Sensitisation to molecular components in patients with atopic dermatitis, relation to asthma bronchiale and allergic rhinitis

Čelakovská, Jarmila; Bukač, Josef; Vaňková, R.; Krčmová, Irena; Krejsek, Jan; Andrýs, Ctirad

doi:10.1080/09540105.2020.1747406

Cited by 8 publications

(4 citation statements)

References 49 publications

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“…Dehydrated and thinner skin of AD patients is much more vulnerable to injury and therefore to infection and irritation by allergens [ 26 ]. Celakovska and Bukac [ 27 , 28 ] observed the significant relation between the severity of AD and sensitization mites, animal dander, dust of feather. According to authors observation patients with strong or moderate form of AD suffer more often from sensitization to aboved factors.…”

Section: Disscussionmentioning

confidence: 99%

Determination of nasal carriage and skin colonization, antimicrobial susceptibility and genetic relatedness of Staphylococcus aureus isolated from patients with atopic dermatitis in Szczecin, Poland

2021

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Background Atopic dermatitis (AD) is one of the most frequent chronic and inflammatory skin condition. AD is characterized by damaged epidermal barrier, xerosis and pruritus of eczematous skin lesions which tend to flare. The duration and frequency of exacerbation of AD symptoms markedly affects the quality of patient life. AD results from the interplay between host genetics, immunity, and environmental factors, however the detailed pathogenesis of this disease is still not entirely cleared. Furthermore, disturbances of the skin microbiota and skin functional impairment predispose to secondary skin infections. Staphylococcus aureus colonizes skin and mucous membranes of 20 to 80% of healthy individuals and of 90% of patients with AD in whom this bacterium is accounted as an important AD exacerbating factor. It is also proven, that S. aureus nasal carriage significantly increases the risk for self-transmission and endogenous infection. In the current study the presence of S. aureus either in nasal vestibule and on lesioned skin of 64 patients with AD enrolled in 10-year autovaccination program was determined. The genetic relatedness of 86 S. aureus isolated from patients nose and skin using Pulsed Field Gel Electrophoresis (PFGE) and antimicrobial susceptibility of all strains to methicillin, erythromycin, clindamycin, mupirocin, gentamicin, amikacin, tetracycline, chloramphenicol and cotrimoxazole was also evaluated. Results In total 23 PFGE genotypes and 24 unique patterns were distinguished. 34 patients were S. aureus nasal carriers. Simultaneous presence of S. aureus in nose and on affected skin was found in 16 carriers colonized by indistinguishable or potentially related S. aureus vs 2 carriers colonized with non-related S. aureus in nasal vestibule and on skin. 4 isolates were methicillin resistant (MRSA) among which 3 showed constitutive MLSB resistance phenotype and remaining one was resistant to tetracycline and chloramphenicol. In 4 isolates inducible MLSB resistance phenotype was found, one of them was additionally resistant to tetracycline. 7 S. aureus were mupirocin resistant among them 3 - isolated from one patient, were resistant simultaneously to tetracyclines and chloramphenicol. 7 strains demonstrated resistance to chloramphenicol and susceptibility to all tested antimicrobial agents. The susceptibility to gentamicin, amikacin and cotrimoxazole among all examined S. aureus was confirmed. Conclusion The obtained results indicated non-clonal structure of S. aureus circulating in AD patients. PFGE results showed the clonal-structure of vast majority of S. aureus isolated from nose and skin from nasal carriers what may prove the autoinfection in these patients. All examined patients the moderate or strong severity of AD was reported. Susceptibility to most antibiotics among isolated strains was also observed.

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Section: Disscussionmentioning

confidence: 99%

Determination of nasal carriage and skin colonization, antimicrobial susceptibility and genetic relatedness of Staphylococcus aureus isolated from patients with atopic dermatitis in Szczecin, Poland

2021

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“…Last but not least, as we know, atopic march refers to the progress of atopic dermatitis in infancy and subsequent allergic rhinitis and asthma in later childhood ( 36 ). In terms of allergens, multiple molecular components from animals and fungi have also been found to be simultaneously elevated in patients suffering from severe form of atopic dermatitis, asthma and allergic rhinitis ( 37 , 38 ). Therefore, the co-existence of two or even three allergic diseases is not uncommon, and a cohort study of up to 6 million Korean subjects presented evidence that patients with multiple atopic conditions have a higher risk for AF than one alone ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Association of atopic diseases with atrial fibrillation risk: A systematic review and meta-analysis

