Sensing of DNA by graphene-on-silicon FET structures at DC and 101 GHz

Brown, E. R.; Zhang, W.-D.; Viveros, Leamon; Neff, David; Green, N.S.; Norton, Michael L.; Pham, Phi H. Q.; Burke, Peter J.

doi:10.1016/j.sbsr.2015.05.002

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…Therefore, 2D material-based nanoscale devices are actively being investigated for single-molecule bioelectronics. − Graphene as a biomolecule sensor has attracted considerable attention since it provides various sensing mechanisms such as charge transfer, charge scattering, and π–π stacking interactions . Furthermore, it is a zero-gap semiconductor capable of significantly upgrading the selectivity and sensitivity of field-effect transistor (FET) biosensors on the road to more efficient enzymatic biomolecule sensing − and DNA sequencing. , In particular, the interactions between amino acids and graphene have been extensively investigated by both experimentalists and theoreticians. ,,,,,,, However, the significantly low ON/OFF current ratio limits the use of graphene in bioelectronic device applications. Further, the van der Waals (vdW) interaction between the MoS 2 surface and amino acids was reported to be stable adsorption .…”

Section: Introductionmentioning

confidence: 99%

Individual Identification of Amino Acids on an Atomically Thin Hydrogen Boride System Using Electronic Transport Calculations

Kumawat¹,

Jena²,

Pathak³

2020

J. Phys. Chem. C

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Recently synthesized two-dimensional hydrogen boride (HB) with a hexagonal boron network offers excellent opportunities for nanoscale electronic device applications. Herein, we have proposed a type of field-effect transistor (FET) nanodevice based on a two-dimensional HB sheet for individual identification of amino acids. Using first-principles consistent-exchange van der Waals density-functional (vdW-DF-cx) calculations, we have studied the effects produced by the adsorption of each amino acid on the electronic properties of the HB-based nanodevice for its detection. The adsorption energies, adsorption heights, and the charge transfer of each amino acid can be deliberated as demonstrative of all 10 amino acids: alanine (Ala), arginine (Arg), aspartic (Asp), glutamic acid (Glu), glycine (Gly), histidine (His), lysine (Lys), phenylalanine (Phe), proline (Pro), and tyrosine (Tyr). Furthermore, the electronic transport properties of the HB nanodevice and HB + amino acid setup are studied by the nonequilibrium Green’s function (NEGF) formalism combined with the density functional theory (DFT) approach. Our results show that the adsorption of each amino acid on the HB nanodevice gives Fano resonance in the electronic transmission function. The sensitivity analysis and current–voltage (I–V) characteristic results indicate that selective detection of amino acids is possible. Thus, we believe that the HB-based device may be promising for the prospect of protein sequencing.

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Section: Introductionmentioning

confidence: 99%

Individual Identification of Amino Acids on an Atomically Thin Hydrogen Boride System Using Electronic Transport Calculations

Kumawat¹,

Jena²,

Pathak³

2020

J. Phys. Chem. C

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“…Some researchers and scientists have been trying for the last 2 decades not to use a biological machine for DNA sequencing. They instead want to perform DNA sequencing through solid-state nanoelectrodes by measuring electric read-outs, ionic currents ( I ), ,,, or tunneling current–voltage ( I – V ) characteristics. ,,− ,− It is observed that solid-state nanopore has several potential advantages such as robustness, size tunability, and compatibility with large-scale electronic chip production. , However, solid nanopores are yet to be realized practically to detect nucleobases individually. This bottleneck could be attributed to the higher thickness of the solid membranes to probe the local structure of DNA molecules, for example, silicon nitride (Si 3 N 4 ) membranes with a thickness of ∼10 nm, which is equivalent to ∼30 DNA nucleobases. , Consequently, researchers and scientists have switched toward thin membranes [such as graphene, ,,,− hexagonal boron nitride (h-BN), , and molybdenum disulfide (MoS 2 ) among others because of their atomic thickness, which may possibly yield distinct electric and ionic current responses from one or a few DNA nucleobases.…”

Section: Introductionmentioning

confidence: 99%

Identifying Single-Stranded DNA by Tuning the Graphene Nanogap Size: An Ionic Current Approach

Kumawat

Pathak

2022

J. Phys. Chem. B

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Solid nanopore-based deoxyribonucleic acid (DNA) sequencing has led to low-cost, fast, reliable, controlled, and amplified or label-free and high-resolution recognition and identification of DNA nucleotides. Solid-state materials and biological nanopores have a low signal-to-noise ratio (SNR) and generally are too thick to read at single-nucleotide resolution. The issue with solid-state nanopores is that the DNA strands stick to the nanopore sides and on the surface during the translocation process. The coexistence of DNA nucleotides on the surface and the nanopore sides will complicate the ionic current signals, making nucleotide detection difficult. Therefore, different sized nanogaps can be promising to overcome some of these issues. Using all-atom molecular dynamics (MD) simulations, we have studied the translocation of single-stranded (ss) DNA through solid-state nanogaps embedded in a graphene membrane device. A nucleotide-specific DNA sequencing technique is proposed based on unique differences in the ionic current responses for all the four ssDNA nucleotides (dAMP16, dGMP16, dTMP16, and dCMP16). As the individual homogeneous ssDNA translocate through the nanogaps, characteristic changes are observed in the ionic current. Our results show that ssDNA nucleotides can translocate through the proposed graphene nanogap devices by applying an external electric field. In addition, the sticking issue can be resolved using graphene nanogaps during the ssDNA translocation processes. Therefore, the significant difference in ionic current sensitivity and the translocation event/time yielded by the graphene nanogap-based devices reveal possibilities for utilizing it for ultrafast nanogap-based DNA sequencing.

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“…Considerable recent interest in the DNAgraphene hybrid structures [1][2][3][4][5] has been driven mainly by the applications of such structures in biosensors, in particular, medical diagnostics. Note also that graphene can be used as a carrier for DNA storage, hybridization, targeted assembling, and interaction of complementary chains [6].…”

Section: Introductionmentioning

confidence: 99%

Deposition and Visualization of DNA Molecules on Graphene That Is Obtained with the Aid of Mechanical Splitting on a Substrate with an Epoxy Sublayer

Frolov

Barinov

Klinov

et al. 2018

J. Commun. Technol. Electron.

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Sensing of DNA by graphene-on-silicon FET structures at DC and 101 GHz

Cited by 8 publications

References 16 publications

Individual Identification of Amino Acids on an Atomically Thin Hydrogen Boride System Using Electronic Transport Calculations

Individual Identification of Amino Acids on an Atomically Thin Hydrogen Boride System Using Electronic Transport Calculations

Identifying Single-Stranded DNA by Tuning the Graphene Nanogap Size: An Ionic Current Approach

Deposition and Visualization of DNA Molecules on Graphene That Is Obtained with the Aid of Mechanical Splitting on a Substrate with an Epoxy Sublayer

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