2018
DOI: 10.3389/fimmu.2018.00052
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Sensing Bacterial-Induced DNA Damaging Effects via Natural Killer Group 2 Member D Immune Receptor: From Dysbiosis to Autoimmunity and Carcinogenesis

Abstract: The human genome is constantly exposed to exogenous and endogenous DNA damaging factors that frequently cause DNA damages. Unless repaired, damaged DNA can result in deleterious mutations capable of causing malignant transformation. Accordingly, cells have developed an advanced and effective surveillance system, the DNA damage response (DDR) pathway, which maintains genetic integrity. In addition to well-defined outcomes, such as cell cycle arrest, apoptosis, and senescence, another consequence of DDR activati… Show more

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Cited by 33 publications
(33 citation statements)
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“…Studies have attempted to dissect the underlying mechanism behind the initiation and progression of PC in the context of inflammation 7,13 . The inflammatory milieu in association with the presence of microorganisms in BPH/prostatitis/PC involves oncogenic mechanisms like oxidative stress 10,14 and DNA damage 15‐19 . Inflammatory signaling involving nuclear factor‐κB (NF‐κB) 20‐22 and cyclooxygenase‐2 (COX2) 23,24 is also reported to be intricate in PC pathogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…Studies have attempted to dissect the underlying mechanism behind the initiation and progression of PC in the context of inflammation 7,13 . The inflammatory milieu in association with the presence of microorganisms in BPH/prostatitis/PC involves oncogenic mechanisms like oxidative stress 10,14 and DNA damage 15‐19 . Inflammatory signaling involving nuclear factor‐κB (NF‐κB) 20‐22 and cyclooxygenase‐2 (COX2) 23,24 is also reported to be intricate in PC pathogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…It may be used upon search the ways and strategies of fight against tumors (also throuph antiviral action). As a result, increase of a number of effective NK cells and NKP and their intratumor-tissue expansion (expansion of needed NK cell types and complex NKP combinations) take place [8,11,13,30]. Actions of NKP are in the synergistic accordance to protective actions of the complement system [18].…”
Section: разнообразие популяций киллерных клеток в коммуникациях протmentioning
confidence: 99%
“…It can be applied to work out strategies aimed at fighting against tumors including those incorporating antiviral effects. As a result, essential NK-cell types and populations grow in number and their expansion inside a tumor takes place [11,14,15,27]. Effects produced by NK-populations are coordinated with the complement system [21].…”
Section: Variety Of Nk-populations Typed By Receptor Lectinsmentioning
confidence: 99%
“…*Targeted application of NKG2D+-populations against tumors with the use of NKG2D-receptors belonging to supervisory effector NK-cells which act in a stand-by mode and monitor occurrence / initiation of tumor ligands on stress cells as such ligands are tumor precursors [8,14]. And here cells that express NKG2D-ligands (as it happens in case of super-expression of sets in stress cells insides the intestines) are recognized and eliminated by supervisory cells and it is aimed at preventing carcinogenesis, for example, rectum cancer [14].…”
Section: Variety Of Nk-populations Typed By Receptor Lectinsmentioning
confidence: 99%
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