Zeng

Wang²,

Liang³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundAtopic diseases and atrial fibrillation (AF) seem to share an underlying inflammatory pathology. To date, some population-based studies have explored the relationship between the two. We aimed to conduct a meta-analysis to examine the role of atopic condition in AF risk.MethodsAll relevant observational studies in PubMed and EMBASE databases up to November 2021 were searched. In RevMan 5.3, we used random-effects or fixed-effects models to pool the effect sizes of hazard ratio (HR), odds ratio (OR) and their corresponding 95% confidence intervals (95% CI). In addition, I2 and Cochran Q test were used to evaluate the heterogeneity.ResultsA total of 2488 records were retrieved. After screening according to the predetermined criteria, 6 cohort studies and 2 case-control studies were included in this meta-analysis. Herein, the meta-analysis of 6 cohort studies suggested that atopic diseases potentially increased the AF risk with the pooled HR of 1.26 (95%CI,1.14–1.39), while the pooled effect size (OR, 1.04; 95%CI,0.74–1.46) of 2 case-control studies was not statistically significant. Based on the types of atopic diseases, further subgroup analyses of 6 cohort studies revealed that asthma, allergic rhinitis, and atopic dermatitis all potentially increased the risk of subsequent AF with the pooled HR of 1.41 (n = 4; 95%CI, 1.25–1.58), 1.12 (n = 1; 95%CI,1.10–1.14) and 1.06 (n = 3; 95%CI, 1.01–1.12), respectively.ConclusionThis meta-analysis demonstrated that patients with atopic diseases have a higher risk of developing AF, particularly those with asthma.

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“…When it comes to allergen immunotherapy, perspectives on accurate diagnoses and tactics include less expensive treatments with greater effectiveness and shorter treatment periods, but earlier diagnosis as well. The treatment of allergic diseases with ASIT begins in childhood, including the treatment of atopic dermatitis in children possibly tested for its ability to avoid allergic comorbidity patterns [107] .…”

Section: Future Perspectivementioning

confidence: 99%

Novel approaches for allergen-specific immunotherapy—An overview

Sakshi,

Mazumder,

Monika

et al. 2023

Trends Immunother

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Allergen-specific immunotherapy (AIT) is an allergen-specific treatment for people with IgE-related allergies. Allergen-specific immunotherapy (AIT) is used to treat allergic disorders when symptoms persist despite medication and allergen avoidance. The therapy is presumed effective if it reduces the use of medications, improves the quality of life even after discontinuation of treatment, as well as prevents the conversion of one type of allergy to the other and the development of new sensitization. The allergen-specific immunotherapeutic agents can be administered sublingually, subcutaneously, or through some other routes, such as intra-lymphatically and epicutaneously to induce allergen tolerance by modifying immune responses (innate and adaptive). The primary mechanism of AIT is the induction of functional regulatory cells, such as regulatory T cells, follicular T cells, B cells, dendritic cells, innate lymphoid cells, and natural killer cells, which results in the control of the functions of type 2 inflammatory cells. However, there are several downsides to AIT, including the contentious treatment period resulting in high cost, systemic allergic reactions, and the lack of a biomarker for forecasting treatment responders. Vaccine adjuvants, adjunctive therapies, and novel vaccine technologies are currently being researched to address the issues associated with AIT. This article focuses on defined molecular approaches for improving the potential of specific immunotherapy that use recombinant allergen derivatives, allergen-derived peptides, virus-coupled allergens, nanoparticles, and specific adjuvants.

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Sensitisation to molecular components in patients with atopic dermatitis, relation to asthma bronchiale and allergic rhinitis

Cited by 8 publications

References 49 publications

Determination of nasal carriage and skin colonization, antimicrobial susceptibility and genetic relatedness of Staphylococcus aureus isolated from patients with atopic dermatitis in Szczecin, Poland

Determination of nasal carriage and skin colonization, antimicrobial susceptibility and genetic relatedness of Staphylococcus aureus isolated from patients with atopic dermatitis in Szczecin, Poland

Association of atopic diseases with atrial fibrillation risk: A systematic review and meta-analysis

Novel approaches for allergen-specific immunotherapy—An overview

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