of this study was to assess the prevalence and profile of sensitization to inhaled allergens and food among children and adolescents in an outpatient population in the city of Palmas. DESIGN AND SETTING: Cross-sectional study at outpatient clinics in Palmas, Tocantins, Brazil. METHODS: Ninety-four patients aged 1-15 years who were attending two pediatric outpatient clinics were selected between September and November 2008. All of the subjects underwent clinical interviews and skin prick tests. RESULTS:A positive skin prick test was observed in 76.6% of the participants (72.3% for inhalants and 28.9% for food allergens). The most frequent allergens were Dermatophagoides pteronyssinus (34%), cat epithelium (28.7%), dog epithelium (21.3%), Dermatophagoides farinae (19.1%), Blomia tropicalis (18.1%), cow's milk (9.6%) and grasses (9.6%). A positive skin prick test correlated with a history of atopic disease (odds ratio, OR = 5.833; P = 0.002), a family history of atopic disease (OR = 8.400; P < 0.001), maternal asthma (OR = 8.077; P = 0.048), pet exposure (OR = 3.600; P = 0.012) and cesarean delivery (OR = 3.367; P = 0.019). CONCLUSION: Dermatophagoides pteronyssinus was the most frequent aeroallergen and cow's milk was the most prevalent food allergen. There was a positive correlation between a positive skin prick test and several factors, such as a family history of atopic disease, maternal asthma, pet exposure and cesarean delivery.RESUMO CONTEXTO E OBJETIVO: O conhecimento sobre o perfil da sensibilização a alérgenos em crianças é importante para o planejamento de medidas preventivas. O objetivo deste estudo foi avaliar a prevalência e perfil de sensibilização a alérgenos inalados e alimentares em crianças e adolescentes em uma população ambulatorial na cidade de Palmas. TIPO DE ESTUDO E LOCAL: Estudo transversal em unidades ambulatoriais em Palmas, Tocantins, Brasil. MÉTODOS: Foram selecionados 94 pacientes com idades entre 1 a 15 anos em 2 ambulatórios de pediatria entre setembro e novembro de 2008. Todos os sujeitos foram submetidos a entrevistas clínicas e testes cutâneos de puntura. RESULTADOS: Um teste cutâneo de puntura positivo foi observado em 76,6% dos participantes (72,3% para inalantes, 28,9% para alérgenos alimentares). Os alérgenos mais frequentes foram Dermatophagoides pteronyssinus (34%), epitélio de gato (28,7%), epitélio de cão (21,3%), Dermatophagoides farinae (19,1%), Blomia tropicalis (18,1%), leite de vaca (9,6%) e gramíneas (9,6%). Um teste cutâneo de puntura positivo foi relacionado à história de doença atópica (razão de chances RC = 5,833, P = 0,002), história familiar de atopia (RC = 8,400, P < 0,001), asma materna (RC = 8,077, P = 0,048), exposição a animal de estimação (RC = 3,600, P = 0,012) e parto cesáreo (RC = 3,367, P = 0,019). CONCLUSÃO: Dermatophagoides pteronyssinus foi o aeroalérgeno mais prevalente e, dentre alérgenos a...

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confidence: 91%

Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

et al. 2013

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“…In our opinion, there are no grounds for the current movement, according to social networks, that all patients with CD should avoid cutaneous and inhalation exposure to wheat. Based on the frequency of sensitization to wheat in patients with CD equaled 4% in our study, it is still a lower proportion than the general population of the same country that was equal to 9.4% [25]. It is also important to note that most patients who had sensitization to wheat did not show symptoms when they did not follow GFD.…”

Section: Discussion/conclusionmentioning

confidence: 55%

“…Brazilian and Latin American studies are scarce. Two Brazilian multicentric studies evaluated WS in atopic patients and controls [24, 25]. The first one observed a frequency of 20.1% among atopic patients and 8.1% among controls [24]; the other study, 12 years later, observed an increase of these proportions, which were 23.4 and 9.4%, respectively [25].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned?

Lanzarin¹,

Silva²,

Venturieri³

et al. 2020

Int Arch Allergy Immunol

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Background: Concomitance of celiac disease (CD) and IgE-mediated wheat allergy is described in some case reports. The objective was to evaluate the frequency of sensitization to wheat, rye, barley, and malt in children and adolescents with CD. Methods: Measurement of serum levels of specific IgE to wheat, rye, barley, and malt (ImmunoCAP; sensitization IgE ≥0.35 kUA/L) in CD patients followed in specialized clinics to verify allergy history, general characteristics, small bowel biopsy characteristics, compliance with gluten-free diet (GFD), and occurrence of symptoms in case of noncompliance. Results: We evaluated 74 patients; the median of age and age at diagnosis of CD were 8.6 years (5.0–12.8) and 3.6 years (1.6–7.0), respectively. Median time of GFD was 3.5 years (1.4–5.8). History of asthma occurred in 17.3% of subjects, allergic rhinitis in 13.5%, and AD in 5.4%. Frequency of sensitization was 4% for wheat, 10.8% for rye, 5.4% for barley, and 2.7% for malt. There was no association between wheat sensitization and age at diagnosis, time of GFD, small bowel biopsy characteristics, allergy history, and gluten consumption. There was no relationship between sensitization to wheat and occurrence of immediate symptoms when not complying with GFD. Conclusion: In conclusion, the frequency of sensitization to wheat, rye, barley, and malt in CD patients was 4, 10.8, 5.4, and 2.7%, respectively. Therefore, to ensure that cutaneous and respiratory contact with wheat is safe, we advise patients with CD to investigate their sensitivity to wheat, rye, and barley because not all patients with CD are allergic to these cereals.

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“…1 The great variability found among total IgE values shows its low specificity for allergic diseases, in addition to its not being recommended for screening, once the increase in serum levels may occur in several clinical situations. 5 Frequency of positivity of specifi c IgE for dust mites (D. pteronyssinus) was higher in the control group (34.8%), suggesting that atopy is not related to anaphylaxis associated with vaccine.…”

Section: Resultsmentioning

confidence: 87%

Anafilaxia associada à vacina contra sarampo, caxumba e rubéola

Novadzki

Filho

2010

Rev. Saúde Pública

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A case-control study was carried out aiming to describe the cases and causes of anaphylaxis associated with the vaccine against measles, mumps and rubella. A total of 22 reported cases in children who showed mucocutaneous manifestations, during the Campanha Nacional de Vacinação (Brazilian Vaccination Campaign), conducted in the city of Curitiba, Southern Brazil, in 2004, were studied. In addition, 66 children, who were next to these cases and did not show a symptomatology after the vaccine was applied, were selected. Serum measurements of antibodies for vaccine antigens and total IgE, specifi c IgE antibody measurements for several allergens, and skin tests were performed. Vaccine response was adequate, specifi c IgE measurement and skin tests showed that potential allergens in vaccines and atopy were not associated with anaphylactic reactions. Skin tests with the vaccine and dextran were positive in the cases exclusively, suggesting sensitization to certain residual components of the vaccine and possible cross-reaction with dextran.

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Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica: Projeto Alergia (PROAL)

Cited by 6 publications

References 16 publications

Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned?

Anafilaxia associada à vacina contra sarampo, caxumba e rubéola

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