Sensing with ion current rectifying solid-state nanopores

Duleba, Dominik; Johnson, Robert P.

doi:10.1016/j.coelec.2022.100989

Cited by 21 publications

(21 citation statements)

References 44 publications

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Section: Introductionmentioning

confidence: 99%

“…Cervera et al , solved the Poisson–Nernst–Planck equations to demonstrate ICR theoretically. Numerous fundamental studies into the rectifying behavior of nanopores in aqueous electrolytes have been carried out, notably on the effect of variables including the electrolyte concentration and scan rate on the degree and direction of rectification. − Changes in ICR upon interaction with an analyte can be employed practically in sensing applications and are described by Duleba et al in a recent review paper. An interesting example, reported by Heaton and Platt, is a multiuse nanopore platform whose rectifying behavior is changed by placing a sheet of metal-immobilized paper on top of the nanopore .…”

Section: Introductionmentioning

confidence: 99%

“…While aqueous sensors are suitable for environmental − and biological applications, − they have limited use in industrial settings that feature aprotic solvent production processes, such as in pharmaceutical plants . A deeper understanding of the rectifying behavior of nanopores in non-aqueous electrolytes is essential in the development of ICR sensors compatible with organic solvents and will facilitate a wider range of applications than that for which such sensors are currently developed …”

Section: Introductionmentioning

confidence: 99%

“…23 A deeper understanding of the rectifying behavior of nanopores in non-aqueous electrolytes is essential in the development of ICR sensors compatible with organic solvents and will facilitate a wider range of applications than that for which such sensors are currently developed. 14 The ion current rectification of conical nanopores featuring an organic electrolyte is both less explored and more complex than for an aqueous electrolyte. Fundamental studies by Plett et al 24 and Yin et al 25 indicated a significant deviation in the rectifying behavior of nanopores in aprotic organic solvents compared to water, where the degree of ICR is dependent on the polarity of the solvent used.…”

Section: ■ Introductionmentioning

confidence: 99%

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Aprotic Solvent Accumulation Amplifies Ion Current Rectification in Conical Nanopores

2022

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Ion current rectification is highly reported in aqueous electrochemical systems and sensors but lacks exploration in organic systems due to the additional complexity introduced by non-aqueous solvents. Herein, a detailed study on ion current rectification with highly polar and mildly polar aprotic organic solvents as a function of tetraethylammonium tetrafluoroborate supporting electrolyte concentration is presented. To explain our experimental results, we introduce a previously unreported phenomenon: the formation of a double-junction diode within the nanopore that arises due to a complex interplay between ion and solvent enrichment effects. Finite element simulations are used to explore this phenomenon and the subsequent effect on the rectifying behavior of conical quartz nanopores.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aprotic Solvent Accumulation Amplifies Ion Current Rectification in Conical Nanopores

2022

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“…The patch‐clamp amplifier technique is based on resistive pulse sensing (RPS) in which the analyte is dynamically monitored by translocation of the pore, leading to transient pore blockage. The picoammeter is based on ion current rectification (ICR), which does not require extremely high temporal resolution [2] . Nanopore sensing technology is divided into two main areas: biological nanopores [3–7] and solid‐state nanopores [8–10] .…”

Section: Introductionmentioning

confidence: 99%

Solid‐state Nanopores: Chemical Modifications, Interactions, and Functionalities

Yang

et al. 2022

Chemistry An Asian Journal

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Nanopore technology is a burgeoning detection technology for single-molecular sensing and ion rectification. Solid-state nanopores have attracted more and more attention because of their higher stability and tunability than biological nanopores. However, solid-state nanopores still suffer the drawbacks of low signal-to-noise ratio and low resolution, which hinder their practical applications. Thus, developing operatical and useful methods to overcome the shortages of solid-state nanopores is urgently needed. Here, we summarize the recent research on nanopore modification to achieve this goal. Modifying solid-state nanopores with different coating molecules can improve the selectivity, sensitivity, and stability of nanopores. The modified molecules can introduce different functions into the nanopores, greatly expanding the applications of this novel detection technology. We hope that this review of nanopore modification will provide new ideas for this field.

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Solid‐State Glass Nanopipettes: Functionalization and Applications

Wang,

Tang,

Qiu

et al. 2024

Chemistry A European J

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Solid‐state glass nanopipettes provide a promising confined space that offers several advantages such as controllable size, simple preparation, low cost, good mechanical stability, and good thermal stability. These advantages make them an ideal choice for various applications such as biosensors, DNA sequencing, and drug delivery. In this review, we first delve into the functionalized nanopipettes for sensing various analytes and the methods used to develop detection means with them. Next, we provide an in‐depth overview of the advanced functionalization methodologies of nanopipettes based on diversified chemical kinetics. After that, we present the latest state‐of‐the‐art achievements and potential applications in detecting a wide range of targets, including ions, molecules, biological macromolecules, and single cells. We examine the various challenges that arise when working with these targets, as well as the innovative solutions developed to overcome them. The final section offers an in‐depth overview of the current development status, newest trends, and application prospects of sensors. Overall, this review provides a comprehensive and detailed analysis of the current state‐of‐the‐art functionalized nanopipette perception sensing and development of detection means and offers valuable insights into the prospects for this exciting field.

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Sensing with ion current rectifying solid-state nanopores

Cited by 21 publications

References 44 publications

Aprotic Solvent Accumulation Amplifies Ion Current Rectification in Conical Nanopores

Aprotic Solvent Accumulation Amplifies Ion Current Rectification in Conical Nanopores

Solid‐state Nanopores: Chemical Modifications, Interactions, and Functionalities

Solid‐State Glass Nanopipettes: Functionalization and Applications

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