Sensitive and non-invasive assessment of hepatocellular iron using a novel room-temperature susceptometer

Mueller, Johannes; Raisi, H; Rausch, Vanessa; Peccerella, Teresa; Simons, David; Ziener, Christian H.; Schlemmer, Heinz Peter; Seitz, Helmut K.; Waldburger, Nina; Longerich, Thomas; Straub, Beate K.; Mueller, Sebastian

doi:10.1016/j.jhep.2017.04.019

Cited by 14 publications

(20 citation statements)

References 37 publications

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“…Magnetic susceptometry is an emerging non‐invasive mechanism by which to assess hepatic iron concentration, and preliminary studies with a room temperature susceptometer have demonstrated a highly linear correlation ( r 2 = 0.998) between its signal and hepatic iron concentration . The performance parameters of the susceptometer for detection of hepatic iron overload (grade ≥2) have been equal to those of atomic absorption spectroscopy and superior to all serum iron markers.…”

Section: Resultsmentioning

confidence: 99%

“…The performance parameters of the susceptometer for detection of hepatic iron overload (grade ≥2) have been equal to those of atomic absorption spectroscopy and superior to all serum iron markers. Furthermore, iron removal by phlebotomy could be accurately monitored …”

Section: Resultsmentioning

confidence: 99%

“…Magnetic susceptibility measures the attraction or repulsion of a given material by a magnetic field, and it originally required a highly complex and expensive device based on superconductor technology and liquid helium for cooling. Magnetic susceptibility can now be determined at the bedside by a helium‐free, room temperature susceptometer that could be cost‐effective compared to MRI . Room temperature susceptometry at the bedside has the potential to facilitate future investigations of the pathogenic role of iron overload and its removal in the chronic liver diseases that are not hereditary haemochromatosis.…”

Section: Resultsmentioning

confidence: 99%

“…Future investigations must continue to understand the pathogenic association between the iron overload and liver disease and develop confident, measurable thresholds of hepatic iron toxicity that compel intervention. Studies based on hepatic iron content must refine correlations with surrogate markers of iron overload to eliminate overestimations of risk, and cost‐effective non‐invasive evaluations of hepatic iron content, such as the room temperature susceptometer, must continue to be developed and applied.…”

Section: Resultsmentioning

confidence: 99%

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Review article: iron disturbances in chronic liver diseases other than haemochromatosis – pathogenic, prognostic, and therapeutic implications

Czaja

2019

Aliment Pharmacol Ther

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Background: Disturbances in iron regulation have been described in diverse chronic liver diseases other than hereditary haemochromatosis, and iron toxicity may worsen liver injury and outcome. Aims:To describe manifestations and consequences of iron dysregulation in chronic liver diseases apart from hereditary haemochromatosis and to encourage investigations that clarify pathogenic mechanisms, define risk thresholds for iron toxicity, and direct management Methods: English abstracts were identified in PubMed by multiple search terms.Full length articles were selected for review, and secondary and tertiary bibliographies were developed.Results: Hyperferritinemia is present in 4%-65% of patients with non-alcoholic fatty liver disease, autoimmune hepatitis, chronic viral hepatitis, or alcoholic liver disease, and hepatic iron content is increased in 11%-52%. Heterozygosity for the C282Y mutation is present in 17%-48%, but this has not uniformly distinguished patients with adverse outcomes. An inappropriately low serum hepcidin level has characterised most chronic liver diseases with the exception of non-alcoholic fatty liver disease, and the finding has been associated mainly with suppression of transcriptional activity of the hepcidin gene. Iron overload has been associated with oxidative stress, advanced fibrosis and decreased survival, and promising therapies beyond phlebotomy and oral iron chelation have included hepcidin agonists. Conclusions:Iron dysregulation is common in chronic liver diseases other than hereditary haemochromatosis, and has been associated with liver toxicity and poor prognosis. Further evaluation of iron overload as a co-morbid factor should identify the key pathogenic disturbances, establish the risk threshold for iron toxicity, and promote molecular interventions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Review article: iron disturbances in chronic liver diseases other than haemochromatosis – pathogenic, prognostic, and therapeutic implications

Czaja

2019

Aliment Pharmacol Ther

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“…We read with interest the study by Mueller et al describing the use of room temperature susceptometer (RTS) to assess hepatic iron content (HIC). 1 This is an interesting clinical application of the methods described by Avrin et al 2,3 This topic is relevant as there is still a need for a cost-effective and efficient iron quantification method in liver disease.…”

Section: To the Editormentioning

confidence: 99%

Is room temperature susceptometer really an accurate method to assess hepatocellular iron?

Pathil

Lainé

Gandon

et al. 2017

Journal of Hepatology

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Serum or plasma ferritin concentration as an index of iron deficiency and overload

Garcı́a-Casal

Pasricha

Martinez

et al. 2021

Cochrane Database of Systematic Reviews

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Sensitive and non-invasive assessment of hepatocellular iron using a novel room-temperature susceptometer

Cited by 14 publications

References 37 publications

Review article: iron disturbances in chronic liver diseases other than haemochromatosis – pathogenic, prognostic, and therapeutic implications

Review article: iron disturbances in chronic liver diseases other than haemochromatosis – pathogenic, prognostic, and therapeutic implications

Is room temperature susceptometer really an accurate method to assess hepatocellular iron?

Serum or plasma ferritin concentration as an index of iron deficiency and overload

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