Sensitisation of preruminant calves and piglets to antigenic protein in early weaning diets: control of the systemic antibody responses

Heppell, L. M. J.; Sissons, J. W.; Banks, Steve

doi:10.1016/s0034-5288(18)31216-5

Cited by 20 publications

(9 citation statements)

References 14 publications

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“…However, the role of circulating soybean antigens in this unresponsiveness cannot be ruled out. In contrast, when feeding calves with soybean proteins Heppell et al (1989) found that oral sensitisation followed by parenteral sensitisation resulted in significantly higher anti-soy titres than oral sensitisation alone. This suggests that, in contrast to piglets, calves fail to develop oral tolerance.…”

Section: Immunity and Tolerancementioning

confidence: 78%

Soybean: feed quality and safety. Part 2: Pathology of soybean feeding in animals. A review

Csáky

Fekete

2004

Acta Veterinaria Hungarica

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Various animal models in farm and laboratory animals indicate the possible pathological effect of soybean feeding. Immunity and tolerance to oral soybean intake and a generalised meta-model of effects are discussed. It seems that FAO/WHO recommendations will have to be considered in assessing the biological value of soybean feed sources. Determination of hull content, antigenic potential, conglycinin and trypsin inhibitor content is warranted in view of the future component pricing of soybean meals.Key words: Soybean, villus height, antibody to soybean antigens, feed antigens, immune tolerance to feed, soybean pathology model, soybean allergy, component pricingIntestinal pathology in soybean fed animals McGuinnes et al. (1987) observed that rats fed on raw soybean meal developed enlarged pancreas and hyperplastic nodules which turned to adenomas and carcinoma. The effect was attributed to trypsin inhibitor effect, due to increased cholecystokinin plasma levels. According to Grant et al. (1987) the effect of pure soybean trypsin inhibitor on pancreas hypertrophy was less pronounced when it was fed in the form of soybean meal.Mice fed on raw soybeans survive only for weeks (Gee and Morgan, 1993). Feeding raw soybeans increases duodenal mucosa and smooth muscle layer thickness, but heat treatment significantly reduces this effect. Small intestinal weight is significantly increased in mice fed raw soybean meal (2.242 g vs. 1.410 g). A similar difference was observed in pancreas weight (0.547 g vs. 0.251 g). A similar effect was noted upon the administration of camostate (synthetic trypsin inhibitor), suggesting the role of trypsin inhibitors in the pancreas effect. However, small intestinal weight and structure are not influenced by camostate (unlike raw soybean meal), which suggests disparate effects on small intestine and pancreas. Pusztai et

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Section: Immunity and Tolerancementioning

confidence: 78%

Soybean: feed quality and safety. Part 2: Pathology of soybean feeding in animals. A review

Csáky

Fekete

2004

Acta Veterinaria Hungarica

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“…The phenomenon of antigen-specific, systemic immu nological tolerance induced by prior feeding of the anti gen (so-called 'oral tolerance') has been described in sev eral species [1,2] including the pig [3,4], and it has been suggested as a regulatory mechanism in preventing da maging immunological responses to proteins absorbed across the mucosa. In these systems, immunological toler ance has generally been assessed by systemic rather than oral antigenic challenge, since in rodents active primary immune responses to novel, fed proteins have been diffi cult to demonstrate [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Altered Immune Response to Proteins Fed after Neonatal Exposure of Piglets to the Antigen

Bailey

Miller²,

Telemo³

et al. 1994

Int Arch Allergy Immunol

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The weaning of piglets onto soya proteins at 3 weeks old normally results in an active response to the fed protein, as determined by the appearance of serum IgG antisoya antibody. This system thus allows the effects of manipulation on the response to a fed protein to be studied. In animals previously given 1 g of soya protein at birth, the magnitude of the antibody response to soya fed at 3 weeks was decreased, although similar amounts of the fed protein could be detected in serum. In addition, the relative affinity of the dominant interaction between antigen and antibody was reduced in these piglets by almost an order of magnitude. By comparison, the ability of piglets given soya at birth to respond to injected soya was not significantly reduced. These results indicate that the regulation of responses to fed and systemic antigens is largely separate. Very early oral exposure to antigen may affect the ability of neonatal animals to mount immune responses to, specifically, fed proteins while leaving the response to systemic antigen largely intact.

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“…Although underlying mechanisms are not fully understood, mature ruminants do not seem to be affected by gut hypersensitivity to dietary antigens. It has been speculated (Barratt et al 1978; Kilshaw, 1981;Stokes, 1984;Heppell et al 1989) that rumen degradation rather than specific immune factors plays a major role in inactivating potential allergens. Indeed, in vitro fermentation of various soybean products has successfully reduced their antigenicity (Barratt et al 1978;Srihara et al 1982;Mir et al 1989) and allowed improvements in calf performance when used in milk replacers (Mir et al 1991).…”

mentioning

confidence: 99%

Digestion of soybean globulins, glycinin, α-conglycinin and β-conglycinin in the preruminant and the ruminant calf

Tukur¹,

Lallès²,

Mathis³

et al. 1993

Can. J. Anim. Sci.

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Sensitisation of preruminant calves and piglets to antigenic protein in early weaning diets: control of the systemic antibody responses

Cited by 20 publications

References 14 publications

Soybean: feed quality and safety. Part 2: Pathology of soybean feeding in animals. A review

Soybean: feed quality and safety. Part 2: Pathology of soybean feeding in animals. A review

Altered Immune Response to Proteins Fed after Neonatal Exposure of Piglets to the Antigen

Digestion of soybean globulins, glycinin, α-conglycinin and β-conglycinin in the preruminant and the ruminant calf

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