Sensing methods for stress biomarker detection in human saliva: a new frontier for wearable electronics and biosensing

Pandit, Parth; Crewther, Blair; Cook, Christian; Punyadeera, Chamindie; Pandey, Ajay K.

doi:10.1039/d3ma00937h

Cited by 2 publications

References 160 publications

(167 reference statements)

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The MultiMusic multidomain intervention including choral practice in community-dwelling older people: A study protocol for Brain-Derived Neurotrophic Factor (BDNF) salivary biomarkers, audiometric and neuropsychological parameters

Lippolis,

Lenti,

Mantuano

et al. 2024

Preprint

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Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in neuroplasticity, supporting brain health along life and even during aging. This longitudinal study investigates the impact of a 9-month multidomain intervention, including choral practice, on BDNF levels, audiometric and neuropsychological outcomes, in older adults, assessed also for their multidimensional frailty, based on their physical, cognitive and nutritional conditions. BDNF levels, along with geriatric, neuropsychological, audiometric and neurophysiological measures, are taken, via saliva samples, both pre- and post- intervention. For BDNF longitudinal analyses, up to 60 elderly will be recruited from several recreational centers located in Southern Italy. Of them, a group will be engaged in a multidomain program including choir, physical, intellectual and manual activities. The other two control groups will engage in sporadic non-musical activities/no activity, or undergo various non-musical activities. Participation in all activities will be monitored via diaries. Our primary goal is to investigate whether engaging in physical, cognitive and social activities can enhance neuroplasticity as measured by BDNF levels, to contrast aspects of multidimensional frailty (as assessed by the multidimensional prognostic score, MPI) in the aging population. Secondly, we aim to relate changes in BDNF levels to the perceptual and cognitive spheres and psychosocial well-being. Although previous studies point out the positive effects of musical training and active aging on brain health, the scarcity of longitudinal research on effects on BDNF for older individuals keeps the issue open. Moreover, we aim to test whether non-invasive, accessible saliva-based BDNF measurements, despite some reliability limitations, could offer indications of neuroprotection in aging.

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The MultiMusic multidomain intervention including choral practice in community-dwelling older people: A study protocol for Brain-Derived Neurotrophic Factor (BDNF) salivary biomarkers, audiometric and neuropsychological parameters

Lippolis,

Lenti,

Mantuano

et al. 2024

Preprint

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Recent Progress in Saliva-Based Sensors for Continuous Monitoring of Heavy Metal Levels Linked with Diabetes and Obesity

Anchidin-Norocel,

Savage,

Nemțoi

et al. 2024

Chemosensors

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Sensors are versatile technologies that provide rapid and efficient diagnostic results, making them invaluable tools in public health for measuring and monitoring community exposure to environmental contaminants. Heavy metals such as lead, mercury, and cadmium, commonly found in food and water, can accumulate in the body and have toxic effects, contributing to the development of conditions like obesity and diabetes. Traditional methods for detecting these metals often require invasive blood samples; however, sensors can utilize saliva, offering a noninvasive and simplified approach for public health screening. The use of saliva as a diagnostic fluid represents a major advance in population health monitoring due to its low cost, noninvasiveness, and ease of collection. Recent advances in sensor technology have enabled the development of diagnostic tests that link heavy metal levels in saliva with the risk of developing obesity and diabetes. Optimizing these sensors could facilitate the identification of individuals or groups at risk, enabling targeted, personalized preventive measures. Sensors that use saliva for detecting heavy metals hold promise for diagnosing and preventing metabolic diseases, providing valuable insights into the link between heavy metal exposure and metabolic health.

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Sensing methods for stress biomarker detection in human saliva: a new frontier for wearable electronics and biosensing

Abstract: The human stress response triggers a complex array of physiological, psychological, and biochemical reactions, involving neuroendocrine pathways such as the sympathetic adrenomedullary axis and hypothalamic-pituitary-adrenal axis. Prolonged experience of stress...

Cited by 2 publications

References 160 publications

The MultiMusic multidomain intervention including choral practice in community-dwelling older people: A study protocol for Brain-Derived Neurotrophic Factor (BDNF) salivary biomarkers, audiometric and neuropsychological parameters

The MultiMusic multidomain intervention including choral practice in community-dwelling older people: A study protocol for Brain-Derived Neurotrophic Factor (BDNF) salivary biomarkers, audiometric and neuropsychological parameters

Recent Progress in Saliva-Based Sensors for Continuous Monitoring of Heavy Metal Levels Linked with Diabetes and Obesity

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