Sensitisation to fungi in atopic dermatitis patients over 14 years of age and the relation to the occurrence of food hypersensitivity reactions

Abstract

The aim of this study was to evaluate if there is some relation between the sensitisation to fungi and the occurrence of food hypersensitivity reactions in atopic dermatitis patients aged 14 years and older. Complete dermatological and allergological examination was performed in all included patients; the occurrence of food hypersensitivity reactions was recorded and the sensitisation to mixture of fungi was examined (skin prick test, specific IgE). The statistical evaluation of the relation between the sensitisation to fungi and the occurrence of food hypersensitivity reactions was performed; 331 patients were included in the study, 110 men and 221 women, the average age was 26.8 years. The sensitisation to fungi was recorded in 100 patients (30%), the occurrence of food hypersensitivity reactions was recorded in 261 patients (79%). We confirmed that patients suffering from sensitisation to fungi suffer significantly more often from food hypersensitivity reactions to nuts (walnuts, peanuts) and sea fish; no significant relation was confirmed between the sensitisation to fungi and the occurrence of food hypersensitivity reactions to tomatoes, kiwi, apples, spices, oranges, capsicum, celery and carrot.

Sensitisation to molecular allergens of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus in atopic dermatitis patients

“…In our previous studies we confirmed, that sensitisation to fungi (according to the examination with extract sIgE and skin prick test) was recorded in 30% patients suffering from atopic dermatitis Čelakovská, Bukač, Ettler, Vaneckova, Krcmova, et al, 2018).…”

“…In our previous publications, we demonstrated our results regarding the sensitisation to fungi in atopic dermatitis patients with the examination of skin prick test and specific IgE (Čelakovská, Bukač, Ettler, Vaneckova, Krcmova, et al, 2018;.…”

Sensitization to fungi in atopic dermatitis patients 14 year and older – Association with other atopic diseases and parameters

“…[43] In our previous study we confirmed that patients suffering from sensitization to fungi suffered significantly more from food hypersensitivity reactions to nuts and fishes. [44] The antifungal effect of plant proteins (defensins and lipid transfer proteins) probably cannot be applied, as also the antifungal effect of fatty acids methyl esters in fish. [44] In India, Bains and Dogra determined the prevalence of positive SPT in patients with chronic allergic skin disorders.…”

“…[44] The antifungal effect of plant proteins (defensins and lipid transfer proteins) probably cannot be applied, as also the antifungal effect of fatty acids methyl esters in fish. [44] In India, Bains and Dogra determined the prevalence of positive SPT in patients with chronic allergic skin disorders. [45] Fifty patients with chronic allergic disorders were recruited in this study.…”

Sensitisation to outdoor and indoor fungi in atopic dermatitis patients and the relation to the occurrence of food allergy to peanuts and walnuts

“…We found no relation between the sensitisation to fungi and the occurrence of food hypersensitivity reactions to other foods (tomatoes, kiwi, apples, spices, oranges, capsicum, celery, carrots and strawberries). 16 Among the over 100 000 fungal species reported, only a few hundred have been described as opportunistic pathogens causing human illness through 3 specific mechanisms: direct infection of the host, elicitation of deregulated immune responses and toxic effects due to secondary metabolites. 17-20…”